Hiran A. Prag
@hiranprag
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Group Leader and Lecturer at University of Manchester | Pharmacist | F1 fanatic | Stupid views will be my own.
Cambridge, England
Joined January 2019
Extremely pleased to share our latest work (@thomaskrieglab and @Mito_Redox) on the ischemia-selective protection against cardiac ischemia/reperfusion (IR) injury by malonate, out now in @CircRes. https://t.co/2KMT2ffUCg (open access - so freely available!) 1/7
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Explore novel therapeutic opportunities in #stroke this #WorldStrokeDay Local arterial administration of acidified malonate as an adjunct therapy to thrombectomy may attenuate ischaemia–reperfusion injury &⬇️brain damage up to 60% https://t.co/4XWer38pUh
#CardiovascularResearch
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I have three exciting, interdisciplinary mitochondria-focused PhD projects open as part of the MRC DTP or Bicentenary studentship programmes at the University of Manchester. For more information, see:
findaphd.com
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Glad to have played a small part in this! Congratulations @dunjaaks!
🚨T2D in 🚺 worsens STEMI outcomes beyond door-to-balloon delays & mirrors the HFpEF cardiometabolic phenotype in female db/db mice. Sex-specific strategies are urgently needed! Congrats to study co-leads @1blueivy @megan_e_young @BioMedCentral @QMULWHRI
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🚨 New paper out from us, reveals a novel role for mitochondrial RET-ROS in #HFpEF. 🧬 ND6 mutation ➡️ 🫀 Hypertrophy 💔 Diastolic dysfunction 🏃♂️ ↓ Exercise capacity 💪 ↑ Lean mass 🍩 HFD worsened metabolism ✅ Exercise reversed many effects! https://t.co/bBGBQR8NoA
journals.physiology.org
Central to the development of heart failure with preserved ejection fraction (HFpEF) is the redox disruption of metabolic processes; however, the underlying mechanisms are not fully understood. This...
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I’m excited to share the first paper from my lab, out today in @ScienceAdvances! https://t.co/MlZTyA6OOQ We uncover a new family of phospholipid remodelling enzymes. A 🧵:
science.org
TRAM–LAG1–CLN8 family proteins function as enzymes that remodel cellular phospholipids and expand the membrane lipid diversity.
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Have a look at our new story demonstrating chronic benefits against heart failure when malonate is given at reperfusion. @Mito_Redox @hiranprag @AnaVujic5
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Delighted to share the last study of the lab led by the fantastic postdoc @Tabara_LC out in @CellCellPress !!! We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. @MRC_MBU @Cambridge_Uni
https://t.co/xM0vjtReOW
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We have a funded Phd position available in the lab in collaboration with @mito_gene !! A project that combines mitochondrial dynamics analysis, mtDNA editing and microscopy! Have a look and apply if interested @MRC_MBU @Cambridge_Uni
PhD studentship for entry in October 2024. @LabPrudent & @mito_gene Closes 16 May. Applications welcome from UK and International students Project title below. For further details and how to apply see: https://t.co/qPhEtjmu4d
https://t.co/54iI8UNgY8
https://t.co/QdBrhM7ye5
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Our @NatureComms study out today identified unique🫀 #metabolism and 🧬adaptations in #nakedmolerats enabling #ATP provision and minimal tissue damage post #ischemia @moleratsarego @QM_SBBS @Mito_Redox @kingscardio @UPTuks @Cambridge_Uni
https://t.co/4xKxnWX8Do
nature.com
Nature Communications - The naked mole-rat exhibits extreme longevity, resistance to hypoxia and absence of cardiovascular disease. Here, Faulkes et al. identify mechanisms behind these traits by...
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Review just out in Nature from Luke O'Neill and me https://t.co/jgmMwV7kJL
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Exciting PhD opportunity with my close collaborator Richard Hartley on Mitochondrial Chemical Biology https://t.co/xsTgbDw5Om
findaphd.com
PhD Project - PhD in Chemistry - Molecular probes to explore the role of methionine in redox signalling at University of Glasgow, listed on FindAPhD.com
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Job Alert! Our team is recruiting one Postdoctoral fellow and one PhD student! @MRC_MBU @Cambridge_Uni Both projects are linked to mitochondrial membrane remodelling and mtDNA dynamics!! Postdoc: https://t.co/YrwAkpuzoR PhD student (with @mito_gene) :
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Have a look at our recent review highlighting RET as a potential treatment against IR injury. @hiranprag @Mito_Redox
link.springer.com
Basic Research in Cardiology - In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a crucial trigger for...
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Continuing #cardiacmetabolism theme @ISHR_ES @ISHR2023 “Targeting metabolic pathways towards treatment of cardiac diseases” with @hiranprag @gabrieleschiat1 Frank Lezoualch @Mito_Redox Beautiful cutting edge science!
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Fantastic opportunity to work with @AnaVujic5 at @Cambridge_Uni. Ana is doing some really exciting research and would highly recommend. I've been lucky enough to work with Ana and she is a great mentor!
Exciting news! I am recruiting, and looking for a talented Research Assistant. If you're passionate about heart failure and want to be part of an innovative and dynamic research team, I want to hear from you! Link: https://t.co/HnodOYUzgB
@Cambridge_Uni, @Cambridgecardio
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Happy to share our latest work where we show that CISD1/Cisd accumulates in pink1-parkin mutant flies and has an important role in age-related neurodegeneration. Thank you @whitworth_lab @alsanchezmar @MRC_MBU and all the rest of the co-authors! https://t.co/KpD07YWCnU
biorxiv.org
Background Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Functional...
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Pleased to be a small part of a paper just out - led by Amanda Bungaard and Angela Fago - on how turtle hearts avoid ischaemia-reperfusion injury. Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts
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Congrats to Shinpei whose paper is now out. https://t.co/IP1SYfYjgQ
chemistry-europe.onlinelibrary.wiley.com
Triphenylphosphonium (TPP) cation is widely used for selective delivery of compounds into mitochondria. This study demonstrated that the replacement of an alkyl chain with polyethylene glycol (PEG)...
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Fantastic news @AnaVujic5, cannot wait to see the research coming out of the Vujic lab
Huge congratulations to Ana @AnaVujic5 on receiving the prestigious @TheBHF Intermediate Research Fellowship and becoming a PI! Thrilled and very proud of this. @Mito_Redox @Cambridgecardio @MedCambridge @TVPLab
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