Honggui Wu
@Wu_Honggui
Followers
804
Following
6K
Media
24
Statuses
494
Postdoc in Feng Zhang lab @BroadInstitute. Graduated from Sunney Xie Lab at Peking University.
Boston
Joined September 2017
Spatial methylome + transcriptome.
Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues #biorxiv_genomic.
0
0
4
Our scMicro-C paper is out in @NatureGenet! Huge thanks to the reviewers for their valuable insights, to @XieSunney for unwavering support, and to fantastic collaborators @JiankunZhang21 & @tanlongzhi. Thrilled to share this work!.
Very excited to share our work on high-resolution single-cell Micro-C, which is on bioRxiv now. Here we reveal that cohesin-mediated loop extrusion participates in transcription with kilobase-resolution single-cell 3D structures.
3
17
91
RT @LukensJohnR: Ironman. Maternal iron deficiency causes male-to-female sex reversal in mouse embryos .@Nature htt….
0
42
0
RT @BKleinstiver: In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-C….
0
72
0
RT @schumacherbj: 🔥🔥🔥OUR NEW PREPRINT: Slowing and reversing aging? Nature does it, here we show how! Age deceleration and reversal gene pa….
0
34
0
RT @SStevenWang: Introducing RAEFISH, our lab's new flagship image-based spatial transcriptomics technology that simultaneously enables sin….
0
55
0
RT @zhangf: We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGR….
0
265
0
RT @biorxiv_genomic: Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology .
0
17
0
RT @claballabio: Did you know cancer cells can be electrically active, just like neurons? This electrical activity plays a key role in tumo….
0
70
0
RT @Gerlich_Lab: New #preprint from our lab at @IMBA_Vienna !.How do DNA breaks locate homology sites in the vast space of the human genome….
0
13
0
RT @naturemethods: .@LanJiangBoston and colleagues developed droplet-based UDA-seq by incorporating a post-indexing step into two-round com….
0
5
0
It has been a wonderful collaboration with @MaoxuC, and I deeply appreciate @XieSunney 's support and guidance throughout the project.
0
0
3
dscHi-C allows us to investigate chromatin reorganization during mouse brain aging, while dscHi-C-Multiome reveals the complex relationship between genome structure and gene regulation. Learn more here:.
1
1
3
Thrilled to introduce a new single-cell 3D genome analysis tool to our toolkit! Our high-throughput droplet Hi-C (dscHi-C) and dscHi-C-multiome methods use droplet microfluidics to generate tens of thousands of single-cell Hi-C profiles with high sensitivity in a single batch.
5
27
148
RT @zanehkoch: WHY DOES THE EPIGENETIC CLOCK TICK?. While money has been poured into developing therapies to reverse the epigenetic clock (….
0
213
0
Congratulations!.
After my first public report at the Double Helix 70’s celebration ( on Oct 2023 and a bioRxiv on June 2024, FOOtprinting by dsDNA DeamInasE (FOODIE), the major effort of my CPL/PKU group, delayed by the pandemic, has been yearmarked by today issue of PNAS
0
0
10
RT @WilliamCQHua: A foundation model for enzyme retrieval and function prediction is released. EnzymeCAGE is trained on ~1M enzyme-reacti….
0
18
0
RT @nmoris: Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscl….
0
43
0
RT @aventura71: 1/ 🚨New paper on ecDNAs from our lab! . We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cel….
0
91
0
RT @biorxiv_genomic: The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sit….
0
3
0