Bastin Lab
@BastinLab_Paris
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This account is not updated anymore for obvious reasons. Please find us at https://t.co/9xuaZAe9Wp
Paris, France
Joined October 2018
Many thanks to @PMorgaDavid for providing FIB-SEM volume, @CentrioleLab (particularly @louvel_vincent for training on UExM, to Gael Moneron for STED and to @ElectronPasteur and PBI for access to their equipment.
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To demonstrate the molecular identity of these densities, Aline used #UExM coupled to STED to reveal that they indeed contain IFT material that displays the same positioning as the densities detected by FIB-SEM
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By FIB-SEM, Aline found multiple densities resembling IFT but thinner and shorter than IFT trains encountered on external portions of flagella. Strikingly, they appear to fuse (or split?) and spread along distinct DMT as if they were able to switch from one DMT to another!
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dSTORM reveals that IFT proteins are found around all 9 doublet microtubules
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How do #trypanosomes restrict #IFT to only 4 doublet microtubules? 2 hypotheses were proposed (restriction @ the flagellum base or @ the injection) but @Aline_A_Alves reveals it is a third way! It all happens in the proximal portion of the flagellum! (BioRxiv link@ end of thread)
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Inspiring discussions with paralympic athletes @MParabad, Esteban Herrault, @NantoKeita223 and @tresormakunda @institutpasteur, raising fascinating parallelisms with the challenges we are facing as scientists
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Exciting PhD project in the lab of Sue Vaughan at @oxford_brookes University to study #trypanosome basal bodies and flagellum formation.
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Congratulations to Jean Marc @JTsagmo who won an Early Career Entomologist Award from the @RoyEntSoc .for his PhD work on tsetse fly midgut composition and its possible impact on #trypanosome transmission! 💪 Read more here:.
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Congratulations to our former lab member @DariaJulkowska who was awarded an #Inserm. prize for her dedication in coordinating research programs on #rare_genetic_diseases.
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RT @IbeidLabex: 🧬 Don’t miss the inspiring keynote by Manu Prakash about #frugalscience and #innovation, renowned biophysicist and innovato….
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RT @IbeidLabex: 🌍Explore the frontlines of global health with Peter Hotez!.A must-watch conference on vaccines and infectious disease chall….
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RT @CecileCrosnier: Excellent opportunity to join Dr Mathieu Cayla's group at the University of York - outstanding mentor and research faci….
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We said goodbye to our lovely Aline @Aline_A_Alves who is heading back to Brazil after 4.5 happy years with us. Watch this space for her manuscripts coming soon!
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We are moving to the other side! Join us at @bastinlab.bsky.social.We'll keep on posting here for a while, but for now if you want to see images of #trypanosomes after #expansion_microscopy, join us on bluesky 😉
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RT @samuelddean: We are recruiting for a postdoc! .Deadline is end of the month. Just reach out if you would like t….
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RT @TomPVial: 🚀 Excited to share our first preprint on single-cell transcriptional landscapes of Aedes aegypti with @merkling_lab , explori….
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RT @institutpasteur: 🏆 Didier Ménard, professeur à l’Université de Strasbourg et chercheur à l’Institut Pasteur, est le premier Français à….
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Fantastic talk of Peter Myler @seattlechildren browsing through 46 years of science, from Southern blots and cosmid sequencing to RNAseq and alphafold2, with the full base J story! @PIV_IP @institutpasteur #parasitology #Leishmania
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