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New issue! 📣. Read up on antibiotics, moonlighting, arrestin-1, the apoptosome, and more!. Cover art: @BrunerLab and colleagues @UFChemistry @MIT reveal details of the final step of queuosine biosynthesis in modified #tRNA.

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RT @mahas999: Excited to start 2025 with our recently accepted. "Mitochondrial Sorting and Assembly Machinery: Chaperoning a Moonlighting R….

RT @ajlinklab: The latest Link lab paper is out @BiochemistryACS!: This work, led by Angela Zhu, focuses on the cys….

RT @Munelectro: "Metals in Motion: Understanding Labile Metal Pools in Bacteria" @BiochemistryACS This is an insightful review on cellular….

RT @BrunerLab: Happy to have this cover designed by local artist Sammie Bruner associated with our recent publication "Mechanism of Catalys….

Reviews roundup:. In 2024, Biochemistry authors explored GPCRs, antibiotics, and tumor hallmarks, examined PET recycling and telomere motifs, and much more. Catch up with all Reviews here: And find Perspectives here:

New issue! 📣. Read up on biased signaling, RNA editing, gut microbes, antibiotics and more!. Cover art: Lee & Rauscher @UofT explore flexible loops in the main protease of SARS-CoV-2, with implications for drug discovery.

"we propose that TRF2 can be “auto-regulated” through the G-quadruplex formed by its own gene sequence.". Xu and Wang examine a possible feedback mechanism for gene regulation that may extend beyond TRF2/telomeres. #quadruplex.#telomere.#generegulation

Antivirals:. The protein G3BP1 helps to block viral replication, but viruses also have defenses against G3BP1. Dhaka et al @iitroorkee identify new details of this defense and show small molecules that block protein interactions have antiviral efficacy.

Glumatic peptidases play roles in pathogenesis, celiac disease and cancer. Oda @KIT_Kyoto and Wlodawer @theNCI #review the six subfamilies, exploring common features among diverse functions that could drive drug discovery. #tbt.#peptidase.#plant

Inducing expression of cryptic gene clusters can be challenging. Lee et al test two Burkholderia species using high-throughput elicitor screening, finding new molecules with unusual modifications. @PrincetonChem @PrincetonMolBio @PusanUni. #biosynthesis

RT @Diamond_MX: New Paper from I03 in @BiochemistryACS (.

RT @biophyskrys: Our lab's latest paper. This is so exciting!! This paper is literally 10 years in the making, and it is bringing me great….

RT @lipidchronicles: CG17192 is a phospholipase that regulates signalling #lipids in the Drosophila gut upon infection .

Excision repair:. Kirillov et al report the 1.05 Å structure of S. aureus endonuclease IV, revealing Fe atoms instead of Zn & unexpected coordination details. #bioinorganic.@HebrewU @DiamondLightSou @UMich @biocenter @UniofExeter @Hujimed @ENUofficial

⏰ DEADLINE APPROACHING! ⏰ Submit by December 31!. Biased Signaling is an upcoming Special Issue in Biochemistry organized by Executive Editor Bryan Roth (@zenbrainest). Learn more here and get your research seen by the global #Biochemistry community ➡

Finding RNA features:. Rakheja et al report "TRIPinRNA," an in silico platform that searches for triplexes across the transcriptome, and validate several hits, including a structure previously thought to be unstable. #RNA.@IGIBSocial.@AcSIR_India

"These developments provide a promising solution for unlocking the vast knowledge concealed within the protein structure universe and suggest that we have entered a new era of protein structuromics.". Viewpoint by Nie & colleagues @ Jiangnan U. #AI.#tbt

"In this work we investigate the intracellular activation of the dithiolopyrrolones and their resistance mechanisms in bacteria.". From Li and colleagues @uncchemistry. #naturalproducts.#resistance.#prodrug.#redox