Perrimon Lab
@PerrimonLab
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Dr. Norbert Perrimon's lab at Harvard Medical School researches functional genomics, cell circuitry, and tissue homeostasis in Drosophila melanogaster.
Boston, MA
Joined December 2017
New paper: Cholinergic Signaling Modulates Intestinal Pathophysiology in a Drosophila Model of Cystic Fibrosis.Elizabeth Lane, Afroditi Petsakou, Ying Liu, Weihang Chen, Mujeeb Qadiri, Yanhui Hu, Norbert Perrimon.doi:
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New paper: Ben Ewen-Campen, Weihang Chen, Sudhir Gopal Tattikota, Ying Liu, Yanhui Hu, Norbert PerrimonThe Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth.doi:
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Protein folding stress transcriptionally reprograms muscle metabolism. Jacob Paiano, Mujeeb Qadiri, Suhasini Sharma, Yanhui Hu, Norbert Perrimon.doi:
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Kang et al. (2025) NF-κB-mediated developmental delay extends lifespan in Drosophila PNAS. 122(19):e2420811122. doi: 10.1073/pnas.2420811122.
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Xiao, G. et al. (2025). Intratumor HIF-1a modulates production of a cachectic ligand to cause host wasting. Cell Insight. doi: 10.1016/j.cellin.2025.100247. PMID: 40336592.
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TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. Hu Y, Rodiger J, Liu Y, Gao C, Liu Y, Qadiri M, Veal A, Bulyk ML, Perrimon N. Genetics. 2025 doi: 10.1093/genetics/iyaf082. PMID: 40314147.
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Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice. Liu, Dantas, Ferrer, Miao, Qadiri, Liu, Comjean , Davidson, Perrier, Ahmed, Hu, Goncalves, Janowitz, Perrimon. Nat Metab. 2025 doi: 10.1038/s42255-025-01265-2. PMID: 40275022.
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Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth by promoting tracheogenesis. Kerui Huang, Ting Miao, Ezequiel Dantas, Myeonghoon Han, Yanhui Hu, Keven Wang, Jack Sanford, Marcus Goncalves, Norbert Perrimon.doi:
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Simonian, Meyer, Guo, Sha, Wohlschlegel, Droujinine, Perrimon, McMahon (2025) Sex and depot specific adipocyte proteome profiling in vivo via intracellular proximity labeling. Comprehensive Physiology. 15(2):e70007. doi: 10.1002/cph4.70007. PMID: 40181252.
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TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. Hu, Rodiger, Liu, Gao, Liu, Qadiri, Veal, Bulyk, Perrimon.
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The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration.Joshua Shin Shun Li, Liu, Kim, Qadiri, Xu, Xia, Binari, Asara, Hu, Perrimon.bioRxiv 2025.01.16.633419; doi:
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Virtual seminar series that the US National Cancer Institute (NCI) is holding on non-mammalian models of cancer.
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Cell-death induced immune response and coagulopathy promote cachexia in Drosophila. Ankita Singh, Yanhui Hu, Raphael Fragoso Lopes, Liz Lane, Hilina Woldemichael, Charles Xu, Namrata D. Udeshi, Steven A. Carr, Norbert Perrimon.doi:
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Colorectal tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms.Afroditi Petsakou, Elizabeth Filine, Matthew Li, Alice Zheng, Norbert Perrimon.doi:
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Phage-displayed synthetic library and screening platform for nanobody discovery.Baolong Xia, Ah-Ram Kim, Feimei Liu, Myeonghoon Han, Emily Stoneburner, Stephanie Makdissi, Francesca Di Cara, Stephanie E. Mohr, Aaron M. Ring, Norbert Perrimon.doi:
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Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila. Li J, Huang K, Dibra I, Liu Y, Perrimon N, Simons M. 2024 11:rs.3.rs-5566817. doi: 10.21203/rs.3.rs-5566817/v1. PMID: 39711529.
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CESA: Cross-species Epitope Sequence Analysis for discovery of existing antibodies useful for phospho-specific protein detection in model species. Yanhui Hu, Chenxi Gao, William McKenna, Baolong Xia, Majd Ariss, Stephanie Mohr, Norbert Perrimon.doi:
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