Chekan Lab
@ChekanLab
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Assistant Professor UNC Greensboro | Natural Products | Biosynthesis | Genome Mining | Enzymology
Joined January 2020
Out now in @Chem_CP , we collaborate with @piel_lab to discover a prenyltransferase+terpene cyclase fusion enzyme that modifies Trp residues in RiPPs to yield complex steroid-like scaffolds! Congrats to @HubrichFlorian, @sanathrajkk0 for leading this!🎉 https://t.co/2TGkSQzbfq
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The #BJOC thematic issue on Young investigators in natural products chemistry, biosynthesis, and enzymology is now complete! 31 contributions from young investigators around the world! Check it out! @BeilsteinInst
https://t.co/a4mYvyDF6x
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Thrilled to share our work on the new plant Cu enzymes, BpCs! We offer mechanistic insights and structural recommendations for advancing BpC research. Thanks to @jess_panch for inviting us to publish in @TrendsChemistry ! 🌿🧬🧪 https://t.co/U87qKS5TFK
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When the standard approaches didn't work, @Chad46971777 came up with a new one to solve a synthetic challenge that @YeWangum was having. Mix in @AzamHussai70792 and the following @J_A_C_S paper was the result. @NarayanLab @MichiganChem @UMLifeSciences #biocatalysis
Ancestral Sequence Reconstruction to Enable Biocatalytic Synthesis of Azaphilones | Journal of the American Chemical Society @AlisonNarayanUM
@UMichResearch @UMich @NarayanLab #Ancestral #Sequence #Reconstruction #Biocatalysis #Azaphilones
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We studied rSAM, HtkB catalyze a His-to-Lys crosslink, and revealed conserved active site residues that influence substrate specificity. Brandon Morinaka Lab | RSC Chem Biol https://t.co/h1qBAjsiYL
pubs.rsc.org
Radical SAM cyclophane synthases catalyze C–C, C–N, and C–O crosslinking reactions in the biosynthesis of bioactive peptide natural products. Here, we studied an uncharacterized rSAM enzyme, HtkB...
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Come join our awesome team @uncg_chem @UNCG. We are seeking a new colleague to teach organic chemistry to our absolutely amazing students! Please rt 🙏🧪⚗️🌞
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Our dept of Chem&Biochem is hiring an Asst Prof in the areas of Inorganic/Bioinorganic Chem. We are an R2 that combines exceptional research with mentorship and teaching of a diverse student population. Come join our fantastic community! #chemjobs
https://t.co/tI97sE7nnK
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Calling all Inorganic Chemists. Join our amazing department with a tenure track Assistant Professor position. I love @uncg_chem. Great colleagues, remarkable students, low cost of living. Check us out! https://t.co/Dp88Iqpsx1
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My amazing department, @bio_uncg, is hiring an Assistant Professor in Genetics/Cell Biology! Since starting @UNCG, I've felt incredibly supported and can't speak highly enough of this department! Please retweet and share with colleagues! https://t.co/Um4tSSHzSx
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Delighted that a collaboration with @Nairlab_UIUC is now online @nchembio Nucleobases are common in biology but not in peptides. In this work, a nucleobase-peptide hybrid is generated from a ribosomal precursor peptide via YcaO domain protein catalysis.
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Never underestimate a diiron enzyme. Congrats @sanjoyadak90 for bringing the nitrile synthase AetD to life with @Drennan_lab, Maria-Eirini Pandelia, and Ken Houk labs. Published today @NatureChemistry
nature.com
Nature Chemistry - Nitrile-containing molecules and their biosynthetic enzymes are uncommon in nature. Now, a nitrile-forming diiron enzyme involved in the biosynthesis of aetokthonotoxin—the...
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Congrats to @HubrichFlorian & @sanathrajkk0 for this exciting story finally being published. Thanks for the fruitful collaboration with @chekanlab. If you are interested in the chemical space of #RiPP #biosynthetic #enyzmes and #isoprenoids, click here: https://t.co/LGXC9ier8Z
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It was great working with you on this exciting project!
Very excited to share that one of the major projects from my postdoc in the wonderful @piel_lab is out now @Chem_CP. An amazing collaboration with the @ChekanLab and @sanathrajkk0 where we characterized RiPPs with polycyclic isoprene moieties🎉
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So excited that @uncg_chem has been awarded the 2024 @UNCG_CAS Diversity Award. Join us in person or virtually, September 10th at 3:30 EDT, to share ideas about inclusiveness in science. DM me for a link https://t.co/csrtyKoNHB
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Thrilled to have accomplished a major career goal nearly 15 years in the making today! I showed my biochem class the 1971 stanford protein synthesis video.
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Out now in @ACSCatalysis, we develop a chimeric fusion N-glycosyltransferase for targeted and selective peptide modification, especially in vivo. We use it to make a new glycocin derivative (RiPP NP). Congrats to @smith_ayoola for leading this work!🎉 https://t.co/3RjGOrPhvV
pubs.acs.org
Many biosynthetic enzymes involved in the production of ribosomally synthesized and post-translationally modified peptides (RiPPs) in prokaryotic organisms often possess two distinct functional...
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🔓Take a look in our latest issue at this #OpenAccess article by Jonathan Chekan, Roland Kersten & co @ChekanLab @kersten_lab highlighting the chemistry, biosynthesis & function of plant RiPPs 📍@uncg_chem @UMichPharmacy
https://t.co/IKwB3SM4Hf
pubs.rsc.org
Covering 1965 to February 2024 Plants are prolific peptide chemists and are known to make thousands of different peptidic molecules. These peptides vary dramatically in their size, chemistry, and...
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Excited to share our latest work on a new subfamily of VHPOs that modify external AQ molecules and rescue bacterial growth! @JacksonBaumga10 drove this interdisciplinary effort with amazing MS imaging support from @nerdcitycat and @DrLauraSanchez! https://t.co/pPw7atzRGv
biorxiv.org
Site-selective vanadium-dependent haloperoxidases (VHPOs) are a unique enzyme family that catalyze selective halogenation reactions previously characterized within bacterial natural product biosynt...
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Out now: We reassemble 700 public plant transcriptomes to mine potential for side chain crosslinked peptides in plants (burpitides). We found multiple phylogenetic hot spots supported by metabolomics. Congrats to Draco, @mikepasquale77, and Brigitte! https://t.co/PMkp3X6JTQ
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