Congratulations to Honggui, Jiankun, and Tan for improving the single-cell 3D genome resolution by a factor of 4 (to 5 Kb). This allowed direct visualization that multiple enhancers cluster to a particular gene promoter at the same time in a single cell.

Congrats to Rita, Ji-Xin, Wei and Meng for the special issue of Nature Methods on vibrational imaging (. Happy to share my account for the 25 years of Nonlinear Raman imaging. Thanks to all former group members and collaborators for their contributions.

Congrats to Xinyao and Xie Chen! In eukaryotes, multiple transcription factors bind cooperatively to a regulatory region on genomic DNA to control gene expression. In this paper (, we present an experimental metric for quantifying such cooperativity.

Happy to share Prof. Bing Ren and Lei Chang’s Commentary in PNAS regarding our recent work on FOODIE. Thanks to their comprehensive, easy to understand explanation and expert appraisal.

After my first public report at the Double Helix 70’s celebration ( on Oct 2023 and a bioRxiv on June 2024, FOOtprinting by dsDNA DeamInasE (FOODIE), the major effort of my CPL/PKU group, delayed by the pandemic, has been yearmarked by today issue of PNAS

Congratulations to Honggui, Jiankun, Fanchong and Tan on the invention of the LiMCA technique which provided new understanding of the "one receptor one neuron" phenomenon. Thanks Stavros for writing a commentary about our article.

Video archive for the symposium celebrating DNA Double Helix's 70th on Changping Laboratory's 3rd anniversary, Oct 21-22, 2023 in Beijing. Thanks to J. Watson, T. Maniatis, S. Balasubramanian, other speakers and contributors for the memorable event.

Glad to share our paper on precise sequencing of the methylome of a single cell free of bisulfite by CABERNET (after MALBAC, MARSALA, LIANTI & SHERRY). It measures 5mC & 5HmC separately & enables many new exp. Kudos to Yunlong, Yali & Tianjiao & the team!.

Our contribution to Steve Boxer's Festschrift issue of JPC-B. Happy 75th, Steve!.With single-cell proteomics of steady-state cells, we observed Correlated Protein Modules representing groups of proteins working together in certain biological processes.

Congrats to @Wu_Honggui @JiankunZhang21 @tanlongzhi. By achieving the highest resolution of single-cell 3D genome structures (5kb) with scMicro-C, we proved the involvement of cohesin-mediated loop extrusion in human transcription, for the important function of fast reinitiation.