Shabaz Lab
@ShabazLab
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Focus on developing proteomics technologies so mostly relates to sample prep, MS and LC. Oxford PI (Shabaz Mohammed) seconded to the Rosalind Franklin Institute
Harwell Campus and Oxford Uni
Joined July 2020
We asked the question do solid particles have a role to play in the separation space within modern proteomics? Would these very small particles in short columns for fast gradients be a good idea for modern fast and sensitive MS? The answer was not no! https://t.co/XGYdnPQcC4
pubs.acs.org
We evaluate the performance of nonporous C-18 stationary phases in high-speed proteomics workflows. We employed two commercially available sub-2 μm nonporous particle (NPP) materials, ODS-IIIE (1.5...
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Proud to announce my first publication is out in @PLOSPathogens ! Huge thanks to my co-first author Wael, @brennanlab, and @castello_lab. The paper explores how tick RNA-binding proteins respond to UUKV infection, you can find the paper here https://t.co/HNsotnsKWK
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🚨 New paper in @PLOSPathogens! 🚨 Together with @brennanlab, we mapped – for the first time – how tick RNA-binding proteins rewire during virus infection. 283 proteins changed activity, revealing key players in viral fitness. Read here:
journals.plos.org
Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions....
Proud to announce my first publication is out in @PLOSPathogens ! Huge thanks to my co-first author Wael, @brennanlab, and @castello_lab. The paper explores how tick RNA-binding proteins respond to UUKV infection, you can find the paper here https://t.co/HNsotnsKWK
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We were just using NHS chemistry for some protein conjugation when we noticed some odd prominent side products. It turns out thio-nhs reagents (a major class of reagents) has some notable side reactions that happen all the time. https://t.co/5OyIib7QSR
nature.com
Nature Communications - N-Hydroxysuccinimide (NHS)-ester derivatives are one of the most widely used acylating agents. In this work, the authors report that ring-opening reaction of the succinimide...
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So Nikita really wanted to present his poster (ThP648) on the omnitrap at #ASMS2025. Well with the power of the internet he can! Visa be damned. Also he is fresh and not destroyed by all the vendor hospitality...
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Here's an LC story from our lab. Unlike a lot of stories with questions as titles this one is a maybe yes! Interesting for those high throughput proteomics people! https://t.co/FXljoHfRcU
biorxiv.org
We evaluate the performance of nonporous C-18 stationary phases in high-speed proteomics workflows. We employed two commercially available sub-2 µm nonporous particle (NPP) materials, ODS-IIIE (1.5...
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Deadline is fast approaching!
The Brixen summer school speaker list has been finalised. It's going to be another fantastic edition!
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🚨🚨News: Interested in the proteome configuration that makes a cell permissive or hostile to virus infection? Why mRNA levels do not fully reflect the proteome status after interferon treatment? See the new paper from @castello_lab and Mohammed lab https://t.co/LVJYpF2TSs
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We are excited to share our new Nature Methods paper describing the Chip-Tip workflow for single-cell proteomics identifying >5,000 proteins in single cells, enabling PTM analysis without enrichment and throughput of up to 120 single cell samples per day: https://t.co/ZI19WxwzlK
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The Brixen summer school speaker list has been finalised. It's going to be another fantastic edition!
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First announcement! The Brixen Summer School is back and is, as usual, building up a strong speaker list. Thank you @EuPAProteomics @msaid_de @thermofisher @biognosys @EvosepBio @SIGNATOPE_GmbH
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🦸 Hidden superheroes in our cells!? New research led by @WaelSKamel, @castello_lab & @RosFrankInst, has uncovered how a team of cellular “superheroes” leap into action to stop viruses in their tracks. Find out more: https://t.co/HTGuArj4Do The study:
gla.ac.uk
From hard-working newspaper reporter to world-saving superhero, Clark Kent makes the transition to Superman in just a few seconds. Now, scientists have discovered that human cells are home to their...
🆕 New research finds the ‘Clark Kent’ of cells, secretly fighting to protect us from viruses. In the study, scientists have discovered that human cells are home to their own hidden superheroes, covertly helping us to fight off a range of viruses. More➡️ https://t.co/Dt8ziy6Nn9
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Very proud of Innes Jarmson, who had the thesis viva yesterday! Congratulations, it has been a pleasure to supervise you. We wish you all the best for the future 🏆🍾🥂🥂🎉🎉🎉
Delighted to share Inner Jarmson successfully defended his PhD thesis on identification of #RNA editing #enzymes involved in #virus infection. He did an amazing job defending his work in viva. Congratulations to Innes for his dedication and hard work! We are very proud of you!
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New publication from @castello_lab and @FranklinSystems in @MolecularCell 🚨🚨🚨! We discover a group of nuclear #RBPs that travel to the cytoplasm to inhibit #virus #infection. We discover a novel #RNA mediated antiviral mechanism mediated by the U2snRNP
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Delighted for @WaelSKamel. This was a rollercoaster ride. For more details and what we learned (very cool) see thread
It is finally OUT!! After a pandemic, lab moving across the country!, 1+ under review and >120 panels later. 🧵 https://t.co/yFpXHpVnS5
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It is finally OUT!! After a pandemic, lab moving across the country!, 1+ under review and >120 panels later. 🧵 https://t.co/yFpXHpVnS5
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Had a great time at #HUPO2024 presenting our recent work using phosphoproteomics to characterise cellular quiescence in glioblastoma @uclcancer
Great talk from @EmilyGaizley where she describes her new low cell number phospho proteomic workflow and how she used it to discover and follow up novel targets in quiescent glioblastoma cells. #hupo2024
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New intake of PhD students joining the 'NGC' group meeting and learning at the 'problems session' that chemistry (and its curly arrows and fish hooks) is a key foundation for interdisciplinary science. 100% true. don't @ me! @RosFrankInst
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