Xi Chen
@XiChenLab
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Associate Professor & CPRIT scholar @MDAndersonNews studying stress responses in tumor microenvironment and anti-tumor immunity.
Houston, TX
Joined September 2020
Many congratulations to @LV_Xiangdong who has been awarded the CPRIT scholar award to set up his own lab at @UTHealthHouston! He is amazing!.
BREAKING NEWS: #CPRIT approved $89 million in grants to advance the state’s fight against cancer, including CPRIT Scholar recruitment awards, evidence-based prevention programs and innovative companies developing new cancer drugs and treatments. READ:
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RT @JenWargoMD: Thank you @theNAMedicine @MDAndersonNews and all who contribute to our mission to #endcancer - patients and families, care….
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Inhibiting IRE1 RNase in TP53-mutant TNBC allows taxane to be highly immunogenic, triggering dsRNA-ZBP1-NLRP3-GSDMD pyroptotic signaling cascade, turning PD-L1-negative cold tumors hot, and conferring these cold tumors hypersensitivity to PD-1 inhibitor.
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Happy to share our latest work showing that an ancient ER-localized RNase IRE1 coordinates with p53 to silence taxane-induced dsRNA and protect immune-cold TNBC from pore-forming pyroptosis. @CellCellPress @MDAndersonNews
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RT @MDAndersonNews: Here are 10 things to know about our Dr. Jim Allison, who was recently elected to the 2024 National Inventors Hall of F….
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RT @jmancuso76: The Allison Institute will be hosting a Next Gen Colloquium in Houston ahead of SITC in November. Details in photo. Please….
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RT @Goodell_Lab: Recruiting faculty to the Dept of Molecular and Cellular Biology at Baylor College of Medicine in Houston! Recruiting broa….
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Wonderful session on #UPR and #ISR. Learned a lot from the amazing talks from @ACKoongMDPhD @Eric_Chevet @apoptosislab !.
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Kudos to @LV_Xiangdong @XuanLu11447800 and all authors for the fantastic teamwork. Thanks @NCICancerBio for supporting this work.
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Happy to share our latest work in collaboration with @HaoqiangY published in @ScienceMagazine today: Proteostasis network reprogramming is a key convergence point of multiple KRAS inhibitor resistance mechanisms.
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Happy to share our latest work with Stanley Adoro on identifying #ERAD as a critical protein quality control checkpoint for T cell development. @eLife @bcmhouston
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RT @NatureRevCancer: FEATURED Review in this month's issue: JR Cubillos-Ruiz @JCubRuiz & X Chen @XiChenLab discuss how #ERstress can influe….
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Thank you @Eric_Chevet @costas_koumenis and the anonymous reviewer for the insightful comments!.
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Excited to share our review with @JCubRuiz on ER stress in cancer @NatureRevCancer under the wonderful guidance of @annaedart ! @bcmhouston.
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Join us @bcmhouston. Fantastic department with incredible environment and support to start your lab!.
Recruiting faculty @bcmhouston! Multiple assistant prof positions in the MCB dept AND the Stem Cell Cntr! Looking for expertise in #epigenetics #generegulation #cellbio #synbio #organoids #stemcells… . Why consider BCM? Read on.
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Thank you @Goodell_Lab ! So fortunate to be in the amazing MCB department @bcmhouston with enormous support from Peggy and incredible colleagues!.
Please give a warm Twitter welcome to @XiChenLab who just joined. -Fantastic faculty member in MCB department @bcmhouston. Beautiful new @NatureCellBio paper on protein QC in #HSCs! Congrats!.
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Thank you @SignerLab for writing a wonderful and insightful News & Views highlighting our paper @NatureCellBio ! We love the title "ERADicating stem cells from their niche"!.
ERADicating stem cells from their niche. Our News & Views on exquisite new work from @XiChenLab in @NatureCellBio on how proteostasis regulation by the ERAD pathway influences the interaction of HSCs with their perivascular niche in the bone marrow.
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Very pleased to share our latest work on ER-Associated Degradation (#ERAD) as a critical protein quality checkpoint that controls HSC-niche interaction and determines the fate of HSCs. @NatureCellBio @bcmhouston .
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