WaelSSKamel
@WaelSKamel
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Studying RNA regulation during virus infection @CVRinfo 🏴 Before @UniofOxford 🇬🇧 @UU_University 🇸🇪 @CairoUniv 🇪🇬
Glasgow, Scotland
Joined August 2014
It is finally OUT!! After a pandemic, lab moving across the country!, 1+ under review and >120 panels later. 🧵 https://t.co/yFpXHpVnS5
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They should teach this in every school: EVERYTHING you learn, even basic math, decays over time unless you use it regularly in daily life or make a deliberate effort to practice it. This phenomenon is known as Ebbinghaus’s Forgetting Curve.
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Proud to announce my first publication is out in @PLOSPathogens ! Huge thanks to my co-first author Wael, @brennanlab, and @castello_lab. The paper explores how tick RNA-binding proteins respond to UUKV infection, you can find the paper here https://t.co/HNsotnsKWK
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Online Now: FMRP drives mRNP targets into translationally silenced complexes https://t.co/KHw3hSz9pA
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📃 NEW PUBLICATION | The immune system’s energy sensor revealed in new research Research from Fletcher Lab shows that RNF213 senses ATP to trigger immune defence, revealing a link between energy and immunity. https://t.co/oB19cDKz72
@Ardabalci01 @UofGMVLS @NatureComms @UofGSii
nature.com
Nature Communications - RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation...
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New in Nature Comms: We applied metagenomic and targeted NGS to serum samples from undiagnosed febrile patients across Uganda. This work highlights how NGS can transform viral surveillance in LMICs—especially with infrastructure now in place post-COVID. 🔗
nature.com
Nature Communications - Acute febrile illness is common in sub-Saharan Africa and causative agents are often unknown. Here, the authors perform metagenomic sequencing on samples from patients with...
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Following our recent publication, here’s a striking collage of developing fly brain! 🧠✨ Highlighting the dynamic expression of RNA-binding proteins Imp (green) and Syp (magenta) https://t.co/zCqJzAyUH3
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5/ Sure, it’s great to have machine learning skills (I am going over the course on https://t.co/iYurXUBJss too), but bioinformatics isn’t just about flashy models. It's about knowing when to trust your data and when to question it.
fast.ai
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4/ Unfortunately, it’s becoming harder to find bioinformaticians who can double-check results, question their data, and say, “Wait, does this make sense biologically?” instead of rushing to fit the latest deep model.
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Second fully funded PhD in our lab! @EdinUni_IRR @zje_institute @edin_EID . How do endogenous retroelements shape bat immune responses? Fully funded PhD plus teaching in China. Excellent supervisors include @BatResearch and @BrookLab3. #lovevirology
https://t.co/1wQKSUleDk
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🦸 Hidden superheroes in our cells!? New research led by @WaelSKamel, @castello_lab & @RosFrankInst, has uncovered how a team of cellular “superheroes” leap into action to stop viruses in their tracks. Find out more: https://t.co/HTGuArj4Do The study:
gla.ac.uk
From hard-working newspaper reporter to world-saving superhero, Clark Kent makes the transition to Superman in just a few seconds. Now, scientists have discovered that human cells are home to their...
🆕 New research finds the ‘Clark Kent’ of cells, secretly fighting to protect us from viruses. In the study, scientists have discovered that human cells are home to their own hidden superheroes, covertly helping us to fight off a range of viruses. More➡️ https://t.co/Dt8ziy6Nn9
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Cake time!!! We literally ate our model!! and ...it is delicious😋
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Progress in science comes when experiments contradict theory.
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Delighted for @WaelSKamel. This was a rollercoaster ride. For more details and what we learned (very cool) see thread
It is finally OUT!! After a pandemic, lab moving across the country!, 1+ under review and >120 panels later. 🧵 https://t.co/yFpXHpVnS5
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Finally, it has been invaluable experience to co-lead this project with my amazing mentors @Alf_Castello and @FranklinSystems who showed me the beauty of integrating RNA biology with proteomics to explore the hidden aspects of virus infection.
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This work would not have been possible without the excellent team work and collaboration especially members of @castello_lab /@CVRinfo and @FranklinSystems
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Among these proteins, the U2 snRNP including U2 snRNA appears to assemble on the viral RNA and inhibit viral replication in U2 snRNA -dependent manner.
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Additional data shows that these relocalised nuclear proteins can be found in proximity of virus replication centers in the cytoplasm
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Subcellular fractionation and proteomics shows 1) these nuclear proteins relocalise to the cytoplasm upon infection and 2) Viral RNA is their main destination
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It is all started with the observation that some strictly nuclear proteins, with no known cytoplasmic function, interact with cytoplasmic viral RNA during SINV infection.
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