Daniel Schwartz
@coevolving
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Scientist at DSM. until recently Postdoc with Jay T. Lennon, Indiana University
The Hague, The Netherlands
Joined August 2015
It is my pleasure to share our new research now out in @mbiojournal . Our analysis approach can be used to focus on phage-encoded auxiliary genes important for manipulation of many host traits. 🧵#phage #sporulation #AMG
https://t.co/YgmTkc9yIh.
journals.asm.org
Phages acquire bacterial genes and use them to alter host metabolism in ways that enhance phage fitness. To date, most auxiliary genes replace or modulate enzymes that are used by the host for...
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Thrilled this work is out in @NatureMicrobiol! https://t.co/qoeCpJTAOS (free link here: https://t.co/dbRIiphYZh). We found that bacteria secrete #naturalproducts that sensitize competitors to #bacteriophage.
nature.com
Nature Microbiology - A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.
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My paper with @jaytlennon , "Phage-Encoded Sigma Factors Alter Bacterial Dormancy", was highlighted as an @ASMicrobiology Highly Cited paper in 2024! https://t.co/Kx0wwIpHFb
#ASMJournals Top Cited Articles ( https://t.co/aQ9ApSY9I4)
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I highly recommend joining the lab of @jaytlennon , my former postdoc mentor! His unwavering support for innovative ideas coupled with a playful approach to research ensures not only impactful science but also an enjoyable journey along the way!
Please share: collaborative postdoc opportunity in microbial ecology and evolution @IUBiology: Part of @NSF Biology Integration Institute (BII) on "Genomics and Eco-evolution of Multi-Scale Symbioses (GEMS)” @GEMS_BII: https://t.co/cAjjMIvcx9
https://t.co/BPUJLVS8iN
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Ok, I guess today is the right day to write about our manuscript that was published a month ago in The ISME Journal. This was the outcome of ~ 5 years of hard work of (mainly) Dikla Kolan, who was the first PhD student in my lab (now Dr. Kolan), with some help from
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Streptomyces vs Bacillus👇🏼 “The phage-promoting metabolite, coelichelin, sensitized B. subtilis to a wide panel of lytic phages, and it did so by preventing the early stages of sporulation through iron sequestration. “
Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection https://t.co/4zpH0fxHez
#biorxiv_micrbio
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Another update... after nearly 10 years in development, delighted to share news that 'Quantitative Biosciences: Dynamics across Cells, Organisms, and Populations' is available for pre-order from @PrincetonUPress: https://t.co/mio83U7RBU
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Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection https://t.co/4zpH0fxHez
#biorxiv_micrbio
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If you are interested how preculture conditions prepare Lactococcus cremoris for future sugar consumption have a look at a proteome study by S. Douwenga, Berdien van Olst, Michiel Kleerebezem, @BasTeusink ..@JournalSpectrum
https://t.co/mSk2WsKVDk
journals.asm.org
The availability of nutrients to microorganisms varies considerably between different environments, and changes can occur rapidly. As a general rule, a fast growth rate—typically growth on glucose—is...
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“Evolution of a minimal cell” in @Nature: https://t.co/LxEyxhaZfo Led by @RoyBoy432 with Brent Lehmkuhl at @IUBiology
@JCVenterInst collaborators: Lijie Sun, Daniela Bittencourt, Kim Wise, John Glass Along with @dschoolmaster, and Mike Lynch @ASUBiodesign
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Choanoflagellates alongside diverse uncultured predatory protists consume the abundant open-ocean cyanobacterium Prochlorococcus
pnas.org
Prochlorococcus is a key member of open-ocean primary producer communities. Despite its importance, little is known about the predators that consum...
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Bacteria-phage coevolution with a seed bank
nature.com
The ISME Journal - Bacteria-phage coevolution with a seed bank
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“Bacteria-phage coevolution with a seed bank” Led by @coevolving with @ShoeStrapped, @AndreeaMagalie, @joshuasweitz available @ISMEJournal 🧵 https://t.co/ukkloLDfvK
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I am proud to see my final first-author from my postdoc research with @jaytlennon now published in @ISMEJournal. Congratulations and many thanks to all coauthors and many other people that helped along the way.
Bacteria-phage coevolution with a seed bank @ISMEJournal by @coevolving @ShoeStrapped @AndreeaMagalie @joshuasweitz and @jaytlennon
#Bacillussubtilis #SPO1
https://t.co/xH59v7ubip
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Bacteria-phage coevolution with a seed bank @ISMEJournal by @coevolving @ShoeStrapped @AndreeaMagalie @joshuasweitz and @jaytlennon
#Bacillussubtilis #SPO1
https://t.co/xH59v7ubip
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Congratulations to @coevolving on their new paper in @mbio documenting sporulation genes in phages. More importantly, congratulations to @coevolving on the new microbiology job @DSM with move to the Netherlands! It was great having you here @IUBiology!
Human-gut phages harbor sporulation genes https://t.co/6zpoxZ7cxv
@jaytlennon @coevolving @mikerobiome @reb_daly @jrr_microbio @kcwrighton #mBio
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Human-gut phages harbor sporulation genes https://t.co/6zpoxZ7cxv
@jaytlennon @coevolving @mikerobiome @reb_daly @jrr_microbio @kcwrighton #mBio
journals.asm.org
Phages acquire bacterial genes and use them to alter host metabolism in ways that enhance phage fitness. To date, most auxiliary genes replace or modulate enzymes that are used by the host for...
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Please see our (short) paper for more details on how we achieved this and what we found. Thank you and congratulations to all coauthors! @jrr_microbio @mikerobiome Rory Flyn @reb_daly @kcwrighton @TheWrightonLab @jaytlennon
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This approach can be used to focus attention and identify phage auxiliary genes that are more likely to actually influence and interact with any host trait or pathway that is limited in scope among bacteria.
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