aleksei mikhalchenko
@a1eksei_m
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#reproductivegenomics #gametebiology @OHSUNews; prev: #aging @HarvardMed @BrighamResearch all things genomics and transgenerational genome inheritance
Portland, OR
Joined May 2017
Could be even more efficient and cost-effective to cure/eliminate these genetic conditions during the pre-implantation phase.
The recent FDA's Cell and Gene Therapy Roundtable - hosted by FDA commissioner @MartyMakary and the director of the FDA’s Center for Biologics Evaluation and Research (CBER) @VPrasadMDMPH, was a highly important event which will not only shape the future of the American BioTech
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30 Essays to Make You Love Biology Day 1. "I should have loved biology" by James Somers. "It was only in college, when I read Douglas Hofstadter’s Gödel, Escher, Bach, that I came to understand cells as recursively self-modifying programs."
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Complete sequencing of ape genomes https://t.co/y80nk5iqLX
#biorxiv_genomic
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My favorite T2T/Pangenome discovery so far: a multi-megabase inverted segmental duplication on the short arm of chr14 that explains the mechanism of Robertsonian translocations. Great writeup by @ScienceStowers "Answering a 50-year-old mystery" https://t.co/u90TGUwnYt
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Big news: the "3-parent baby" tech is meant to prevent disease in babies. But new evidence suggests that it might not work in around 1 in 5 cases. Some scientists believe there's a 20% risk of potentially creating a baby with disease. https://t.co/ftJ6EkG6Ge
technologyreview.com
The approach was designed to prevent mitochondrial disease, but new evidence shows it might not work as planned.
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In the latest issue! A transcription factor atlas of directed differentiation
cell.com
Generation of a comprehensive human transcription factor (TF) barcoded ORF library and further application to embryonic stem cells to build a TF Atlas of resulting expression profiles, which enabled...
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1/ There are too many unanswered questions about women’s reproductive health. ❓Why does menopause occur? ❓What causes endometriosis and can we cure it? ❓What’s the impact of oral contraceptives on mental health? To help find answers @fiftyyears is launching @reprogrants!
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Check out the special issue on human embryo development that @nmoris and myself put together. Really great reviews! Thanks a lot to all the authors that contributed.
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A summary of current views on epigenetic clocks and rejuvenation. #longevity #aging
https://t.co/SgtxYsdMTe
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The HFEA is considering changes, including to the Day 14 rule, to make it “future proof”. More from my @TheCrick colleague Robin Lovell-Badge here: https://t.co/hNmmAh11Qz
theguardian.com
Exclusive: HFEA discussing how to ‘future-proof’ legislation to keep pace with scientific advances
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Research labs are unable to recruit postdocs. I think alternative options became just so much more attractive. https://t.co/yBU0PooehV
nature.com
Nature - Even high-profile scientists are struggling to recruit qualified postdoctoral researchers.
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Really pleased this is now online: Inside the race to make human sex cells in the lab
technologyreview.com
Scientists might soon be able to create eggs and sperm from skin and blood cells. What will that mean?
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We are looking for a senior manager to help lead the Biomedical Data Science Initiative at the U. of U Health Sciences campus. Please share! https://t.co/0IhG0iKNN3
jobrxiv.org
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
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Variable RNA sampling biases mediate concordance of single-cell and nucleus sequencing across cell types https://t.co/2lv1i58Q4y
#biorxiv_bioinfo
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Our crazy journey on this continues - New Hanna lab @CellCellPress paper is out: "Post-Gastrulation Synthetic Embryos Generated Ex Utero Solely from Mouse Naïve ESCs" by the amazing @TaraziShadi @AlejandroAgCa @carinejoubran @noashefi & @MazaItay
https://t.co/UNWW3zEfNr
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The International Symposium “Totipotency and Germ Cell Development”
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Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys https://t.co/heW1tEYBEn
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#Bionano announces a new publication using #OGM to investigate chromosome instability during culture of iPSCs. The paper outlines support for use of OGM in regenerative medicine which could have utility for pharma research and drug development. Read more: https://t.co/D1XzwFL2Hu
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