Raheleh Rahbari
@R_Rahbari
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Cancer Research UK Fellow | Group Leader the @Wellcome Sanger Institute. Interested in mutations acquired during aging and their impact across generation.
Wellcome Sanger intitute
Joined November 2024
II'm excited to finally share our study on the mutational landscape and selection dynamics in sperm, now live on medRxiv: We explored how positive selection impacts mutation rates, especially with age. Here’s a quick thread on our findings! 🧵👇.
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RT @leeat_keren: 🚨Preprint Alert!🚨.Cell classification is one of the most difficult tasks in analyzing spatial data. We present CellTune -….
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RT @genomeresearch: Call for Papers! @genomeresearch is now encouraging submissions for a Special Issue on The Genetics and Genomics of Som….
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RT @naxerova: Interested in the mysteries surrounding metastasis evolution? . This perspective in @NatureRevCancer is my best attempt at pr….
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RT @eventsWCS: Applications are closing on 1 April for our #EBECancer25 course⏰. Our expert trainers and speakers will guide you through ho….
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RT @JohnTadross: 🚨 New paper in @Nature! 🚨.We’ve mapped the human hypothalamus in unprecedented detail, revealing key differences from mice….
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RT @naxerova: Cancer evolution enthusiasts - you might be interested in some new data from our lab on quantifying cell divisions along evol….
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RT @AndyRusss: Excited to share a short article I wrote describing: Slide-tags - which enables spatial single-nucleus sequencing, allowing….
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And of course, we’re deeply grateful to the participants from @TwinsUKres , none of this would be possible without you. 🙏.
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This study reflects years of dedicated work with an incredible team. Special shoutouts to @MDC_Neville for his outstanding work, @imartincorena, @mehurles, @kerrin_small, and all the amazing co-authors involved.
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We made even more interesting findings! Take a look at @MDC_Neville’s tweetorial for a deeper dive:
Excited to share our new preprint in which we address:.(1) Accurate sequencing of sperm at scale.(2) Positive selection of spermatogenesis driver mutations across the exome.(3) Offspring disease risks from male reproductive aging.[1/15].
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We found a subset of genes with no disease link that may influence aging in the seminiferous tubules. These insights deepen our understanding of germline biology and developmental disorders while highlighting unique patterns of selection and mutagenesis across normal tissues.
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Despite the low mutation burden, we found a diverse landscape in sperm, with more than 40 genes under strong positive selection. Most are well-known for causing severe developmental and rare disorders if passed to offspring.
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Using the latest NanoSeq method [, beautifully described by @imartincorena , we conducted deep exome NanoSeq. This allowed us to detect genes under selection in sperm.
Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n
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Building on our previous finding that seminiferous tubules in the testes have a lower somatic mutation burden than other tissues, we set out to answer a new question: what does the driver landscape look like in the male germline?.
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In our previous work, we saw that somatic mutations accumulate almost linearly with age across most tissues. However, there’s substantial variation in mutation burden across tissues, even within the same individual, where exposure-driven differences are minimal.
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RT @doctor_msc: Stem cell transplants are amazing. A patient's diseased blood is replaced by a relative or stranger's. But what does puttin….
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RT @RegevSchweiger: Our new preprint is up - “Insights into non-crossover recombination from long-read sperm sequencing”!. .
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My old account has disappeared, and I'm not sure why. I’m hoping to recover it somehow or link it to my new one! Thank you to everyone for reconnecting!.
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