Keep calm and apply Bayes' Rule.

RT @thjashin: Autoregressive models are too restrictive by forcing a fixed generation order, while masked diffusion is wasteful as it fits….

Proud to share a big step toward building systems that help us simulate and predict the behavior of cells!. GREmLN is a graph-based transformer model, designed to reason across biological data by embedding gene regulatory network architecture directly into its attention.

Fun write up by @ElliotHershberg on virtual cells.

ICML 25 paper on variational guidance for diffusion models accepted. Happy to share that our diffusion model guidance paper with @farrinsofian, @kpandey008, @felixDrRelax, and @StephanMandt on casting control for guidance as variational inference with auxiliary variables was.

Is this the greek version of Wrexham?.Go @kostascrypto !.

Of course a deeper error analysis here will eventually reveal what actually works and why, and whether it captures perturbations or just basal states very well, but I really enjoy seeing these little results and explorations.

And the result!

And Virtual Cell Platform entry:. 4/4.

And our paper:. 3/4.

Adding our model overview again:. 2/4.

Thanks to the @tahoe_ai hackathon and the amazing team that did the OODyssey work I learned sth new about our recently released Transcriptformer model: .It did well in the wild on disease-relevant, unseen (in this case cellular drug perturbation) data that they use for their drug.

RT @cziscience: TranscriptFormer is a new AI model trained on millions of cells from 12 different species, spanning 1.5 billion years of ev….

Model overview:

Paper:

Proud to share TranscriptFormer - a generative model for single-cell transcriptomics, trained on 112 million cells across 12 species spanning 1.5 billion years of evolution. TranscriptFormer is distinct in being both generative and multi-species. Built entirely on raw gene.

RT @zavaindar: long public biotech. long early stage AI and infra.

RT @nalidoust: Meet the judges & mentors for the Tahoe Deep Dive Hackathon & thanks @awscloud for offering the prize: $25K AWS credits to w….

RT @zavaindar: We're launching ACHIRA, a newco DIMENSION cofounded alongside @jchodera & @tkaraletsos. We're building foundation simulation….

I also want to point out how exciting it is to be part of two concurrent revolutions in AI in the life sciences between the virtual cell work we pioneer at @cziscience and the AI for atomistic simulations for drug discovery with Achira. Chemistry and biology are inextricably.

We are very excited for the enthusiastic support from @_DimensionCap , @AmplifyPartners , @nvidia , and @CompoundVC who are all bought in to the impact this work will bring.