RT @VanderbiltCSB: New work from @ZhongyueY, @ajlinklab and Yi-Lei Zhao takes a first step toward structural prediction of RiPPs: lasso pep….

RT @ZhongyueY: Our first step toward structural prediction of RiPPs: lasso peptide. This tool can be accessed from….

This is a fun example of how enzymes we find in curiosity-driven natural products research can turn into potentially useful biocatalysts. Congrats to all of the authors!.

The latest Link lab paper is out @ACSCentSci : ! In this work, led by @bsmchoi and @TobyJohnson144 we show that an ATP-grasp enzyme from #RiPP biosynthesis can be repurposed to cyclize peptides and even proteins!.

RT @ZhongyueY: Things tend to slow down in winter, but Elsa Ding and Yaoyukun Jiang from our group have engineered a 'cold-adapted' version….

RT @yitang_ucla: In a year with so little to cheer about so far, I am happy to share our manuscript on a copper-dependent halogenase. Unbe….

There are 56 predicted cysimiditides scattered around actinobacterial genomes. We originally found some cysimiditides as part of our study on imiditides, linear peptides harboring an aspartimide:

The latest Link lab paper is out @BiochemistryACS!: This work, led by Angela Zhu, focuses on the cysimiditides, a new subfamily of #RiPPs. The cysimiditides include a tetracysteine motif that coordinates a zinc ion and a single aspartimide moiety.

RT @biorxiv_biochem: Cysimiditides: RiPPs with a Zn-tetracysteine motif and aspartimidylation #biorxiv_biochem.

RT @piel_lab: Congrats to @HubrichFlorian & @sanathrajkk0 for this exciting story finally being published. Thanks for the fruitful collabor….

RT @NinaHartrampf: Thank you for highlighting our work on the chemoenzymatic synthesis of modified lasso peptides on the covers of @J_A_C_S….

RT @ZhongyueY: AlphaFold can't tell you the structure of lasso peptide, a major branch of RiPPs and promising antibiotics. Xingyu wasn't ha….

RT @DrewCarson712: Excited to be at @BostonBacteria at Boston Univ! Looking forward to some great science #BBM2024 🧫 I’m presenting poster….

RT @NinaHartrampf: Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in @J_A_C_S! We used flow-SPPS to synthesize s….

RT @yitang_ucla: Early Announcement!.Together with Brad @BradMoore_SIO, Jaclyn @JMWinterlab, and Alessandra @Eustaq….

Thank you to the American Peptide Society @ampepsoc for highlighting our recent work on graspetides that can be morphed into cyclic peptides: A big shoutout to the lead author on this work @bsmchoi who defended his PhD this week!.

RT @J_A_C_S: Cyclic Peptides from Graspetide Biosynthesis and Native Chemical Ligation | Journal of the American Chemical Society @Princeto….

RT @isciverse: Cyclic Peptides from Graspetide Biosynthesis and Native Chemical Ligation. @J_A_C_S #Chemistry #Chemed #Science #TechnologyN….

Then, we use those thioesters to do native chemical ligation and make some interesting cyclic and branched peptide structures. Congrats to Brian and former Link lab senior thesis student Arthur Acuña ‘23!.

The latest Link lab paper is out @J_A_C_S today led by @bsmchoi: In this work we show that ATP grasp enzymes that usually make esters can also make thioesters.