Feedback is welcome! https://t.co/rt7UX3Y64Y

Many thanks to @PMorgaDavid for providing FIB-SEM volume, @CentrioleLab (particularly @louvel_vincent for training on UExM, to Gael Moneron for STED and to @ElectronPasteur and PBI for access to their equipment.

To demonstrate the molecular identity of these densities, Aline used #UExM coupled to STED to reveal that they indeed contain IFT material that displays the same positioning as the densities detected by FIB-SEM

By FIB-SEM, Aline found multiple densities resembling IFT but thinner and shorter than IFT trains encountered on external portions of flagella. Strikingly, they appear to fuse (or split?) and spread along distinct DMT as if they were able to switch from one DMT to another!

dSTORM reveals that IFT proteins are found around all 9 doublet microtubules

How do #trypanosomes restrict #IFT to only 4 doublet microtubules? 2 hypotheses were proposed (restriction @ the flagellum base or @ the injection) but @Aline_A_Alves reveals it is a third way! It all happens in the proximal portion of the flagellum! (BioRxiv link@ end of thread)

Inspiring discussions with paralympic athletes @MParabad, Esteban Herrault, @NantoKeita223 and @tresormakunda @institutpasteur, raising fascinating parallelisms with the challenges we are facing as scientists

Exciting PhD project in the lab of Sue Vaughan at @oxford_brookes University to study #trypanosome basal bodies and flagellum formation https://t.co/TGWh5aXtIz

Congratulations to Jean Marc @JTsagmo who won an Early Career Entomologist Award from the @RoyEntSoc for his PhD work on tsetse fly midgut composition and its possible impact on #trypanosome transmission! 💪 Read more here: https://t.co/twkS8G3snW

Congratulations to our former lab member @DariaJulkowska who was awarded an #Inserm prize for her dedication in coordinating research programs on #rare_genetic_diseases https://t.co/2LPpzLGlrP

🧬 Don’t miss the inspiring keynote by Manu Prakash about #frugalscience and #innovation, renowned biophysicist and innovator during our Adapting to Change conference 👇 @institutpasteur @PrakashLab @IbeidLabex https://t.co/ROILNqW4F3

🌍Explore the frontlines of global health with Peter Hotez! A must-watch conference on vaccines and infectious disease challenges. Dive into the science shaping our world 👇 @institutpasteur @PeterHotez @IbeidLabex https://t.co/0CFt1aaE4C

@microbup Webinar Monday December 16th: TRiP - Therapeutic research in Parasitology - Host: Jérôme Clain - Adrian LUTY: The DeWorm3 Study - Priscilla ADJEI-KUSI @KCCR_GH - Lucille  HERVE @HerveLucille #Parasites register at : https://t.co/9RVmgnoGg6

Excellent opportunity to join Dr Mathieu Cayla's group at the University of York - outstanding mentor and research facility. Please re-post. Postdoctoral Research Associate at University of York

We said goodbye to our lovely Aline @Aline_A_Alves who is heading back to Brazil after 4.5 happy years with us. Watch this space for her manuscripts coming soon!

We are moving to the other side! Join us at @bastinlab.bsky.social We'll keep on posting here for a while, but for now if you want to see images of #trypanosomes after #expansion_microscopy, join us on bluesky 😉

We are recruiting for a postdoc! Deadline is end of the month. https://t.co/bpdxCtk70u Just reach out if you would like to have an informal chat before applying

🚀 Excited to share our first preprint on single-cell transcriptional landscapes of Aedes aegypti with @merkling_lab , exploring dynamic changes in mosquito midgut and abdominal fat body after a bloodmeal. 🦟 https://t.co/oYxcHCmazc

🏆 Didier Ménard, professeur à l’Université de Strasbourg et chercheur à l’Institut Pasteur, est le premier Français à recevoir la médaille Joseph Augustin LePrince de l'@ASTMH ! Une distinction pour son engagement exceptionnel contre le paludisme. #ASTMH2024

Fantastic talk of Peter Myler @seattlechildren browsing through 46 years of science, from Southern blots and cosmid sequencing to RNAseq and alphafold2, with the full base J story! @PIV_IP @institutpasteur #parasitology #Leishmania