alexander.belyy
@alexanderbelyy1
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Assistant professor, University of Groningen, NL. Studying bacterial toxins and actin cytoskeleton using cryo-EM. Dancing boogie-woogie and lindy hop.
Groningen, NL
Joined February 2020
In our new article, we show how P. aeruginosa, a major cause of chronic respiratory infections in #cysticfibrosis (CF), uses the Type VI Secretion System #T6SS and specific #toxins to eliminate competing bacteria https://t.co/LWt03IY9Lj
#cryoEM @DmitryShatskiy
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Thrilled to be one of 12 awardees of the prestigious #ERCStG from the LS1 panel this year! Over the next five years, we’ll study how intracellular bacterial pathogens manipulate #actin to spread infection, with the aim of finding ways to stop them. Exciting times ahead!
Warm congratulations to new LS1 @ERC_Research grantees 🥳🥳Tom DENDOOVEN (@structbiolbxl), @MartinPacesa, @MMSchuhmacher, @LFMilles, @preinerin, @MarkusHopfler, @CharleneBoumen1, @AffProf, @ShifraLansky, @alexanderbelyy1, Erik Benson (@scilifelab), @daniel_bojar! #ERCStG
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Structure of the F-tractin-F-actin complex. A new study by Dmitry Shatskiy (@DmitryShatskiy), Athul Sivan, Roland Wedlich-Söldner (@RolandSoldner), and Alexander Belyy (@alexanderbelyy1) https://t.co/wRybMcuoBv
#Cytoskeleton #StructuralBiology #Biochemistry #Actin
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Using F-tractin to visualize #actin in living cells? @DmitryShatskiy, Athul Sivan, @RolandSoldner and @alexanderbelyy1 determined the F-tractin-F-actin structure and showed that this probe is nearly identical to #Lifeact. https://t.co/iYmncHDYuA
#cytoskeleton
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Many thanks to @DmitryShatskiy, Athul Sivan, and @RolandSoldner for the excellent work! #Actin #Ftractin #Cytoskeleton #Microscopy #StructuralBiology #CryoEM #Science
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Finally, based on the structural data, we designed an optimized version of F-tractin. The result? Great labeling and minimal disturbance to actin dynamics! 🚀
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These structural results and the biochemical data show that the previously reported differences between these peptides originate from the flexible areas of F-tractin or from differential expression levels, rather than from fundamentally different modes of interaction with F-actin
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Unexpectedly, this binding site is nearly identical to the one of #Lifeact - the most popular probe for visualization of actin in living cells!
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Using cryo-EM 🔬, we determined the structure of the F-tractin–F-actin complex at high resolution. We found its specific binding site, which explained its actin-binding properties! Check out these structural insights! 📸
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F-tractin is a small peptide derived from the rat ITPKA protein that binds F-actin. It’s a go-to tool for actin #cytoskeleton visualization in live cells. But… how does it work at the molecular level? 🤔🔍
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Are you doing cell #biology? Then, let me guess, you likely stained #actin! Our @JCellBiol article reveals the structure of the popular actin probe F-tractin in complex with F-actin and introduces an optimized version for better imaging! A thread! 👀👇 https://t.co/znFqcHQMxe
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We are pleased to announce that ETOX 2025, the 22nd European Workshop on Bacterial Protein Toxins, will be held in Spain, June 29 - July 3, 2025. Registration opens on January 6. Apply here https://t.co/2UjN0eiXxL and join us for a great meeting! Please retweet. @AlbesaJove
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Using #Ftractin to visualize #actin in living cells? We determined the F-tractin-F-actin structure and showed that the probe is nearly identical to #Lifeact. Check out light microscopy by Athul Sivan @RolandSoldner and #cryoEM by @DmitryShatskiy and me https://t.co/xdUooVyzhy
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‘Dynamic’ start 2nd day @ZernikeInst chaired by Michael Lerch,cryo-EM @alexanderbelyy1 , @MKEspinozaC, Vasista & @jamanazmin
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Exciting news! I'm looking for talented individuals to join my soon-to-be-launched Emmy Noether group supported by @dfg_public and @UniOsnabrueck! Reach out if you're passionate about #cryoEM and #photosynthesis! https://t.co/y5hEnKcYKi
https://t.co/xZc5tpo4yE
#ScienceJobs
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Today, April 1, I am joining the university's building construction team! I can't wait to share my knowledge of the actin cytoskeleton for the development of the Zernike campus!
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Mark's tour-de-force work shows that the ABC transporter BacA from Mycobacterium mediates unprecedented bi-directional transport of cobalamin. Great team effort with Solène and @chancie_t (Chancie) https://t.co/5kApEa5OXl
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Looking for a PhD student to join my group studying bacterial virulence factors using cryo-EM, advanced biochemistry, and molecular biology. Modern environment, amazing colleagues, and a lively city in the Top of the Netherlands! Apply: https://t.co/DCIzFW9r7q
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Check out our manuscript in @NatureComms
https://t.co/fwD4DPDu5W and a great press release by @mpimoph
https://t.co/TqAGquvwFF And you know what, this toxin has an amazing little sister - Mcf2 – stay tuned!
mpi-dortmund.mpg.de
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This was the effort of the fantastic @mpimoph team. Great work was done by @HeilenPhilipp! Huge thanks to twitterless Oliver Hofnagel and Philine Hagel. And, special thanks to @Intein for the invaluable guidance, support, and motivation! Working together has been a real pleasure!
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