1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 https://t.co/D7fnkJgNQ6

This is one of the most interesting papers that I have ever read!

8/ Huge thanks to our editor and reviewers for invaluable feedback, and to our funders NIGMS, @theNCI, @NIAIDNews, @ASH_Hematology, @WorldwideCancer, @BePositiveFdn, @WebbWaringAwrds, NICHD, and @CPRITTexas for supporting this work!

7/ Our findings establish a fundamental, conserved role for P-bodies in cell fate specification and reveal novel strategies to manipulate RNA condensates for directing cell identity in regenerative medicine.

6/ Applying these insights to stem cell differentiation, we show that manipulating P-body assembly or specific microRNA activity can direct pluripotent stem cells toward totipotency or the germ-cell lineage.

5/ What drives the selective sequestration of mRNAs in P-bodies? We found that certain cell-type–specific microRNAs are enriched in P-bodies and modulate RNA sequestration. Disrupting microRNA–target interactions prevents the corresponding mRNAs from being sequestered.

4/ Dissolving P-bodies in mouse naïve ESCs increased ribosome occupancy of P-body–enriched RNAs, including 2C transcripts, triggering reversion to a 2C-like state. This shows that releasing RNAs from P-bodies enables their translation and drives cell fate transitions.

3/ Surprisingly, P-body contents don't simply reflect current gene expression but are enriched with transcripts from the prior developmental stage. For example, in human naïve pluripotent ESCs, P-bodies sequester RNAs linked to the totipotent 8-cell embryonic stage.

2/ Using fluorescence-activated particle sorting, we profiled P-body contents across developmental stages and vertebrate species. P-body composition is cell-type specific, and the sequestered transcripts are translationally repressed.

🤔How do you design a promoter for stable titration of expression? 💡Try programmable promoter editing with DIAL! 📰Now published at @NatureBiotech 🧵 [1/n] 🔗 below

Thrilled to be selected as an #ISSCR2026 Ambassador! The @ISSCR 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 and features 4 days of cutting-edge stem cell science and global research talks. Learn more about the program:

Programmable promoter editing for precise control of transgene expression https://t.co/6jC9QnVgzn

The ISSCR joins the global scientific community in mourning the loss of Nobel Laureate Sir John Gurdon whose enduring influence is woven into the very fabric of stem cell science. https://t.co/AcCXggb5I7

Early career editor Bruno Di Stefano (@DiStefano_Lab) is presenting at the Cold Spring Harbor Laboratory "Cell Fate Conversions" meeting today in NY, USA. Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports! #cshldirect

Excited to join the Stem Cell Reports team as an Early Career Editor! Grateful for the opportunity to support the stem cell community and contribute to the journal alongside a fantastic group of colleagues. @ISSCR @stemcellreports

The ISSCR has selected five distinguished early career scientists to serve as new Early Career Editors for Stem Cell Reports, the peer-reviewed, open access, online journal of the International Society for Stem Cell Research (ISSCR). Learn more: https://t.co/MJnGcPn7gu

Excited to share our new study in Cell—congrats to Daniel, co-authors, and our collaborators in the @PeterLyLab What began as pure curiosity led to a tool for modulating mitochondrial abundance in vitro and in vivo. A new direction for the Wu lab begins!

Hear from Stem Cell Reports Editor-in-Chief Janet Rossant and Associate Editor Martin Pera about the countless opportunities the journal offers to amplify your research within the stem cell community. Learn how to publish your research 👉 https://t.co/yck5s9Iz1n @martinperaJAX

Selective RNA sequestration in biomolecular condensates directs cell fate transitions https://t.co/i2aOm6bf0B #biorxiv_cellbio

Selective RNA sequestration in biomolecular condensates directs cell fate transitions: