Nature - A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making...

Methods to prepare SF5-containing molecules are of significant interest, as the pentafluorosulfanyl (SF5) group imparts unique chemical and physical properties─such as high electronegativity, and...

Reported herein is the application of a sterically hindered episulfoxide for the modular synthesis of sulfoxides and sulfinamides. SO transfer from the episulfoxide to Grignard or organolithium...

Nature Communications - The understudied lipid kinase PIP4K2C binds SARS-CoV-2 nonstructural protein 6 and regulates virus-induced autophagic flux impairment, suppressing viral protein degradation....

We present a photochemical strategy for transforming 1H- and 2H-indazoles into benzimidazoles, enabling heteroaromatic interconversion under mild conditions. This approach, grounded in a two-step...

Owing to the prevalence of chiral amines in natural products and pharmaceuticals, we developed an iron-catalyzed borrowing hydrogen enantioconvergent amination of alcohols in the presence of chiral...

npj Antimicrobials and Resistance - Strategies and efforts in circumventing the emergence of antiviral resistance against conventional antivirals

We developed a novel nitration method using hypervalent iodine for site-selective C–H functionalization. This technique efficiently synthesizes nitroarenes with high regioselectivity and is scalable,...

Fatty acids are a primary source of carbon for Pseudomonas aeruginosa (PA) in the airways of people with cystic fibrosis (CF). Here, we use tandem mass-tag proteomics to analyse the protein express...

Nature Synthesis - Bioisosteric replacement is vital in drug discovery; however, substituting core ring structures is challenging. Now, a strategy that converts pyridines into benzonitriles, via...