we must be able to revisit -and learn from- our past, in order to truly be excellent to each other and party on dudes, thanks for coming to my bill and ted talk

Honoured to be invited to speak at this symposium at the Institut Pasteur in Paris! Can't wait to meet old friends and make new ones in the parasite field 😊

Being a part of the Leading Edge community changed my life. Apply to join this incredible group of people!

So happy to see this incredible work on conserved Toxo virulence factors out! Waiting for @prancitorelli to return to London so we can celebrate 🥳

Very grateful and excited to be a part of the Leading Edge community! ☺️ Can't wait to learn and grow from these incredible people.

I was lucky to have attended the inaugural (and very inspiring) Cryptosporidium meeting earlier this year, and really enjoyed contributing to this piece about the session on host-parasite interactions, my favourite thing 😊

it me! honoured to be published in CH&M, and to be finding a home in the #parasitology community (now find me on 🔵🌤️ :D)

Very happy this work is finally out! ☺️ We found some very interesting things about Crypto (the parasite), intraepithelial lymphocytes (first-line gut defenders) and maybe even a potential treatment for this problematic pathogen. Read the article or my linked tweetorial for more!

And because i want to highlight it again, this work would not have been possible without @MuraliMaradana and his incredible understanding of GI immunology. I'm grateful to have been able to work with him, and wish him luck starting his own lab very soon! /The end i promise

Our preprint on dual perturb-seq is now on @biorxivpreprint! Combining pooled CRISPR knockout screening with dual host-pathogen single-cell RNA-seq to identify effector proteins and the host pathways they target https://t.co/ljm5N70RfL

Also also (posting this while on holiday) thanks to everyone @SaterialeLab especially Adam and @TapokaM, and in the Stockinger lab- Oscar Diaz, @NicolaDiny, Ying Li, Anke Liebert for all your gut and AHR-related wisdom!

And if you'd like to stay up to date with more of our Cryptosporidium research to come and general inane socmed content please follow me on the other site that can't be named (in my bio)

We hope this leads to more studies on diet supplementation to treat the most vulnerable at risk of Crypto infection (the very young and malnourished). Please read the full article for more results including neonate protection & crypto as a small intestinal damage model! 8/8

Indole-3-carbinol is a phytochemical enriched in Brassica veggies 🥦🥬 It activates AHR. Supplementing mouse diets with I3C augments their IEL population. So we fed mice I3C and challenged them with Cryptosporidium. They were protected! I went straight home and ate some kale 7/

Amazingly, transferring IELs to immunodeficient mice was enough to rescue them from infection-related morbidity and they had much lower parasite burdens. Go go barrier cytotoxic activity! But what about the indoles? Here's where we got really excited - 6/

Using a series of knockout mouse models, we found that removing AHR expression only in immune progenitor cells produced much higher parasite burdens. We zeroed in on intraepithelial lymphocytes (IELs) as they have high AHR expression and proliferate during a Crypto challenge. 5/

And so, a collaborative project was born. We asked if AHR expression in the small intestine (where crypto exclusively loves to hang out) was also protective. The short, surprising, *Ron Howard voice* answer? It wasn't. The real answer was one layer deeper -- 4/

Why work together? We followed 2 leads: ☝️A 2016 study found fecal indole levels negatively correlated with Crypto infections in humans. ✌️The transcription factor AHR (activated by indoles) is vital for protection/repair after infection/epithelial injury in the mouse colon 3/

At @TheCrick, we had the chance to work with the inimitable Gitta Stockinger and her very persistent & perceptive postdoc @MuraliMaradana. I learned so much from them - not just about gut immunology, but also about generosity and the true collaborative spirit in science. 2/

Connecting the dots is one of the best feelings in research. But with intestinal parasite Cryptosporidium, these dots are often few & far between. So I'm happy to share our preprint connecting crypto, intraepithelial lymphocytes, and potentially, food! 1/ https://t.co/zeMYz8AWZ0

every vaccinia virologist right now