Perrimon Lab
@PerrimonLab
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Dr. Norbert Perrimon's lab at Harvard Medical School researches functional genomics, cell circuitry, and tissue homeostasis in Drosophila melanogaster.
Boston, MA
Joined December 2017
Huang, K. and Perrimon, N. (2025) Metabolic command centers in Drosophila: How the fat body and oenocytes orchestrate immunity, reproduction, and aging. Current Opinion in Insect Science. 101459. doi: 10.1016/j.cois.2025.101459. PMID: 41218693
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New paper Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila Han, Xia, Ah-Ram Kim, Filine, Stoneburner, Miao, Liu, Zirin, Perrimon bioRxiv 2025.10.31.685841; doi:
biorxiv.org
Circulating hormones, that mediate communications across organs to maintain physiological balance, are commonly detected and quantified using enzyme-linked immunosorbent assays (ELISAs). However,...
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New paper: A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome Kim, Huang, Johnson, Yaron-Barir, Keven Wang, Cantley, Hu, Perrimon bioRxiv 2025.10.10.681672; doi:
biorxiv.org
Protein kinases orchestrate cellular processes through phosphorylation, yet the structural basis for their specific binding partner interactions remains largely unmapped. Here, we present a structu...
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New paper: A family of lethal exotoxins defined by cell entry via the Attractin receptor Viswanatha, Lee, Robins, Mameli, Hu, Kim, Hashmi, Hiroshi , Prakash, Butnaru, Churchman, Mohr, Mekalanos, Perrimon doi:
biorxiv.org
Although bacterial genomes encode numerous potential toxins, it is unclear how evolution drives the specificity of these important virulence factors. Using an insect CRISPR screen, we identified the...
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New paper: Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer Liu, Miao, Wang, Ezequiel, Kim, Zhang, Sun, Binari, Asara, Hu, Goncalves, Janowitz, Perrimon doi:
biorxiv.org
Paraneoplastic syndromes arise when tumor-derived cytokines reprogram distant organs. Although mediators such as Interleukin-6 have been implicated, how these signals impair host organ function...
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https://t.co/ZSXB50OycS Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research
thecrimson.com
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research | News | The Harvard Crimson
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Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon bioRxiv 2025.08.08.669325; doi:
biorxiv.org
Coenzyme A (CoA), derived from Vitamin B5 (VB5), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well characterized, its...
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A Genome-wide CRISPR Screen Reveals ZDHHC8-Dependent Gαq Palmitoylation as a Key Regulator of GPCR Signaling Muhammad Ahmad, Norbert Perrimon, Raghuvir Viswanatha, Ah-Ram Kim bioRxiv 2025.08.06.668953; doi:
biorxiv.org
G protein-coupled receptors (GPCRs) that couple to the Gαq signaling pathway control diverse physiological processes, yet the full complement of cellular regulators for this pathway remains unknown....
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Cheng, C., Liu, Y., Chen, Y., Li, J., Xu, W., Perrimon, N. and Song, W. (2025) The power of Drosophilain modeling cancer cachexia. Adv Exp Med Biol. 482:83-100. doi: 10.1007/978-3-031-97035-1_5. PMID: 40745137
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Intersecting experimental evolution and CRISPR screens to identify novel insecticide resistance loci Marconcini, Cruchet, Goswami, Viswanatha, Butnaru, De, Roselli, Hadjieconomou, Perrimon, Mohr, Benton bioRxiv 2025.07.23.666417; doi:
biorxiv.org
Understanding toxin resistance in insects is key to appreciate niche adaptations and for pest management, but remains challenging due to complex genetics. To investigate how Drosophila sechellia...
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Qadiri, e (2025) FlyPhoneDB2: A Computational framework for analyzing cell-cell communication in Drosophila scRNA-seq data integrating AlphaFold-Multimer predictions. Comput Struct Biotechnol J. 27:2814-2822. doi: 10.1016/j.csbj.2025.06.032.
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New paper: Song, Y., Hu, Y., Dow, J., Perrimon, N. and Papatheodorou, I. (2025) ScGOclust: leveraging gene ontology to find functionally analogous cell types between distant species. Bioinformatics. 4:i571-i579. doi: 10.1093/bioinformatics/btaf195. PMID: 40662793
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New Paper: Viswanatha , Entwisle, Hu, Kim, Reap, Butnaru, Qadiri, Mohr, Perrimon. Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) Nature Communications https://t.co/LmtbB1T17h
nature.com
Nature Communications - Genome-wide CRISPR screens map how genes support survival and contribute to diverse biological functions. Here, the authors use antiCRISPR to enhance genome-wide CRISPR...
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New paper: Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking Bosch et al. doi:
biorxiv.org
Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the “secretome”, along with their tissues of...
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New paper: Cholinergic Signaling Modulates Intestinal Pathophysiology in a Drosophila Model of Cystic Fibrosis Elizabeth Lane, Afroditi Petsakou, Ying Liu, Weihang Chen, Mujeeb Qadiri, Yanhui Hu, Norbert Perrimon doi:
biorxiv.org
Cystic Fibrosis (CF) is a monogenic genetic disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride/bicarbonate channel, which is expressed in certain...
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New paper: Ben Ewen-Campen, Weihang Chen, Sudhir Gopal Tattikota, Ying Liu, Yanhui Hu, Norbert PerrimonThe Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth doi:
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