Weiser Lab @ NYU Langone Health
@WeiserLabNYU
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We study the molecular basis for host-pathogen interactions in the respiratory tract. Twitter run by lab members. Likes/RTs are not endorsements.
New York, NY
Joined August 2020
Profiling of pneumococcal population structure during infection reveals an unappreciated role of bacteriocins in driving the development of pneumonia by facilitating the release of inflammatory mediators https://t.co/RnHSLwAugP
nature.com
Communications Biology - Profiling of pneumococcal population structure during infection reveals an unappreciated role of bacteriocins in driving the development of pneumonia by facilitating the...
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Excited to share our latest work studying pneumococcal pneumonia. We found that pneumococcal population structures undergo massive changes within the lung. This bacteriocin-mediated turnover of the population "promotes" pneumococcal pneumonia https://t.co/eAOhtMJ7Hv
nature.com
Communications Biology - Profiling of pneumococcal population structure during infection reveals an unappreciated role of bacteriocins in driving the development of pneumonia by facilitating the...
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🚨Excited to share our new study below!🚨 1/7: Childhood mortality from bacterial respiratory & enteric pathogens remains a global concern. But what compromises infants' ability to fight infections? Our study delves into the immune deficiencies intrinsic to early age.
Why are infants susceptible to invasive pneumococcal diseases? Excited to share our latest work led by @LokkenToyli which explores this question and elucidates the age-dependent mechanisms that drive pneumococcal spread from the mucosa. @PLOSPathogens
https://t.co/98o6PyLWsf
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Why are infants susceptible to invasive pneumococcal diseases? Excited to share our latest work led by @LokkenToyli which explores this question and elucidates the age-dependent mechanisms that drive pneumococcal spread from the mucosa. @PLOSPathogens
https://t.co/98o6PyLWsf
journals.plos.org
Author summary In children, bacterial respiratory and gastrointestinal pathogens remain major contributors to childhood mortality worldwide. Yet, the immune deficiencies intrinsic to early age that...
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I’m biased, but this is such a cool paper and very happy that it’s now published @NatureComms 😀Congratulations to Anne-Stéphanie @vrrenske @suryad26 @WeiserLabNYU @LalouxLab @santosmoreno_j @YSchaerli!
nature.com
Nature Communications - Here, Rueff et al engineered a CRISPRi-based oscillator to rewire capsule production in Streptococcus pneumoniae from its native control. They show that heterogeneity in...
Is phenotypic variation functional? Stoked about our latest preprint spearheaded by the amazing Anne-Stephanie @DMF_UNIL @unil in collaboration with a fantastic team of people @vrrenske @suryad26 @santosmoreno_j @LalouxLab @YSchaerli @WeiserLabNYU
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Is phenotypic variation functional? Stoked about our latest preprint spearheaded by the amazing Anne-Stephanie @DMF_UNIL @unil in collaboration with a fantastic team of people @vrrenske @suryad26 @santosmoreno_j @LalouxLab @YSchaerli @WeiserLabNYU
biorxiv.org
Phenotypic variation is the phenomenon in which clonal cells display different traits even under identical environmental conditions. This plasticity is thought to be important for processes including...
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Congratulations to our newly minted PhD - Dr. Bee (@cwb315) did a fantastic job showcasing his research in the lab over the past 6 years! Well done 🎉🎊🍾
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Excited to see Gavyn @cwb315 from @WeiserLabNYU @nyulangone defend his thesis defense. starting now! Brilliant and touching intro from Jeff! here we go!
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Happy to share our latest work from @cwb315 that was published in @ImmunityCP earlier today!! Here is a tweetorial summarizing the major findings from this work.
Feels surreal but here it goes! Elated to share that my primary research from @WeiserLabNYU @nyugrossman @nyulangone is now out at @ImmunityCP! Tweetorial ahead! 1/n 🧵 https://t.co/Bg6SosK5iN
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A selfish bacteriocin dictates pneumococcal domination:Trappetti/Paton discuss @suryad26 @WeiserLabNYU work on population dynamics of S.pneumoniae colonization. Bacteriocin promotes survival of lineages, providing population bottleneck & limiting diversity
cell.com
Efficient colonization of new hosts is critical for survival of Streptococcus pneumoniae. In this issue of Cell Host & Microbe, Aggarwal et al. investigate the population dynamics of this process,...
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A selfish program reduces S. pneumoniae diversity. Intra-strain competition upon #Spneumoniae colonization causes loss of clonal diversity. Bacteriocins induced by BlpC led to predation of kin & tightening of population bottlenecks @suryad26 @WeiserLabNYU
https://t.co/SRB9EPSFpL
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Excited to share that this story by @suryad26 is now out at @cellhostmicrobe! Check it out, and tweetorial below! https://t.co/JJ6ITHJpJj
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Pleased to share some of our latest work available online now in @cellhostmicrobe. In this work, we discovered that quorum sensing induced bacteriocins mediate intra-strain competition in pneumococcus during colonization and transmission. https://t.co/wA8l9ZTMNz
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Congratulations to graduate student Sheya @ma_sheya for passing her qualifying examination and becoming a PhD candidate. Looking forward to all the discoveries she’ll make in the lab.
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Excited to share our latest from @suryad26, now on @biorxiv! We describe the unexpected role of BlpC in driving intra-strain competitive success, with physiological consequences on ecology of the colonizing strain and importantly, transmission to new hosts! Tweetorial below.
Happy to share this manuscript where we study the population dynamics of pneumococcus during colonization and transmission. We used chromosomal barcoding to examine how the population structure of pneumococcus changes following infection. (1/n)
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We also welcomed our new tech Lucas Zhu who is joining us after graduating from Haverford College! Can’t wait to see all the cool science you do.
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We celebrated our lab tech, Annie Abruzzo’s last day with an ice cream party. Good luck to Annie as she starts med school next month!
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Key point: Our data suggests a "winner-takes-all" scenario, whereby serotype is a crucial factor in determining early niche dominance of the strain in the upper respiratory tract, and the dominant strain is able to exclude competing strains via fratricide.
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Excited to share our latest work at @mbiojournal, where we dissect the role of serotype on pneumococcal colonization dynamics and transmission using isogenic capsule-switch mutants and in vivo competitive assays! https://t.co/g5DwSzOlFx
journals.asm.org
Capsule is the major virulence factor and surface antigen of the opportunistic respiratory pathogen Streptococcus pneumoniae (Spn). Strains of Spn express at least 100 structurally and immunologica...
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