1/Excited to share our latest study showing that RNA sequestration in P-bodies sustains myeloid leukemia - now out in @NatureCellBio! 🧵 below:.

Excited to join the Stem Cell Reports team as an Early Career Editor!.Grateful for the opportunity to support the stem cell community and contribute to the journal alongside a fantastic group of colleagues. @ISSCR @stemcellreports

RT @stemcellreports: The ISSCR has selected five distinguished early career scientists to serve as new Early Career Editors for Stem Cell R….

RT @leo_jwu: Excited to share our new study in Cell—congrats to Daniel, co-authors, and our collaborators in the @PeterLyLab What began as….

RT @stemcellreports: Hear from Stem Cell Reports Editor-in-Chief Janet Rossant and Associate Editor Martin Pera about the countless opportu….

RT @biorxiv_cellbio: Selective RNA sequestration in biomolecular condensates directs cell fate transitions #biorxiv….

RT @ShorterLab: Selective RNA sequestration in biomolecular condensates directs cell fate transitions:

New preprint from the lab! With @Brumbaugh_JB, we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming.

RT @qichen_lab: We put together a step-by-step protocols for PANDORA-seq, now available in @NatureProtocols, including the sample preparat….

RT @jyoti_nangalia: How blood ages - A curious case of mice and men. Our latest study @Nature published today. Biological processes such….

RT @embojournal: Synergistic & antagonistic activities of IRF8 & FOS enhancer pairs during an immune-cell fate switch.Graf, Nikolaou et al….

RT @naxerova: Cancer evolution enthusiasts - you might be interested in some new data from our lab on quantifying cell divisions along evol….

RT @NatRevImmunol: Biomolecular condensates in immune cell fate

5/ Recent technological advancements have powered these studies, enabling answers to previously unanswerable questions (Fig. 4). Despite this progress, critical evaluation of the evidence concerning condensate properties is essential to understand their role in immune cell fate.

4/ Conversely, dysregulation of condensates has been linked to deleterious immune cell fates, including impaired function, autoimmunity, aging, and malignant transformation (Fig. 3).

3/ Recent studies have implicated condensates in the transcriptional and post-transcriptional processes that drive proper immune cell fates, from the level of hematopoietic stem cells to innate and adaptive immune cells (Fig. 2).

2/ Condensates are diverse, membraneless assemblies of nucleic acids and proteins (Fig. 1). They are thought to enable temporally precise control of gene expression by concentrating or segregating components of the gene regulatory machinery and their targets.

1/ Pleased to share our review, published today @NatRevImmunol, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development.

RT @josh_brickman: In the next few weeks we will start advertising for PhD students and/or post docs. We are looking for two people to joi….

RT @Brumbaugh_JB: Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: https://….

RT @efapostolou29: Excited to share this collaborative work with @Hadhjantonakis and @dana_peer led by @Vid_ur reporting drastically diffe….