Perrimon Lab
@PerrimonLab
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Dr. Norbert Perrimon's lab at Harvard Medical School researches functional genomics, cell circuitry, and tissue homeostasis in Drosophila melanogaster.
Boston, MA
Joined December 2017
https://t.co/ZSXB50OycS Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research
thecrimson.com
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research | News | The Harvard Crimson
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Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon bioRxiv 2025.08.08.669325; doi:
biorxiv.org
Coenzyme A (CoA), derived from Vitamin B5 (VB5), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well characterized, its...
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A Genome-wide CRISPR Screen Reveals ZDHHC8-Dependent Gαq Palmitoylation as a Key Regulator of GPCR Signaling Muhammad Ahmad, Norbert Perrimon, Raghuvir Viswanatha, Ah-Ram Kim bioRxiv 2025.08.06.668953; doi:
biorxiv.org
G protein-coupled receptors (GPCRs) that couple to the Gαq signaling pathway control diverse physiological processes, yet the full complement of cellular regulators for this pathway remains unknown....
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Cheng, C., Liu, Y., Chen, Y., Li, J., Xu, W., Perrimon, N. and Song, W. (2025) The power of Drosophilain modeling cancer cachexia. Adv Exp Med Biol. 482:83-100. doi: 10.1007/978-3-031-97035-1_5. PMID: 40745137
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Intersecting experimental evolution and CRISPR screens to identify novel insecticide resistance loci Marconcini, Cruchet, Goswami, Viswanatha, Butnaru, De, Roselli, Hadjieconomou, Perrimon, Mohr, Benton bioRxiv 2025.07.23.666417; doi:
biorxiv.org
Understanding toxin resistance in insects is key to appreciate niche adaptations and for pest management, but remains challenging due to complex genetics. To investigate how Drosophila sechellia...
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Qadiri, e (2025) FlyPhoneDB2: A Computational framework for analyzing cell-cell communication in Drosophila scRNA-seq data integrating AlphaFold-Multimer predictions. Comput Struct Biotechnol J. 27:2814-2822. doi: 10.1016/j.csbj.2025.06.032.
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New paper: Song, Y., Hu, Y., Dow, J., Perrimon, N. and Papatheodorou, I. (2025) ScGOclust: leveraging gene ontology to find functionally analogous cell types between distant species. Bioinformatics. 4:i571-i579. doi: 10.1093/bioinformatics/btaf195. PMID: 40662793
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New Paper: Viswanatha , Entwisle, Hu, Kim, Reap, Butnaru, Qadiri, Mohr, Perrimon. Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) Nature Communications https://t.co/LmtbB1T17h
nature.com
Nature Communications - Genome-wide CRISPR screens map how genes support survival and contribute to diverse biological functions. Here, the authors use antiCRISPR to enhance genome-wide CRISPR...
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New paper: Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking Bosch et al. doi:
biorxiv.org
Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the “secretome”, along with their tissues of...
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New paper: Cholinergic Signaling Modulates Intestinal Pathophysiology in a Drosophila Model of Cystic Fibrosis Elizabeth Lane, Afroditi Petsakou, Ying Liu, Weihang Chen, Mujeeb Qadiri, Yanhui Hu, Norbert Perrimon doi:
biorxiv.org
Cystic Fibrosis (CF) is a monogenic genetic disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride/bicarbonate channel, which is expressed in certain...
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New paper: Ben Ewen-Campen, Weihang Chen, Sudhir Gopal Tattikota, Ying Liu, Yanhui Hu, Norbert PerrimonThe Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth doi:
biorxiv.org
The Drosophila proventriculus is a bulb-shaped structure at the juncture of the foregut and the midgut, which plays important roles in ingestion, peritrophic membrane synthesis, and the immune...
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Protein folding stress transcriptionally reprograms muscle metabolism Jacob Paiano, Mujeeb Qadiri, Suhasini Sharma, Yanhui Hu, Norbert Perrimon doi:
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Kang et al. (2025) NF-κB-mediated developmental delay extends lifespan in Drosophila PNAS. 122(19):e2420811122. doi: 10.1073/pnas.2420811122.
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Xiao, G. et al. (2025). Intratumor HIF-1a modulates production of a cachectic ligand to cause host wasting. Cell Insight. doi: 10.1016/j.cellin.2025.100247. PMID: 40336592
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TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. Hu Y, Rodiger J, Liu Y, Gao C, Liu Y, Qadiri M, Veal A, Bulyk ML, Perrimon N. Genetics. 2025 doi: 10.1093/genetics/iyaf082. PMID: 40314147
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Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice. Liu, Dantas, Ferrer, Miao, Qadiri, Liu, Comjean , Davidson, Perrier, Ahmed, Hu, Goncalves, Janowitz, Perrimon. Nat Metab. 2025 doi: 10.1038/s42255-025-01265-2. PMID: 40275022
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