Jack Chun-Ting Liu
@ctliu629
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Grad student @sattely_lab @Stanford. Biosynthesis of plant natural products ☘️ Taxol & limonoid. Cyclist when not in lab 🚴🏻♂️
Stanford, CA
Joined October 2023
Really excited to share this work with @conor_mccluneon on Taxol biosynthesis!! 🌲💊.
Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a.
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RT @conor_mcclune: Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes fro….
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Excited to share this work that @conor_mcclune and I have been working on! Complete biosynthesis of baccatin III, the semi-synthesis precursor to Taxol🌲.
Great job by Conor, Jack, Chloe and Ricardo from the @Sattely_lab in collaboration with the Lange lab and @fordycelab! #plant #stanford #bioengineering.
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RT @HannahHodgson93: Delighted that our latest limonoid biosynthetic pathway work is now online @J_A_C_S !. We characterise a yield boostin….
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RT @jenny_sjo: 🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸🫧🌸. Extremely thrilled to *finally* share our work on saponin biosynthesis in soapwort🧼⚕️🌱. @nchembio @JohnInne….
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RT @trichomeIPB: Very happy to share our newest publication. By combining diterpene synthases and cytochrome P450 oxygenases from different….
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Special thanks to @Franke_Lab and @v_courdavault for their incredibly helpful feedback during the reviewing process 🙏.
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We structurally characterized many side-products of T5aH, and found that lowering expression is beneficial for T5aH’s desired activity. This allows us to reconstitute the early six-step of Taxol biosynthetic network for the first time. (2/2).
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Excited to share my paper @NatureComms on the Taxol biosynthesis @Sattely_lab with some help from the @Keasling_Lab 🥳 🎉.Really happy to have contributed to the studies of this amazing molecule 😊.(1/2).
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Purifying heterogeneously expressed compound from Nicotiana extract 🌿 all the chlorophylls/pigments always make this a satisfying process 🌈 .@Sattely_lab
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While Conor (postdoc working with me on this project) had this gene cloned over 2 years ago, it might take us another full year to screen and find this enzymes, due to the huge amount of candidates genes we have in the freezer.🥲(3/3).
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The third paper on this topic in the past 3 months — just showing how competitive this field is 😅 (2/3).
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Another Taxol biosynthesis paper @ScienceMagazine My wholehearted congrats to all authors! The discovery of the oxetenase is truly amazing and would greatly facilitate our work. (1/3).
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So many amazing talks in the past couple days @CSHLplants!.Of course personal favorites are from @AnneOsbourn1 and @OConnor_lab 😆
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