Vijay K. Yadav (VJ) Profile
Vijay K. Yadav (VJ)

@VijayYadavLab

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Scientist investigating the biology of aging

Rutgers University
Joined September 2019
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@VijayYadavLab
Vijay K. Yadav (VJ)
2 years
New in @sciencemagazine we report a role of taurine deficiency as a driver of aging. I thank all the collaborators and funders as well as my present and past institutions in USA, UK and India for supporting my team.
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@VijayYadavLab
Vijay K. Yadav (VJ)
17 hours
#Taurine as a potential #prophylactic or #therapeutic agent to reduce symptomatic #malaria.
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@VijayYadavLab
Vijay K. Yadav (VJ)
7 days
#Nonuniversality of #inflammaging across #human populations. Wonderful work from Alan Cohen @ColumbiaAging
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@VijayYadavLab
Vijay K. Yadav (VJ)
13 days
Long road from #animal research to #humans. #Taurine was first noted as beneficial for stroke and #cardiovascular diseases prevention in stroke-prone spontaneously #hypertensiverats. Okamoto K et al., Jpn Circ J. 1963, 27: 282-293. For further read:
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@VijayYadavLab
Vijay K. Yadav (VJ)
13 days
#Taurine ameliorates #blood pressure and #vascular function in patients with type 2 #diabetes: Randomized, double-blind, placebo-controlled clinical trial.
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@VijayYadavLab
Vijay K. Yadav (VJ)
14 days
For further read please see:
@VijayYadavLab
Vijay K. Yadav (VJ)
24 days
A reccent important study in the area of taurine biology by De Cabo's group provides new insight into changes in blood taurine levels in humans. In response to requests and tags I thought I will provide my point of view. @NirBarzilaiMD @davidasinclair @EricTopol @mkaeberlein.
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@VijayYadavLab
Vijay K. Yadav (VJ)
14 days
Nice to see some media outlets stay with available scientific evidences when writing news articles.
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@VijayYadavLab
Vijay K. Yadav (VJ)
14 days
Wonderful work @NicholasRattray.
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@VijayYadavLab
Vijay K. Yadav (VJ)
14 days
For further details see:
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@VijayYadavLab
Vijay K. Yadav (VJ)
14 days
These results are consistent with taurine's role in senescence. We showed that taurine deficiency increases, and taurine supplementation in aged mice decreases, abundance of senescent cells. Taurine reduced accumulation of senescent cells in telomerase deficient zebra fishes.
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@VijayYadavLab
Vijay K. Yadav (VJ)
15 days
Low intracellular levels of #taurine is a common metabolic feature of several #senescence induction conditions (#Etoposide, #irradiation, #cell passage, #hydroxyurea)—Can it be a new marker for senscence? is taurine a #senolytic, #senomorphic or both?
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@VijayYadavLab
Vijay K. Yadav (VJ)
15 days
#Aging leads to depletion of #taurine in the mouse somatosensory cortex and taurine supplementation mitigates aging-related plasticity #decline.
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@VijayYadavLab
Vijay K. Yadav (VJ)
15 days
Tissue depletion of #taurine accelerates skeletal muscle #senescence and leads to early death in mice.
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@VijayYadavLab
Vijay K. Yadav (VJ)
15 days
Structural basis of #taurine regulation of #aging hallmarks and cellular #senescence through its transporter. This work offers new avenues for developing #interventions to combat cellular aging.
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@VijayYadavLab
Vijay K. Yadav (VJ)
16 days
RT @NewsfromScience: With research papers becoming increasingly free to read and use, understanding #OpenAccess licenses is key. https://t.….
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@VijayYadavLab
Vijay K. Yadav (VJ)
24 days
However, taurine blood levels are highly variable in adults and thus at the present time taurine cannot be used a biomarker to predict health or aging.
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@VijayYadavLab
Vijay K. Yadav (VJ)
24 days
In summary, taurine deficiency accelerates the pace of aging because if you supplement animals (worms, mice, monkeys) they live longer and healthier, and conversely if you make animals taurine-deficient they have poor health and have 40% shorter lifespan.
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@VijayYadavLab
Vijay K. Yadav (VJ)
24 days
We have just included the last participant and expect that we will have all the samples by the end of 2025 with analysis thereafter. This trial will hopefully generate sufficiently robust evidence to answer the question whether taurine supplementation slows human aging.
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@VijayYadavLab
Vijay K. Yadav (VJ)
24 days
Next step of this research is us, humans. We are part of a double-blind, randomized, controlled trial to find out how half a year of daily taurine supplementation affects the estimated biological age, organ ages as well as health variables when compared to placebo.
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@VijayYadavLab
Vijay K. Yadav (VJ)
24 days
Others and we have shown that taurine deficiency in animals results in significant health problems whereas increasing taurine through a pill improves health parameters and increases health and lifespan in animal models. Together this suggests that taurine deficiency is a problem.
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@VijayYadavLab
Vijay K. Yadav (VJ)
24 days
This was first demonstrated by two papers in Science in 1975 and 1987 that showed that taurine deficiency causes blindness and heart failure in cats and dogs.
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