SaraH Zanders 🎃💀
@ZandersLab
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I use fission yeast to study selfish genes during meiosis to learn more about possible causes of infertility. Opinions are mine not my employer’s
Kansas City, MO
Joined September 2016
Thrilled to announce - our latest on polyploid arenosa just got published in Science :-) Thanks to the amazing team that made it happen including @Thsrikant and @AdriGonzalo!! And thanks reviewers for enthusiasm, especially reviewer 1, whoever you are! https://t.co/YgT0c7CL3C
science.org
Mechanistic follow-up to a genome scan shows selection targeted pollen tube tip growth to rectify neopolyploid fertility defects.
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Really excited about our latest preprint on dominance of nonsynonymous deleterious mutations in humans. Chris's thread provides an excellent summary of the work!
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Preprint🚨on a new mechanism of genetic cheating in meiosis! 🧬We found that a mouse selfish DNA, R2d2, combines the elements of both male and female meiotic drivers! (gamete sabotaging in female meiosis) https://t.co/C6nZQr9kvI
biorxiv.org
During meiosis, homologous chromosomes segregate so that alleles are transmitted equally to haploid gametes, following Mendel’s Law of Segregation. However, some selfish genetic elements drive in...
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How does Pombase use resources effectively? With a little help from our friends...@rcsbPDB @news4go @rhea_db @MonarchInit @alliancegenome @usejbrowse @yeastgenome @uniprot @InterProDB @Micropub7n Thread/
academic.oup.com
Abstract. PomBase (https://www.pombase.org), the model organism database (MOD) for fission yeast, was recently awarded Global Core Biodata Resource (GCBR)
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In wild fission yeast, love finds a way on Valentine's Day ❤️
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Preprint alert! 🐜 🧬 The first from my PhD with @DanielKronauer, with an assist from @teraxurato. We discovered an unusual case of “unselfish” meiotic drive while studying asexual reproduction and its genomic consequences in the clonal raider ant.
biorxiv.org
According to Mendel’s second law, chromosomes segregate randomly in meiosis. Non-random segregation is primarily known for cases of selfish meiotic drive in females, in which particular alleles bias...
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I had a lot of fun working on this story and I'm pleased to see it now published. A pleasure as always to work with @TheRogLab and congrats to undergrad Jesus on his first publication 🎉 See quoted tweet for a link to the paper and a taste of our findings 🙂
Proud to have out this paper at @PNASNews from @LisaKursel and Jesus on the synaptonemal complex in C. elegans. It includes what is probably the most beautiful genetic data I was ever involved in analyzing - check it out!
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Be sure to check out this new publication in @PLOSBiology describing an interesting link between cell-type specific regulation and carbon metabolism led by PhD student John Crandall (@uwgenetics) https://t.co/MGGkmQOzCf
journals.plos.org
Ploidy is a fundamental trait of all organisms, but it varies within and between fungal species. This study reveals how strong conditional selection on a metabolic trait can lead to ploidy and cell...
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Excited to see our latest collaboration with @DrinnenbergLab and @leonidmirny lab looking at interphase genome organization in Bombyx online now!
Freshly posted on bioRxiv, our @ScienceLeah collaborative work with the Drinnenberg and Mirny labs characterizes unique compartment S (Secluded) in the holocentric silkworm moth
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Proximity labeling reveals new insights into the relationships between meiotic recombination proteins in S. cerevisiae
biorxiv.org
Several protein ensembles facilitate MutSγ crossover recombination and the associated process of synaptonemal complex (SC) assembly during meiosis, but the physical and functional relationships...
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Great work from postdocs Xin Zhou and Petra Vande Zande in our group! The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number https://t.co/q9cGN3MwTV
annualreviews.org
Fungal species have dynamic genomes and often exhibit genomic plasticity in response to stress. This genome plasticity often comes with phenotypic consequences that affect fitness and resistance to...
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Applications are now open for @stowersgrad #PhD in #Biology program! If you are looking for mentorship, incredible labs, and a collaborative environment then explore our program further. Applications due December 1: https://t.co/Q6ZZjg3E3d
#GradStudent #GradSchool
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Twitter may be dying, but the Starr lab is coming to life! We put out the first preprint from the lab @UofUBiochem, where we performed deep mutational scans on the SARS-CoV-2 BQ.1.1 and XBB.1.5 variant RBDs 🧵
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The Özel Lab at Stowers Institute is hiring at all levels! We are looking for motivated postdocs, technicians as well as a lab manager and a bioinformatician. Application info:
stowers.org
This is where you can thrive with the support of dedicated and talented colleagues, unmatched resources, and continuous opportunities for learning.
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Looks like an amazing new paper, from some of my favorite people (@greggwcthomas, @levine_lab, @jeffreymgood). https://t.co/UBPjOpYns0
biorxiv.org
A species tree is a central concept in evolutionary biology whereby a single branching phylogeny reflects relationships among species. However, the phylogenies of different genomic regions often...
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A fantastic #WednesdayLectureSeries, on a Tuesday! Thank you to @tylernstarr, from @UofUBiochem, for joining us for a presentation titled "Molecular evolution of SARS-CoV-2 and related bat coronaviruses". Hosted by @StowersGrad!
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Very happy to finally be able to share our work at @NAR_Open! We aimed to answer the question: why does the well-known transcriptional activator Swi-Snf seem to repress genes involved in metabolism? Thanks to @jerryleeworkman and all at @ScienceStowers
https://t.co/I4GFc6kqoW
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Today the Nelson Lab opens at @stonybrooku! I'm very excited to start this adventure and looking forward to building an amazing team. Learn more about the lab and opportunities to join at https://t.co/dRfKrNUYrV.
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