DruggableGenome
@DruggableGenome
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Joined May 2017
RT @chem4biology: 8 billion. It's just a number. Today, our 3D tranche browser shows 8 billion* purchasable molecules in biologically relev….
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RT @zenbrainest: Our new peripheral DREADD is now available via @Addgene .Please RT . Paper @CellCellPress here:.ht….
cell.com
Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will...
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RT @zenbrainest: Latest paper from @RothLabUNC .@CanCao_Natural .High-affinity agonists reveal recognition motifs for the MRGPRD GPCR: Cell….
cell.com
MRGPRD is an understudied receptor that lacks high-affinity ligands. In this study, Wang et al. reported two high-affinity agonists that are approximately 100-fold more potent than β-alanine for...
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RT @hongxia_ren: Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors #mdpibiomolecules….
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RT @Asquith__Chris: I'm proud to highlight the recent efforts on TLK2 in @NatRevDrugDisc, including the development of our new selective in….
nature.com
Nature Reviews Drug Discovery - Discover the world’s best science and medicine | Nature.com
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RT @rafeequemavoor: Free scientific illustrations for biologists! 😍. @NIH has released a library of 500+ free scientific illustrations to….
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Come and join us. Starting soon.
Our next CFDE Public Webinar Series is THIS Friday, June 28th from 1-2 PM ET featuring an overview of #IlluminatingTheDruggableGenome (IDG) and the resources they have built as part of the @CfdeNih! Register for the event here:
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RT @NIH_CommonFund: Interested in #proteins and understudied areas of #biology that have a high impact on human health? Tune in this Fri (6….
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Join us on this Friday (6/28) at 1 pm ET for an overview presentation on IDG at the CFDE Webinar Series. Register at this link:
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RT @npburtt: Learn about the Common Fund Data Ecosystem at our first exhibition booth today & tomorrow #FOGBOSTON2024 @NIH_CommonFund @Cfde….
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RT @AviMaayan: On Friday 5/31 @ 1 PM ET, members of the @CfdeWorkbench will introduce new tools to query the @LINCSProgram L1000 data and g….
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RT @zenbrainest: Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine .
jneurosci.org
GPR37L1 is an orphan receptor that couples through heterotrimeric G-proteins to regulate physiological functions. Since its role in humans is not fully defined, we used an unbiased computational...
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RT @NIHDataScience: 🚀 Funding Opportunity Alert! @NIH_CommonFund seeks applications (RFA-RM-24-006) for Pilot Projects enhancing utility &….
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RT @zenbrainest: Why do phosphate-containing medications cause itch? MRGPRX4!.Latest @RothLabUNC @Cannabatopia and Dong Lab (HHMI/Hopkins)….
science.org
Phosphate modification of medications triggers pruritus through the sensory neuron receptor MRGPRX4.
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Looking for ways to learn more about biomedical data? Well how about signing up for an online course offered by CFDE with IDG scientific use cases. Starts June 3rd!.Learn more at:
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RT @NatRevDrugDisc: Our May issue is live! Read about RNA-editing drugs, therapeutics for tuberculosis, small-molecule prodrugs, RNAi-based….
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RT @zenbrainest: Nice blurb from @NIH on our recent paper!.
nih.gov
Scientists uncovered unique structural features of a bitter taste receptor, including a role for cholesterol in receptor activation.
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Check out some more outcomes from IDG in this month's IDG newsletter.
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RT @NIH_CommonFund: Are you a researcher interested in the #proteome? Learn more about a series of articles highlighting resources develope….
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RT @ncats_nih_gov: Are you a researcher interested in the #proteome? Learn more about a series of articles highlighting resources developed….
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