Zhao-Xun Liang
@ZX_Liang
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Nanyang Technological University, School of Biological Sciences, Singapore
Singapore
Joined November 2017
Functional Characterization of a Diazo-Forming Enzyme in Meroterpenoid Biosynthesis.
chemistry-europe.onlinelibrary.wiley.com
A diazo-forming enzyme (stFur5) facilitates deamination in the biosynthesis of furaquinocins and other polyketide-derived meroterpenoids.
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Big Thanks to our collaborators @pchaiyen @guanglei_Ma @HoaUSD12345, Profs Li Jian, and Gao YG. An Enzymatic Oxidation Cascade Converts δ-Thiolactone Anthracene to Anthraquinone in the Biosynthesis of Anthraquinone-Fused Enediynes | JACS Au
pubs.acs.org
Anthraquinone-fused enediynes are anticancer natural products featuring a DNA-intercalating anthraquinone moiety. Despite recent insights into anthraquinone-fused enediyne (AQE) biosynthesis, the...
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Streptomyces sungeiensis SD3 as a Microbial Chassis for the Heterologous Production of Secondary Metabolites | ACS Synthetic Biology A useful Streptomyces strain from the Johor Strait @zjlow @guanglei_Ma @.
pubs.acs.org
We present the newly isolated Streptomyces sungeiensis SD3 strain as a promising microbial chassis for heterologous production of secondary metabolites. S. sungeiensis SD3 exhibits several advantag...
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RT @biorxiv_micrbio: Bacterial cGAS-like enzymes produce 2',3'-cGAMP to activate an ion channel that restricts phage replication https://t….
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RT @TurnerLabUQ: Happy to share our review of cyclic-di-AMP signalling in lactic acid bacteria as part of the @LABsymposiumorg .special edi….
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RT @Dr_Lori_Burrows: “resistant #pseudomonas was especially difficult to eradicate” 😱
nytimes.com
The C.D.C. traced deaths and cases of blindness to products imported from India. The agency said it was concerned that the bacteria could gain a foothold in the U.S.
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RT @UWproteindesign: Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine….
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Enaminone formation drives the coupling of biosynthetic pathways to generate cyclic lipopeptides @hart.
chemistry-europe.onlinelibrary.wiley.com
A group of enaminone-containing cyclic lipopeptides were surprisingly found to be formed in microbial cells. The enaminone moiety results from the coupling of two biosynthetic pathways via amine-al...
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RT @EnzymeChemistry: #Biosynthesis of Tasikamides via Pathway Coupling & Diazonium-Mediated Hydrazone Formation by @guanglei_Ma, H. Candra,….
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To our surprise, we found hydrazone can be formed via diazonium-mediated Japp-Klingemann reaction in microbial cells, thanks to the excellent work of @guanglei_Ma, Hart, @hoatran227, @zjlow, Pang LM. and our collaborators Profs Cao Bin and Fang Mingliang.
Online NOW | @J_A_C_S . #Biosynthesis of #Tasikamides via Pathway Coupling and Diazonium-Mediated #Hydrazone Formation. @isciverse @AmerChemSociety .
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RT @mitchguttman: What drives organization of RNA, DNA, and proteins in the nucleus? In our new paper out @CellCellPress, we show that non-….
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RT @GordanLauc: Understanding biology, and host/pathogen interactions in particular (including #SARSCoV2) without looking at glycan part of….
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RT @uniprot: A historic moment in the world of molecular structural research. #AlphaFold structure predictions for 22 species made freely a….
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RT @ntusbs: Very pleased to see that we are ranked 3⃣3⃣ in the world in Biological Sciences by QS @worlduniranking. Awesome work from #ntus….
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Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes @hoatran227 @zjlow.
pubs.acs.org
Anthraquinone-fused enediynes (AQEs) are renowned for their distinctive molecular architecture, reactive enediyne warhead, and potent anticancer activity. Although the first members of AQEs, i.e.,...
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RT @mbiojournal: A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation http….
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RT @TurnerLabUQ: Pleased to share our latest work on c-di-AMP with great collaborators @Es_Marcellin and @ZX_Liang .Cyclic di-AMP Oversight….
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Identification of signaling pathways, matrix-digestion enzymes, and motility components controlling Vibrio cholerae biofilm dispersal
pnas.org
Bacteria alternate between being free-swimming and existing as members of sessile multicellular communities called biofilms. The biofilm lifecycle ...
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