Adam Lacy-Hulbert
@adamlacyhulbert
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Immunologist at Benaroya Research Institute and University of Washington
Seattle, WA
Joined May 2016
Today, I am delighted to share @SheenamVerma30’s work, and the ^ first paper ^ from the Harrison Lab @BRISeattle, published in @ImmunityCP - https://t.co/GlgE7XYPwm (1/16)
cell.com
Adaptive immunity to commensal microbes promotes tissue homeostasis, immunity, and repair, but approaches to identify commensal-specific B cell responses are lacking. Verma et al. utilize phage...
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Great paper (and resource!) from my esteemed colleague and fellow @BRIseattle gut immunity program member @harrison_oj. Congratulations to the whole lab and here’s to many more.
Online now: Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers
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And big thank you to everyone at @BRIseattle cores - bioinformatics, flow cytometry, microscopy - for making collaborations like this possible. It is so exciting to work somewhere that fosters immunology research from ctenophores to clinical trials and everything in between.
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Great to have this published and out in the world. Congratulations to @LVandepasii and @cstefani06 on a wonderful collaboration. It has been so much fun to get back into invertebrate immunology and I'm excited to see where this takes us in future work!
So excited to have this awesome collaborative work finally out! Congrats @cstefani06 @adamlacyhulbert! We found that ctenophore (comb jelly) immune cells produce DNA traps as an antimicrobial defense, similar to the behavior of vertebrate neutrophils. 1/ https://t.co/JLZujMQmPC
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Expanding expansion microscopy 🧬 Expansion microscopy is miraculous. Originally invented in the lab of @eboyden3 at MIT, the technique flips the problem of microscopy on its head. Instead of making a more sophisticated microscope, why not make the sample itself bigger? The key
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New in vitro analyses describe how LITAF bolsters cell resiliency to these microbial toxins and to the immune system’s own pore-forming cell death-inducing proteins. @cstefani06 @adamlacyhulbert Read more: https://t.co/klrNdxAye2
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And check out the full version of the paper at @SciImmunology. Thanks to everyone at @BRIseattle and collaborators at @UW_Immunology. https://t.co/psiV7dTpVn
science.org
The endosomal protein LITAF links membrane damage caused by toxins and gasdermin D to ESCRT-mediated repair, promoting cell survival.
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Great to see this new paper from our lab out in the world today. This is a beautiful piece of work from Caroline @cstefani06, using our transposon genetic screen to find a new role for the endosomal protein LITAF in membrane repair. Read her thread for the whole story!
Our paper is out today in @SciImmunology. We set out to understand how cells sense and respond to pore-forming proteins inducing membrane damage. We discovered a new membrane repair pathway that protects against pore-forming protein-induced cell death🧵1/6 https://t.co/KOu029pw3S
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Alina has done beautiful work on the role of alpha v beta 3 integrins in regulating TLR signaling in plasmacytoid DCs and autoimmune disease. Paper coming soon, watch this space...
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Congratulations (slightly belated) to Dr @LorantAlina who successfully defended her thesis this week. It has been a joy to have her in the lab and a privilege to watch her grow into such an accomplished scientist!
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We are thrilled to share that Dr. Lynda Stuart has joined as our new Executive Director. With her extensive experience and dedication to healthcare as a human right, the future of protein design looks brighter than ever. Learn more: https://t.co/vM3K0rOQhC
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Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine, vaccines & advanced materials, free to use. The software has proven much faster and more capable than prior protein design tools. https://t.co/lhkhBZNzYc
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BRI’s two-year postbaccalaureate program allows recent college graduates to engage in #Research at the forefront of immunologic, allergic and infectious diseases under the guidance of a BRI PI. Applications must be submitted by March 1, 2023. Learn more: https://t.co/qPMMni9JBX
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🥳👏Congratulations @KedmiRanit and Dan Littman’s lab @nyulangone. Glad I could make a small contribution to this beautiful work @Nature Want to learn more about iTreg cell differentiation program? 🧵👇 on the contribution of ROR𝛄t+ APCs via ⍺vβ8-mediated activation of TGFβ
Thrilled to share my research from Dan Littman's lab at @nyulangone, online today in @Nature. If you are interested in the differentiation of CD4 T cell programs and the mucosal iTreg response, this is for you. #Treg, #ILC3, #Tolerance, https://t.co/sGbuEgXNyf, A 🧵 /1
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Dear grad school applicants, despite the power imbalance of grad school interviews, almost all the faculty who you will meet are just as excited about meeting you! Be curious! Be excited! Most of all, be yourself! That’s what got you the interview! Good luck!
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Proud to work with Lynda - truly an unsung hero over this past year! If you want to hear more, tune in to her TED talk, live streaming Saturday.
tedxseattle.com
Meet Lynda Stuart: Deputy Director at the Gates Foundation, a doctor, and a passionate advocate for healthcare as a human […]
We are so proud to have Lynda Stuart, MD, PhD, on the BRI team! In addition to being an Affiliate Investigator at BRI, Dr. Stuart is Deputy Director of Vaccines & Human Immunology at @gatesfoundation. Learn more: https://t.co/ifBogPljoR
#UnsungHeroesImmuno #BlackinImmunoWeek2021
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Important thread.
Seven years ago today I walked out of the hospital after surviving Ebola. That day at a news conference—my knees shaking—I begged the world to focus on the still-raging outbreak in West Africa. Instead, when the immediate threat was over, we moved on. Years later, Covid hit 🧵
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Impressive molecular sleuthing! This is why I am on SciTwitter…
I looked at 15,911 luciferase sequences in GenBank. Five contain the peptide 'DEVIL' but not a single one has 'FREEDOM'.
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