Jack Chun-Ting Liu
@ctliu629
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Grad student @sattely_lab @Stanford. Biosynthesis of plant natural products ☘️ Taxol & limonoid. Cyclist when not in lab 🚴🏻♂️
Stanford, CA
Joined October 2023
Really excited to share this work with @conor_mccluneon on Taxol biosynthesis!! 🌲💊
Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a
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Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a
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Excited to share this work that @conor_mcclune and I have been working on! Complete biosynthesis of baccatin III, the semi-synthesis precursor to Taxol🌲 https://t.co/quf94UwspE
biorxiv.org
Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the...
Great job by Conor, Jack, Chloe and Ricardo from the @Sattely_lab in collaboration with the Lange lab and @fordycelab! #plant #stanford #bioengineering
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Delighted that our latest limonoid biosynthetic pathway work is now online @J_A_C_S ! We characterise a yield boosting ⬆️ enzyme involved in an acetyl protection/deprotection step, providing new insights into furan biosynthesis 🍋🌿 https://t.co/5iBG8ttA7l
pubs.acs.org
The furan ring is a defining feature of limonoids, a class of highly rearranged and bioactive plant tetranortriterpenoids. We recently reported an apparent complete biosynthetic pathway to these...
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🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸 Extremely thrilled to *finally* share our work on saponin biosynthesis in soapwort🧼⚕️🌱 @nchembio @JohnInnesCentre @AnneOsbourn1 🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸 https://t.co/72p6sdRMEq
nature.com
Nature Chemical Biology - Soapwort (Saponaria officinalis) is a rich reservoir of triterpenoid glycosides that often have important pharmaceutical, nutraceutical and agronomical potential. Here,...
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Very happy to share our newest publication. By combining diterpene synthases and cytochrome P450 oxygenases from different plant species in yeast, more than 200 diterpenoids could be produced. Project started by @ulschan and completed by Maximilian Frey.
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Special thanks to @Franke_Lab and @v_courdavault for their incredibly helpful feedback during the reviewing process 🙏
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We structurally characterized many side-products of T5aH, and found that lowering expression is beneficial for T5aH’s desired activity. This allows us to reconstitute the early six-step of Taxol biosynthetic network for the first time. (2/2)
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Excited to share my paper @NatureComms on the Taxol biosynthesis @Sattely_lab with some help from the @Keasling_Lab 🥳 🎉 Really happy to have contributed to the studies of this amazing molecule 😊 https://t.co/mpw3frSwVJ (1/2)
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Purifying heterogeneously expressed compound from Nicotiana extract 🌿 all the chlorophylls/pigments always make this a satisfying process 🌈 @Sattely_lab
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While Conor (postdoc working with me on this project) had this gene cloned over 2 years ago, it might take us another full year to screen and find this enzymes, due to the huge amount of candidates genes we have in the freezer.🥲(3/3)
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The third paper on this topic in the past 3 months — just showing how competitive this field is 😅 (2/3)
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Another Taxol biosynthesis paper @ScienceMagazine
https://t.co/UP0se7n3rt My wholehearted congrats to all authors! The discovery of the oxetenase is truly amazing and would greatly facilitate our work. (1/3)
science.org
The biosynthetic pathway of the paclitaxel diterpenoid core baccatin III was artificially reconstructed in tobacco.
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So many amazing talks in the past couple days @CSHLplants! Of course personal favorites are from @AnneOsbourn1 and @OConnor_lab 😆
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