Debbie @ Genetic Lifehacks
@GeneticLifehack
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Understand your DNA. Optimize health, diet, & longevity with Genetic Lifehacks. #Biohacking
Small town, MT
Joined February 2015
1/ Did you know that you can use your genetic raw data file from #23andMe or #AncestryDNA to learn more about your health? A thread on using your data to optimize health and prevent chronic disease đ§”
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The mystery of why naked mole rats live so long may have been solved. Naked mole rats can live up to 37 years, while their normal-looking rat counterparts average just a few years. Researchers found that cGAS, an enzyme that detects DNA damage, is altered in naked mole rats. The
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At the University of Göttingen, researchers studied blood from people with ALS and found autoimmune CD4+ T cells that target the C9orf72 protein. These cells produced IL-4, IL-5, and IL-10, linking ALS to an autoimmune response for the first time. https://t.co/Ox3SCmMaoK
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Restoring mitochondrial health in the brain may help with anxiety. (And depression, etc) A new study used urolithin A in animals bred to have heightened anxiety. Urolithin A added to their food reversed the nervous behavior in the animals with a genetic propensity towards stress
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OUR NEW LAB PAPER IS OUT showing that Urolithin A reverses high anxiety by repairing mitochondria in nucleus accumbens Big kudos to first co-authors David Mallet & DoÄukan Ălgen, our amazing team, and collaborators @MitoPsychoBio @Amazentis1 Paper: https://t.co/BKp0Cvyyyr...
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Wow. This new study ties together glutamate and cognitive long covid @KatBoniface The researchers "demonstrated that increased index of AMPAR density in large parts of the brains of patients with Cog-LC compared with that in healthy controls" Systemic increase of AMPA receptors
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Did you know trace minerals like zinc, selenium, & manganese can supercharge your brain? đ§ This article dives into how these nutrients optimize neurocognitive function, boost memory, & support mental clarity -- figure out how to personalize your brain and nutrition based on
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Thereâs a new study out in Nature about how mitochondria are contributing to senescence and thus chronic inflammation in aging. The researchers from the Max Planck Institute for Biology of Aging have found that, as we age, mitochondrial DNA ends up incorporating RNA building
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Green light exposure reduces stereotypical uncooperative behaviors among autistic children during dental procedures. @NicoleRinconPA
https://t.co/8cP7Cw1Rp1
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âïž Is coffee the secret to brain healthâor just a trending headline? Recent studies show drinking 3+ cups/day could cut Alzheimerâs risk by up to 40%! But your genetics matter: slow caffeine metabolizers may actually get the biggest dementia protection. Learn which genes impact
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This is interesting and raises a bunch of questions on how changes to the gut microbiome (eg from sucralose) impacts the bodyâs immune response. Sucralose Associated With Weaker Responses to Immunotherapy
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đ„ The NLRP3 inflammasome: your bodyâs danger sensor for pathogens & cell damage. Overactive? it drives chronic inflammation tied to Alzheimerâs, gout, type 2 diabetes, and more. Genetic variants in NLRP3 can amplify inflammatory responses, but nutrients like zinc & vitamin D
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This is super interesting. When I was writing this article a few years ago on genetic variants that impact BH4, I kept thinking it likely interacted with long Covid. https://t.co/kyh2psZ6YY
geneticlifehacks.com
Tetrahydrobiopterin (BH4) is an essential cofactor in the production of neurotransmitters and nitric oxide. Genetic variants impact BH4 level.
Super interesting finding. BH2 & BH4 both reduced during PEM for ME/LC patient. As a disease no major difference were seen against control, but this PEM finding could indicate a wider PEM specific mechanism that isnât seen during rest.
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A new study in primates seems to have moved the needle on aging and healthspan. Researchers used FOXO3-enhanced mesenchymal stem cells intravenously for 44 weeks (biweekly) in monkeys. They were able to reverse the biological age of most organs by 3-5 years (corresponding to
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Did you know your genes could be affecting your body's master antioxidant, glutathione? Low levels from variants in GCL/GSR genes mean poorer detox of mercury & toxinsâboost with NAC! https://t.co/FZo493noL8
#Genetics #biohacking
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When a giant like Walmart does this, itâs more than a nod. Good work team!!!
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You can check your genes here to see if you are likely to have a fast or slow CYP1A2-related caffeine metabolism as well as the metabolism of melatonin and a few other medications.
geneticlifehacks.com
The CYP1A2 gene breaks down caffeine and medications. Check your genetic data to see if you are a fast or slow metabolizer of caffeine.
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Do you ever feel groggy after taking melatonin? It turns out that the CYP1A2 enzyme metabolizes melatonin. This is the same enzyme that metabolizes caffeine. And there are somewhat common genetic variants in CYP1A2 that slow down its function -- slower breakdown of
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Exciting new paper @nature that could explain why inflammation rises as we age and why healthy diets and exercise suppress inflammation đ đ§”
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