Lei Wang
@WangUCSF
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Professor @UCSF, @PharmChemUCSF, CVRI, and @UCSFCancer Genetically encoding unnatural amino acids to study biological processes and to develop biotherapeutics.
San Francisco
Joined December 2021
RT @Stanford_ChEMH: The first session ‘Cell surfaces and their interactions’ features talks from @CarolynBertozzi, @ZevGartner, Balyn Zaro….
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RT @angew_chem: Arginine Accelerates Sulfur Fluoride Exchange and Phosphorus Fluoride Exchange Reactions between Proteins (Lei Wang and co-….
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Our department is hiring! Ladder Rank Faculty Position – Assistant, Associate, or Full Professor: We seek creative, innovative scientists who define and address fundamental questions in diverse areas relevant to our Department.
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Biospecific Chemistry allows for the selective covalent targeting of endogenous biomacromolecules in vivo without altering the biomacromolecules themselves.
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The forefront of click chemistry, Phosphorus fluoride exchange (PFEx), reaches new heights in protein environments! Our research reveals PFEx activates through proximity, showing unique properties. @Chem_CP.
Online now: Genetically enabling phosphorus fluoride exchange click chemistry in proteins
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How does proximity-enabled SuFEx (the new generation of click chemistry) behave in protein context? - find out in Chemical Science .@ChemicalScience @PaulKlauser
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What if we have AI as editors!.
Rejection of your paper or grant has NO relevance to the opinion of #research community. It is nothing but the opinion of one person. Several examples:. 1. The first paper on graphene was rejected from Nature because “it did not constitute a sufficient scientific advance”.
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We have developed a covalent nanobody that binds its target irreversibly via PERx. Using this nanobody as delivery vehicle for radionuclides enhances PET imaging and antitumor effects! Thanks to fantastic colleagues at UCSF. @PaulKlauser @mikeevans_ucsf
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Amazing science and tremendous impact! Congrats to Kevan! .Science World Honors Kevan Shokat for High-Impact Cancer Research
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We feel so very honored! Lucky to apply click chemistry to glycobiology; both fields are pioneered by this year's Nobel Laureate!.
Catching up on some reading and just saw this beautiful #glycotime work from @WangUCSF @NatureChemistry, chemical crosslinking of glycan binding proteins and their ligands with genetically encoded covalent trap.
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Our latest #research on creating covalent linkages between proteins and carbohydrates, published with .@SpringerNature in @NatureChemistry, allowing one to irreversibly lock proteins with bound carbohydrates for researching and engineering.
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Our latest #research with @YinShenLab on creating covalent linkages between proteins and RNAs, published with @SpringerNature in [@NatureChemistry], allowing one to irreversibly lock proteins with bound RNA in vivo for researching and engineering.
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Congrats to Barry for the awoken "sleeping beauty"! Congrats to @CarolynBertozzi -- seeing her group started from UCB when I was a graduate and being amazed ever since! Thanks all for the great chemistries for our chemical biologists.
BREAKING NEWS: .The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Amazing day 1 at #QBIChemBio22 with ~500 chemical biologists from @UCSF @UCB_Chemistry @Stanford_ChEMH
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RT @UCSFHospitals: #Tumor cells can be tricky and good at evading the #ImmuneSystem, but an exciting new therapy can help target those cell….
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