Emil Damgaard Jensen
@damgaard_jensen
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Joined September 2019
a deaminase–helicase (RepA) fusion & a primase (RepB) error-prone DNA polymerase I fusion induce all types of mutation only in the target plasmid
Online now: An in vivo target mutagenesis system for multiple hosts
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Out now from @Alicia_MV_ ! We consolidated a >600 Dutch yeast and characterised their activity against spoilage yeasts and relevant human and plant pathogens, focusing on yeasts that secrete antifungal proteins. Great resource for biocontrol and beyond. https://t.co/jFDgc8wueU
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For users of yeast OrthoRep or any continuous #DirectedEvolution system: After all accessible beneficial synonymous mutations have been made, synonymous ones that just boost expression dominate, creating improvement 'mirages'. Attests to OrthoRep's power! https://t.co/djaXlAqCNS
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living glue system for precise targeting of bleeding sites and prolonged treatment of IBD
Engineered Living Glues for Autonomous Detection and On-Demand Treatment of Inflammatory Bowel Disease https://t.co/bCThhrlStO
#biorxiv_synbio
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Awesome article by Rebeck, Wallace, Prusa, and others from the Dantas Lab @volatilebug showing S. boulardii can be engineered to treat colon cancer in mice! A super hard problem and inspiring for those working on engineered probiotics.
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Our work describing molecular recording of sequential information by directing a chain of insertions with prime editor in mammalian cells is now published in @nchembio here - https://t.co/APV0w8fahi. Congratulations to Theresa Loveless, @CourtneyCarls_n, and the whole team!
nature.com
Nature Chemical Biology - Loveless, Carlson and colleagues describe peCHYRON, a DNA recorder that propagates an unending chain of insertions. Each link contains a randomizable 3-bp...
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True pleasure contributing to this wonderful seminar series and to engage with @timlu & @Moon_Synth_Bio and the participants!
#SynBYSS seminar with Dr. Tim Lu @timlu at Senti Biosciences @SentiBio & Dr. Emil Damgaard Jensen @damgaard_jensen at DTU - Technical University of Denmark @DTUBiosustain @novonordisk The video is below: https://t.co/ttpLhyJmpl via @YouTube
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Congrats @TheDeichmann - excellent performance as usual and a well deserved new title for you. Thank you for the absolutely wonderful 4 years together so far 🙏 Thanks a ton to the evaluation committee @GallowayLabMIT @ProfTomEllis & @CaGuAcRo1
Congratulations @TheDeichmann on completing your PhD studies @DTUBiosustain 🎉💪. It’s been a true adventure & pleasure to work with you & @damgaard_jensen the last 4ys 🙏. I’m excited to follow your next steps. Thx to @GallowayLabMIT @ProfTomEllis & @CaGuAcRo1 for the evaluation
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Accelerating #enzyme discovery and #engineering with high-throughput screening—led by @erayubozkurt @LabNikel @DTUBiosustain @NatProdReports #OpenAccess #SynBio #Biocatalysis
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I’m very happy to share our work on evolving capping T7. Directed evolution of an orthogonal transcription engine for programmable gene expression in eukaryotes
biorxiv.org
T7 RNA polymerase has enabled orthogonal control of gene expression and recombinant protein production across diverse prokaryotic host chassis organisms for decades. However, the absence of 5’ methyl...
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IMPRINT is now out🎉 @MolecularCell Extremely grateful to be part of this exciting collaboration! @BeiselLab @nathanguy14 @barquistlab With this sophisticated method, you can also overcome the barriers to DNA transformation to a variety of bacteria🦠 🧬 https://t.co/A5gaQ21VfO
Having trouble with transforming your favorite bacteria with valuable genetic cargo? Try IMPRINT🙌🏻! A sophisticated TXTL-based pipeline developed by @JustinVento @BeiselLab Fun and long-lasting collaboration between @nathanguy14 @BeiselLab members! Grateful to be part of it☺️
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The Crook Lab is hiring a postdoc in the broad area of gas capture by enzymes! Part of a wonderful collaboration funded by the Novo Nordisk Foundation ( https://t.co/RDf4LCxxaz) Please forward to those who might be interested!
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We are opening a #postdoc position (24 months) to join our group! You are an expert in natural product biosynthesis with molecular biology/yeast/benth skills --> Apply to work in our COMBO project ( https://t.co/4TZvjrvtoD) ! Please RT! #PlantSciJobs @plantpostdocs @AcademicAg
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Enroll in @DTUBiosustain's Advanced Synthetic Biology for Creating Sustainable Cell Factories Summer Course! This course provides extensive theoretical knowledge and practical experience in #SyntheticBiology, #ComputationalBiology, and #MetabolicEngineering.
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@DenizDurmusogl1 @IbrahimAlabri3 and Daniel Haller have just developed a great suite of inducible promoters for probiotic S. boulardii! With them, we can turn recombinant genes on/off, see where Sb is active in the gut, and even alter Sb's colonization!
pubs.acs.org
Saccharomyces boulardii (Sb) is an emerging probiotic chassis for delivering biomolecules to the mammalian gut, offering unique advantages as the only eukaryotic probiotic. However, precise control...
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Last week we published a landmark paper in Nature describing the production of the world's leading vaccine adjuvant, QS-21, in yeast. This work will pave the way for affordable, readily available, effective vaccine adjuvants for the world.
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"Advanced #SynBio for Creating Sustainable Cell Factories", led by @Daniel__Volke & @damgaard_jensen, runs @DTUBiosustain on June 6th-26th · Several hosts (yes, including #Pseudomonas!), in silico-driven design & hands-on experiments included! Apply here:
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In this wonderful collaboration with @CaGuAcRo1 , Frederik & Niklas used chemical neighbourhoods and chemical space neural networks to rapidly infer GPCR drug-classes with just a "home" computer, followed by validation on a highly accurate yeast platform.
biorxiv.org
Drug-target interaction databases comprise millions of manually curated data points, yet there are missed opportunities for repurposing established interaction networks to infer novel drug-target...
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We are recruiting a PhD-level project scientist for our rapid antibody evolution projects and to coordinate the growth of our efforts in this area. Please apply here:
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Outside of me saying absolutely way too much, it’s insightful. Great experience @DrGPCR! Thanks for the opportunity to share my story.
Who would have thought that a class of medical illustration could lead to a life dedicated to science? 😯 Listen to Ep.138 of the @DrGPCR Podcast with Dr. Daniel Isom 🎧 as he talks about the unexpected turn that led him into a career in science ➡️ https://t.co/kKcYdPzkXa
#gpcr
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