
Alfredo Castello
@Alf_Castello
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Professor at the MRC-University of Glasgow Centre for Virus Research
United Kingdom
Joined May 2017
New publication from @castello_lab and @FranklinSystems in @MolecularCell 🚨🚨🚨! We discover a group of nuclear #RBPs that travel to the cytoplasm to inhibit #virus #infection. We discover a novel #RNA mediated antiviral mechanism mediated by the U2snRNP
cell.com
Kamel et al. apply complementary approaches to elucidate the composition of Sindbis virus ribonucleoproteins. They identified a subset of nuclear proteins that selectively translocate to the cytopl...
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RT @Eileen_Furlong: To all post-docs: The Genome Biology dept @embl has an Independent faculty position. Fantastic place to set up your lab….
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RT @CVRinfo: Prof Emma Thomson joined Dr Stella Atim, Dr Catherine Houlihan & Dr Naomi Walker to author a chapter on Viral Haemorrhagic Fev….
cambridge.org
Principles of Medicine in Africa - June 2025
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RT @GlattSebastian: Dear all,. We are starting an exciting project with @ClmentCarr5 in Paris, France. A fully funded PhD position is ava….
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🚀 In Communications Biology: a dsRNA interactome mapped via K1 IP + quantitative MS identifies >100 host dsRBPs regulating IFN-β signaling and antiviral defense during HCoV‑OC43 infection. A rich resource for antiviral and RNA‑RBP communities! 🔗
nature.com
Communications Biology - Exploration of dsRNA interactome using the K1 antibody and functional studies using CRISPR-Cas9 knockout screening of these dsRBP candidates elucidate the role of dsRNA...
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RT @CVRHutchinson: Fantastic thread from @DanielWeirIAV explaining his new paper on how flu drives dying cells to reach out and infect thei….
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Here’s a tweet you could post on X:. > 🧬 New from the @Castellolab & Mohammed labs, led by Louisa Iselin: Type I interferon doesn’t just turn on the expression of interferon stimulated genes, it globally remodels the RNA-bound proteome #RNA #Interferon
biorxiv.org
The type I interferon (IFN-I) response shapes the intracellular environment to supress virus infection. Historically, this remodelling has been linked to the transcriptional induction of interferon...
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RT @GeraldGmboowa: Genomic epidemiology of mpox virus in Sierra Leone reveals sustained human-to-human transmission with limited importatio….
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So glad to see this paper out, @E3ligase. Awesome job 🎉🎉🎉. Congratulations!!!.
📃 NEW | Cellular Energy Sensor Reveals New Pathway for Fighting Infections. A giant cellular protein, RNF213, acts as an 'energy sensor' detecting rising ATP levels during infection and activating defences. @Ardabalci01 @E3ligase @UofGMVLS.
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RT @CVRinfo: 🎉 SHORTLISTED || Congratulations to Dr Emilie Pondeville (@emipondeville) for being shortlisted for the Trophées des Français….
lepetitjournal.com
Découvrez les 5 finalistes du Trophée Innovation des Trophées des Français du Royaume-Uni, parrainé par ZappTax.
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RT @yiweichang: . and big thanks to @janetiwasa for making this amazing video to illustrate the strand-sliding mechanism! .
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RT @Nature: An innovative genome-editing tool promises to do what original CRISPR systems have struggled to achieve: insert entire genes, p….
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RT @CVRinfo: 📢 You have until Friday 30th May to submit an abstract to present at this year's #GlasgowVirologyWorkshop! . We'd love to hear….
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RT @jmuiuc: We introduce #POPARI, an interpretable, spatially-aware factor-based model for multi-sample #spatialtranscriptomics. Huge kudos….
biorxiv.org
Integrating spatially-resolved transcriptomics (SRT) across biological samples is essential for understanding dynamic changes in tissue architecture and cell-cell interactions in situ . While tools...
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RT @SpyrosLytras: Sooo happy to finally have this one published!! (3 years in the making… 👀) A comprehensive investigation into the recency….
cell.com
Recombination-aware evolutionary analyses of the entire genomes of SARS-CoV-1-like and SARS-CoV-2-like viruses indicate that SARS-CoV-1 and SARS-CoV-2 descend from bat coronaviruses that circulated...
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RT @RBPReguNET: The RBP-ReguNet consortium is meeting in Paris for an exciting review and scientific session hosted by @institut_curie! htt….
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RT @RentmeisterLab: Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and….
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