Estonian Biobank
@ESTbiobank
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DNA samples and extensive health records of 20% of the adult population of Estonia (212,000 individuals), applied in 100s of international research projects.
Estonia
Joined April 2017
🚨 New preprint out! We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation. This reveals intensified assortment in recent generations. 🔗 https://t.co/wnag6TiWWo
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Great news! Our Associate Professor of Neuropsychiatric Genomics, Kelli Lehto, has been selected to receive the European Research Council grant! 💐Congrats on that outstanding achievement! 👉 https://t.co/oVmN9UgXvn
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A study of genetic effects on adverse events from antidepressants in the Estonian Biobank: CYP2C19 and polygenic risk scores. @ESTbiobank @MilaniLili @HannaKariis
https://t.co/L2yawUEZPO
nature.com
European Journal of Human Genetics - Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank
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🚨 Our parent-of-origin study is out in @Nature ! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 https://t.co/OWW6vGxGYI Highlights below!
nature.com
Nature - A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
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🎉 Excited to share that our latest paper is now published! We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @ESTbiobank, leveraging data from questionnaires and clinical notes using NLP. https://t.co/Easbg4XDet
nature.com
European Journal of Human Genetics - Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank
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A study in @NatureMedicine provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. https://t.co/Kd3Fu1fYXd 🔒
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Excited to share our recently published overview of the @ESTbiobank 🧬 We highlight the unique features of the biobank and the conducted scientific research, including the many recall studies that have been carried out over the years: https://t.co/q7k7f2CuS8
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💡Can we use real world drug purchase data to study the genetics of medication dosing? We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵 📄
medrxiv.org
Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing drug response, the polygenic contribution to dose variability and the potential of electronic health...
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Tremendous work by @PujolGualdo @TLaisk and team! 👏🏼👏🏼👏🏼
A new study provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. @genomicstartu #ReproductiveHealth
https://t.co/JoenfG1rim
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New paper out: microbiome and causal inference! Let us tell you a bit more:
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🧬🧠Recent research @ESTbiobank @genomicstartu revealed that high genetic liability to #ADHD raises risks for 80 health conditions like #COPD (+70%), #obesity (+60%) & type 2 diabetes #T2D (+45%) - even without an ADHD diagnosis. Better screening & awareness for adults is needed!
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1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @CellCellPress. https://t.co/5ZtpbzKLpx A thread 🧵:
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Delighted to accompany President Dr. @MMuizzu on his visit to the @unitartu Institute of Molecular and Cell Biology, today. We were warmly welcomed by Professor @MilaniLili, Head of Estonian Biobank & Professor of Pharmacogenomics and had an inspiring exchange on advancing
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We are delighted to contribute with Estonian Biobank data to this massive collaboration 🎉 So glad to see this work published!
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @CellCellPress. https://t.co/5ZtpbzKLpx A thread 🧵:
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This is what happens when you return research results to biobank participants: ✅The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?” ✅"Estonian Biobank" among Top10 search terms. Huge thanks to all at @ESTbiobank & @genomicstartu ✨
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🦠 Excited to share our new collection of human gut #archaea species! 🎉 🇪🇪From @ESTbiobank, we present a dataset of 144 strains across 21 species, including 9 entirely new species! A thread 🧵 #MAG #EstMB #TartuMicrobiome #microbiome #humangut
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In @Laboratorynews, I discuss the role of biobanks in revolutionising precision medicine. 🧬 I explain how the @ESTbiobank is using genomic insights to better understand the factors influencing public health and disease. Read more, here 👉 https://t.co/Ct24EkYsLI #Biobanks
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🚨 Our preprint on parent-of-origin effects (POEs) is out! With our new method, we inferred the parental origin of >220,000 individuals, revealing new insights into the genetic architecture of complex traits. 👉 Read here: https://t.co/dm4limMAqM 👇 Highlights below!
medrxiv.org
Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from...
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1/6 🚨 Thrilled to share our new preprint on the genetics of dermatophytosis susceptibility on @medrxivpreprint! 🚨 With over 250K cases and 1.37M controls across 4 cohorts, we uncover 30 loci that affect risk for this fungal infection affecting 20% of the global population. 🌍
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Happy to share our most recent GWAS meta-analysis of 249 circulating metabolic biomarkers (@NgaleHealth platform) in up to 619,372 individuals. https://t.co/61Vid5RO5m
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