Hiran A. Prag
@hiranprag
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Postdoc tackling ischemia/reperfusion injury @thomaskrieglab and @Mito_Redox | @TheBHF funded | Pharmacist | F1 fanatic | Stupid views will be my own.
Cambridge, England
Joined January 2019
Extremely pleased to share our latest work (@thomaskrieglab and @Mito_Redox) on the ischemia-selective protection against cardiac ischemia/reperfusion (IR) injury by malonate, out now in @CircRes. https://t.co/2KMT2ffUCg (open access - so freely available!) 1/7
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Glad to have played a small part in this! Congratulations @dunjaaks!
🚨T2D in 🚺 worsens STEMI outcomes beyond door-to-balloon delays & mirrors the HFpEF cardiometabolic phenotype in female db/db mice. Sex-specific strategies are urgently needed! Congrats to study co-leads @1blueivy @megan_e_young @BioMedCentral @QMULWHRI
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🚨 New paper out from us, reveals a novel role for mitochondrial RET-ROS in #HFpEF. 🧬 ND6 mutation ➡️ 🫀 Hypertrophy 💔 Diastolic dysfunction 🏃♂️ ↓ Exercise capacity 💪 ↑ Lean mass 🍩 HFD worsened metabolism ✅ Exercise reversed many effects! https://t.co/bBGBQR8NoA
journals.physiology.org
Central to the development of heart failure with preserved ejection fraction (HFpEF) is the redox disruption of metabolic processes; however, the underlying mechanisms are not fully understood. This...
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I’m excited to share the first paper from my lab, out today in @ScienceAdvances! https://t.co/MlZTyA6OOQ We uncover a new family of phospholipid remodelling enzymes. A 🧵:
science.org
TRAM–LAG1–CLN8 family proteins function as enzymes that remodel cellular phospholipids and expand the membrane lipid diversity.
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Have a look at our new story demonstrating chronic benefits against heart failure when malonate is given at reperfusion. @Mito_Redox @hiranprag @AnaVujic5
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Delighted to share the last study of the lab led by the fantastic postdoc @Tabara_LC out in @CellCellPress !!! We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. @MRC_MBU @Cambridge_Uni
https://t.co/xM0vjtReOW
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We have a funded Phd position available in the lab in collaboration with @mito_gene !! A project that combines mitochondrial dynamics analysis, mtDNA editing and microscopy! Have a look and apply if interested @MRC_MBU @Cambridge_Uni
PhD studentship for entry in October 2024. @LabPrudent & @mito_gene Closes 16 May. Applications welcome from UK and International students Project title below. For further details and how to apply see: https://t.co/qPhEtjmu4d
https://t.co/54iI8UNgY8
https://t.co/QdBrhM7ye5
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Our @NatureComms study out today identified unique🫀 #metabolism and 🧬adaptations in #nakedmolerats enabling #ATP provision and minimal tissue damage post #ischemia @moleratsarego @QM_SBBS @Mito_Redox @kingscardio @UPTuks @Cambridge_Uni
https://t.co/4xKxnWX8Do
nature.com
Nature Communications - The naked mole-rat exhibits extreme longevity, resistance to hypoxia and absence of cardiovascular disease. Here, Faulkes et al. identify mechanisms behind these traits by...
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Review just out in Nature from Luke O'Neill and me https://t.co/jgmMwV7kJL
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Exciting PhD opportunity with my close collaborator Richard Hartley on Mitochondrial Chemical Biology https://t.co/xsTgbDw5Om
findaphd.com
PhD Project - PhD in Chemistry - Molecular probes to explore the role of methionine in redox signalling at University of Glasgow, listed on FindAPhD.com
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Job Alert! Our team is recruiting one Postdoctoral fellow and one PhD student! @MRC_MBU @Cambridge_Uni Both projects are linked to mitochondrial membrane remodelling and mtDNA dynamics!! Postdoc: https://t.co/YrwAkpuzoR PhD student (with @mito_gene) :
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Have a look at our recent review highlighting RET as a potential treatment against IR injury. @hiranprag @Mito_Redox
link.springer.com
Basic Research in Cardiology - In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a crucial trigger for...
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Continuing #cardiacmetabolism theme @ISHR_ES @ISHR2023 “Targeting metabolic pathways towards treatment of cardiac diseases” with @hiranprag @gabrieleschiat1 Frank Lezoualch @Mito_Redox Beautiful cutting edge science!
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Fantastic opportunity to work with @AnaVujic5 at @Cambridge_Uni. Ana is doing some really exciting research and would highly recommend. I've been lucky enough to work with Ana and she is a great mentor!
Exciting news! I am recruiting, and looking for a talented Research Assistant. If you're passionate about heart failure and want to be part of an innovative and dynamic research team, I want to hear from you! Link: https://t.co/HnodOYUzgB
@Cambridge_Uni, @Cambridgecardio
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Happy to share our latest work where we show that CISD1/Cisd accumulates in pink1-parkin mutant flies and has an important role in age-related neurodegeneration. Thank you @whitworth_lab @alsanchezmar @MRC_MBU and all the rest of the co-authors! https://t.co/KpD07YWCnU
biorxiv.org
Background Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Functional...
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Pleased to be a small part of a paper just out - led by Amanda Bungaard and Angela Fago - on how turtle hearts avoid ischaemia-reperfusion injury. Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts
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Congrats to Shinpei whose paper is now out. https://t.co/IP1SYfYjgQ
chemistry-europe.onlinelibrary.wiley.com
Triphenylphosphonium (TPP) cation is widely used for selective delivery of compounds into mitochondria. This study demonstrated that the replacement of an alkyl chain with polyethylene glycol (PEG)...
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Fantastic news @AnaVujic5, cannot wait to see the research coming out of the Vujic lab
Huge congratulations to Ana @AnaVujic5 on receiving the prestigious @TheBHF Intermediate Research Fellowship and becoming a PI! Thrilled and very proud of this. @Mito_Redox @Cambridgecardio @MedCambridge @TVPLab
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Follow up on MitoNeoD versus MitoSox. https://t.co/jgujz6RwZW Folks have asked if MitoNeoD/NeoD are available commercially. There do seem to be some suppliers, but to ensure stability of the solid we make it as the HCl salt, which does not seem to be available commercially.
We need to talk about MitoSOX... There are a number of issues with MitoSOX/hydroethidine as "superoxide" probes. One approach from Richard Hartley's lab and mine is to use MitoNeoD/NeoD. Give it a go and let us know if it works for you. https://t.co/ZSxzn9bCmi
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I am looking for a Research Associate to join me at @MRC_MBU to study mitochondrial phospholipids. Please contact me directly for more info if interested! I'd appreciate if you shared this with your network. https://t.co/fEV5oDLUK3
@mitojobs @Cambridge_Uni
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