‼️New preprint‼️ Super excited to share this work by the incredible @anlijuncn. We explore the potential of plasma proteomics and AI for neurodegenerative disease (AD, PD, ALS, FTD,CVD) diagnosis in a massive dataset (N>17,000). Paper link and walkthrough in Lijun's 🧵 below!

Ten years (!) after submitting the grant, NextBrain is published in @Nature . NextBrain is a brain atlas built from 3D histology that enables segmentation of 3D brain scans (MRI, Hip-CT, even photos!) into hundreds of regions. Article, data, code, videos, & more in this 🧵 (1/3)

This went around a year ago or so. But this is how to make mandates conflict of interest statements trivial for many people.

Delighted to share that the preprint is now published: https://t.co/8eVjcUit7G @ChenZhang_NUS @anlijuncn @kimnganngt @AgingMacc @HelenJuanZhou @csabaorban

🧠✨ Genetic Tools Atlas 3.0 is here! The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets. 🔗 https://t.co/nYJdW24A7w

I have re-released my most used script to facilitate widespread use. antsRegistration_affine_SyN.sh is a replacement for the basic script provided with ANTs. It provides a more sensible set of defaults, and more expansive options. https://t.co/SEvpPCusAo

Has your research funding been cut by the administration? NYT wants to hear from you. We need to be loud now, not quiet, about these things. The attacks on science have to stop. Spread widely. https://t.co/1lQ6AThHQa

Really compelling evidence in humans for network propagation hypothesis of tau spread: individualized connectivity helps resolve individualized tau patterns

🚨New publication in Brain Communications! In this study, we show that microglial cells play a key role in Alzheimer's disease, particularly in regulating changes in soluble tau, based on cell-type-specific genetic evidence. 🔗Full paper:

Nominations are open! Honor outstanding mentors with the Excellence in Neuroscience Mentoring Award or recognize early career trailblazers at AAIC Neuroscience Next. Submit by Oct. 31: https://t.co/KBIDjzqLCX

(1/3) We are releasing SuperSynth, a neural network for simultaneous segmentation, T1/T2/FLAIR synthesis+super resolution, and atlas registration of any brain MRI scan (including low-field, ex vivo, single hemispheres). You can find it in @FreeSurferMRI : https://t.co/rwfwvzcJx3

In our new paper, we show that neuroinflammation in Alzheimer’s follows a two-wave pattern of harmful effects: 1️⃣ First wave: triggered by amyloid-β (Aβ) 2️⃣ Second wave: driven by widespread tau pathology 📄

This is a major milestone for @sylv_villeneuve & PREVENT-AD. Their vision & dedication have led to a series of impactful studies & high-profile publications, and the future promises insights as this unique dataset continues to grow. https://t.co/rRD8lg21A6

Check out our data! Please reach out if you're interested, we're happy to provide more info and we may have useful datasets (e.g., with extra cleaning or composite variables) to address specific questions. Raw and derived MRI data also available upon request for ~1/2 the cohort.

Genotype-phenotype data from over 450,000 individuals was analysed to discover 205 genomic loci where an allele associated with increased adiposity was associated with a lower cardiometabolic disease risk to an individual

🚨New publication in Nature Medicine! In this study, we demonstrate that a brief, self-administered cognitive test battery can reliably identify individuals with cognitive impairment in a primary care setting. Details: https://t.co/tSwVYOlzWS Full paper:

We have multiple openings for PhD candidates and postdoc positions: https://t.co/NiNK3LxvBD!

The effect of spherical projections on spin tests for brain maps | https://t.co/NAkXjsO9Jo Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @VinceBazz explores ⤵️

I’m running to become the 1st person from Morocco to go to Space–together with @seraspaceage and @blueorigin 🚀🇲🇦🌍 Support my journey! Create your own SERA Space profile on Telegram thru my referral link here: https://t.co/pBPR6JezLK #SERAspace

We are excited to launch The Data Quartet Challenge, recognizing student contributions to projects that integrate data from at least 2 of 4 FRQ supported Quebec Alzheimer’s and Aging cohorts (PREVENT-AD, CIMA-Q, NuAge, TRIAD), with 3 prizes of 5000$ https://t.co/jUYizVxi2u

In our new study @NatureComms, Dr Soares et al show that CSF total tau, often used as a marker of neurodegeneration, is more strongly linked to synaptic degeneration than axonal or neuronal loss in Alzheimer’s disease. Check our paper here🔗 https://t.co/AP74CkgmsX