If women gave up every time we got evidence people hate us or don't even consider us people, nothing would ever get done. So take a minute, "honor" the reality of the awful feelings, but then we're back to our regularly scheduled program of building the least-worst world we can.

🎉#JI_TopRead ➡️ This study by @LorantAlina et al. @cstefani06 @adamlacyhulbert @BRIseattle investigates the role of integrins in the regulation of responses by plasmacytoid DCs. Check it out now! #ReadTheJI #immunology https://t.co/csw6Di08yb

Calling all immunology research professionals! Join us at our first annual immunology symposium, “New Horizons in Immunity and Disease,” on Wednesday, May 22, at @THSEA. RSVP today: https://t.co/6gfZ656pi5

It was surreal! From the backyard in the middle of west Seattle. #Auroraborealis @westseattleblog

Today, I am delighted to share @SheenamVerma30’s work, and the ^ first paper ^ from the Harrison Lab @BRISeattle, published in @ImmunityCP - https://t.co/GlgE7XYPwm (1/16)

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnels by stiffening the plasma membrane. https://t.co/pYwtbDnxa1

So excited to have this awesome collaborative work finally out! Congrats @cstefani06 @adamlacyhulbert! We found that ctenophore (comb jelly) immune cells produce DNA traps as an antimicrobial defense, similar to the behavior of vertebrate neutrophils. 1/ https://t.co/JLZujMQmPC

French legislators on Monday voted to explicitly enshrine access to abortion in the Constitution, making their country the first in the world to do so. https://t.co/EqAiNSa5tF

In @elife: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

This week, we profile Drs. Adam Lacy-Hulbert (@adamlacyhulbert) and Caroline Stefani (@cstefani06) from @BRIseattle. They expand on their @SciImmunology publication and how their approaches uncovered the mechanisms behind membrane repair machinery. Read: https://t.co/Dlor22ugR2

When you think you finally found a city where you can feel safe ... The fight never ends. https://t.co/AYyXayOsSg

Expanding expansion microscopy 🧬 Expansion microscopy is miraculous. Originally invented in the lab of @eboyden3 at MIT, the technique flips the problem of microscopy on its head. Instead of making a more sophisticated microscope, why not make the sample itself bigger? The key

New in vitro analyses describe how LITAF bolsters cell resiliency to these microbial toxins and to the immune system’s own pore-forming cell death-inducing proteins. @cstefani06 @adamlacyhulbert Read more: https://t.co/klrNdxAye2

The first Science #Immunology issue of the year is here! The January cover depicts research on gut immune cell migration. Other studies spotlight the LITAF protein and the relationship between regulatory T cells and hair follicle stem cells. https://t.co/FPpDssNOFZ

@mcsinton focuses on the necessity for #LGBTQSTEM people working in academia to feel safe, without fear of repercussions for revealing or expressing their identity: https://t.co/RtEGt6YQp2

In a recent publication in @SciImmunology, a research team from BRI + @UW have identified a gene that can help boost cell repair and limit cell death — a finding that could lead to new therapeutic approaches to limit progression of immune system diseases: https://t.co/W0Z4QK2zRf

Huge thanks to everybody involved in this study: @BRIseattle @AnnaBruchez @mgrosasco @AndrewOberst @pNW_Hubbard @LorantAlina @adamlacyhulbert as well as Kayla Fasano, Anna Yoshida and Lynda Stuart. 🧵6/6

LITAF-mediated repair occurs at endosomal membranes, resulting in the expulsion of damaged membranes as exosomes, rather than through direct excision of pores from the surface plasma membrane. 🧵 5/6

We demonstrated that the activation of the ubiquitin ligase NEDD4 by potassium efflux mobilizes LITAF to recruit the endosomal sorting complexes required for transport (ESCRT) machinery to repair damaged membrane. 🧵 4/6

We show that LITAF is necessary and sufficient to promote a new mechanism of repair, through late endosome/MVB relocalization of the pores, including alpha-toxin, streptolysin O and the endogenous pore GasderminD. 🧵 3/6