Zaro Lab
@ZaroLab
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Studying hematopoiesis and innate immunity using Chemical Biology and Proteomics @UCSF. Student-run, message to learn more or if you have cool science ideas!
San Francisco, CA
Joined August 2011
Thanks to our @UCSF team of scientists and surgeons (some both!) lead by @ZaroLab student @ReganVolk with help from: @BaharZirak @TomPolli1 @Maker_MD @vram142 @genophoria and others not on this dying platform.
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You are what you eat! We leveraged chemical proteomics to discover that macrophages redeploy intact surface proteins made by their cancer cell meals during phagocytosis. These proteins are functional, and redeployment may explain the etiology of the TAM.
biorxiv.org
Macrophage-mediated phagocytosis is a vital innate immune process altered in cancer. We show here that tumor-associated macrophages (TAMs) redeploy intact cell surface proteins from cancer cells to...
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So excited to share this story with the world! A mimic of the mammalian ‘don’t eat me’ signal CD47 encoded by a pathogen!.
How thrilling to see this online after 8 years in the works!!!. We showed that #Lyme bacteria .mimic our own“don’t eat me” signal with their P66 protein to hide in plain sight!!! This tricks our SIRPa protein to trigger the breaks on immune clearance!.
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RT @genophoria: Check out this new preprint/white paper from our friends at Entwine bio together with @vram142 and @ZaroLab. We and others….
biorxiv.org
Predicting molecular function directly from DNA sequence remains a grand challenge in computational and molecular biology. Here, we engineer and train bidirectional transformer models to predict the...
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RT @basktastic: 🚨It's live! Check out the ACS Chem Biol special issue highlighting the rich living history of click & bioorthogonal chemist….
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The @UCSF Mission Bay Innate Immunity Working Group now has a website! Keep updated on future meetings and access available immunology resources. If you’re interested in presenting, reach out to @ZaroLab or @DrEmilyGoldberg 🧪.
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Excited to see this awesome resource by @annesapiro out on biorxiv. Thanks for letting us be a part of this project.
Curious how the Lyme pathogen changes as it moves through ticks during bloodmeal transmission? Us too - and it took a lot of blood sweat and tears (and ticks) for @annesapiro to crack this one. Let us know if you need help navigating our data!
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RT @seemaychou: Curious how the Lyme pathogen changes as it moves through ticks during bloodmeal transmission? Us too - and it took a lot o….
biorxiv.org
Borrelia burgdorferi ( Bb ), the causative agent of Lyme disease, must adapt to vastly different environments as the bacterium cycles between the tick vector and a vertebrate host. During a bloodme...
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RT @biorxivpreprint: Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission ht….
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We are thrilled to be a part of this incredible project. Thank you for the opportunity, @ElectrosomeUCSF!.
Channel:chaperone cryoEM structure. Super talented team Zhou, Abhisek, &Fayal with @ZaroLab. EMC twists, turns, and extracts a pore domain. EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms
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Congrats @hitenmadhani @EricVDang1!! Thanks for letting us be a part of this fabulous project!.
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First pre-print from the macrophage side of the lab! Way more to come, but we are stoked to start sharing our work with the community! Congrats @ReganVolk @Chemystified Sara and Kate!.
I am happy to share the latest paper out of the Zaro lab and the first of my first author publications, “Proteomic Characterization of Phagocytic Primary Human Monocyte-Derived Macrophages” now available on @ChemRxiv
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Special thanks to @BeckmanFnd for funding and @FujimoriLabUCSF @MattRPratt for feedback on the manuscript!.
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Proud to share our lab’s first preprint @ucsf! This project started as a small rotation project and quickly turned into something to super exciting!.
Thrilled to share that the Zaro Lab's first ever preprint is now LIVE on @ChemRxiv 🧪 We developed a new, highly-selective (like, *really* selective) covalent inhibitor of BTK through the simple elaboration of fumarate ester-based warheads (1/n):
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RT @hollyingrahamSF: Hey scientists - @UCSF is hiring - remember you don’t need a CSN paper or a K. We are looking for fresh ideas, curiosi….
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Thrilled to announce that we have been awarded a BYI for our work involving bacterial mimicry of mammalian ‘don’t eat me’ signals! Congrats to an impressive list of other awardees across the country! Proud to join the ranks of other BYIs @UCSF!.
Congratulations to the 2021 Beckman Young Investigator Awardees! Read the full announcement: #UHouston #UCSC #PennState #Emory #UVa #NYU #MIT #UNC #ChapelHill #UCSF #UIUC
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RT @WomenScienceRFS: "This is a first for the chemistry prize – or any Nobel prize we believe. Two women have never been the sole nominees….
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RT @IanSeiple: Is chemistry authorship gender-balanced? @adamcotton92 wrote a web scraper to mine PubMed for authors' names and countries,….
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Thanks @FujimoriLabUCSF Promoting Black and other minority scientists is crucial for the evolution of science. We stand with our allies to fight racism and discrimination. I’m nominating 5 others to do the same. @MattRPratt @DrEmilyGoldberg @raflynn5 @abbybuch @DanieleCanzio.
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