Richard Lewis
@Z3R0Gravitas
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Extropian sci/tech geek. Improving moderate #MEcfs, #non24-hour sleep. #ADHD-PI, #AuDHD, #dyslexic. "ZeroGravitas" in PC gaming. He/him. 42. Please correct me.
UK
Joined March 2009
I've been trying for 2 years to get this finished! https://t.co/D2OHM0l3dL An index of my biggest, best & more interesting Twitter threads and forum posts on #MEcfs & related topics. Spanning 9 years of my time in this community. 💙 1/n
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Please reply to the photo posts rather than the tag tweets.🙏 Like THIS tweet to join the above list of tags and be sure not to miss future posts. DM, reply or message me by carrier pigeon "unsubscribe" to leave at any time, no questions asked. 💙🙂
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2/ - These seed heads also ID'd as "Field Sowthistles", same spot beside our driveway, but a couple weeks earlier than above... - Waist high, there too, Gemini thinks "Pearly Everlasting" (Anaphalis triplinervis), but I don't trust it. It's been even more haphazard lately.
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1/ #WeedsWednesday - PlantNet says not mere "dandelions"?!: - "Field Sowthistle"? With Common drone fly, exceeding it's name in appearance. - "Weedy Hawksbeard" (Crepis vesicaria), I thought a mutant dandelion! - Autumnal Hawkbit. #MEcfsEgress #BloomScrolling DailyNaturePics 168
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8/ 2023 thread about NMDA and AMPA receptor function (and biohacking):
The NMDA receptor is one of 2 main kinds of receptors activated by Glutamate (AMPA receptor being the other) Weak electrical stimulation of the presynaptic neuron causes the release of glutamate from the axon terminal. This glutamate binds to both AMPA and NMDA receptors.
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7/ Nice graphic from press release (short thread):
From press release of Japanese study: "Molecular brain imaging as a tool for understanding Long COVID: These brain images show how increased levels of AMPA receptors correlate with both cognitive dysfunctions and inflammatory biomarkers" #LongCovid #NeuroPASC 1/
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6/ Post on using L-Theanine:
L-Theanine therapeutic for anxiety, depression, ADHD, OCD. The amino acid found in green tea exerts broadly protective effects in the brain: • Pro-dopamine - motivation • GABAnergic - relaxation • Increases BDNF - brain cell growth + differentiation • NMDA/AMPA antagonist -
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5/ More detailed thread: https://t.co/oybyaLI25k - Japanese group developed AMPA binding tracer. - Density correlated vs cognitive impairment. - Higher inflammatory cytokine TNFSF12, lower CCL2, 100% sensitive, 91% specific. - Propose Perampanel (severe psychiatric risks).
1) 🇯🇵 Japanese researchers found that Long Covid patients have more glutamate AMPA receptors in the brain than controls using PET scans. This difference correlated with results of cognitive tests and various cytokines.
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Please reply to the photo posts rather than the tag tweets. 🙏 Like THIS tweet to join the above list of tags and be sure not to miss future posts. DM, reply or message me by carrier pigeon "unsubscribe" to leave at any time, no questions asked. 💙 🙂
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Nature pic notification crew: @IsabelRamirezRD @cfs_jo @Naomi_D_Harvey @elle_carnitine @CiaraGlenville @_Joannesmith @jubbleso @Riemerville @subversivepsych @TaraFotiPhD @SergiCathy @elljuna @hiimchiralkthx @rhymeswithvery @Annakwood @Knitty19 @irishiker @aTiredOwl @Bettje37 ...
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3/ Winding back to 1980 (before I was born) and 1987, respectively. Dad's photos (Pentax camera with a Sigma Lens, possibly). Only righty remains, flagging a bit, lefty chopped having taken up too much space together.
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2/ Late May gusts, animating the foliage like I was pointing a giant leaf blower at them. - The Birch is next door's (tall one on the right). - The ever green, in the middle, is one of 2 that grew up with me...
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1/ #TreeTuesday - one of my great fortunes has been a garden surrounded by beautiful trees. Vid below. SLR shots: - White Cedar, Arbor-vitae or Lawson Cypress(..?) evergreen (wallpaper worthy gradient). - Common white (or silver?) Birch. #MEcfsEgress DailyNaturePics 167
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3/ Hip_III (PhoenixRising superstar poster) on Reddit: https://t.co/IxuxKoWRkZ ... Links a list of AMPA inhibitors, with an anecdote that high dose L-Theanine helped one patient. Also commenting that TNFa is known to upreg APMA.
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2/ There's some skepticism about likely bias in the study:
The lead author of this study owns the patent on this specific tracer. They only looked for their specific receptors (glutamate subtype) without checking alternatives/the rest of the excitatory/inhibitory system This is confirmation bias + conflict of interest
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1/ AMPA receptor upregulation in Long Covid study, claiming possible explanation for brain fog. Compiling various takes (to maybe dig into some time)...
Wow. This new study ties together glutamate and cognitive long covid @KatBoniface The researchers "demonstrated that increased index of AMPAR density in large parts of the brains of patients with Cog-LC compared with that in healthy controls" Systemic increase of AMPA receptors
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Outlook was from the path just to the left of where this tractor was spraying (presumably weed killer, or fertiliser?) the other day. So perhaps not ideal.
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