Vijay K. Yadav (VJ)
@VijayYadavLab
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Scientist investigating the biology of aging
Rutgers University
Joined September 2019
New in @sciencemagazine we report a role of taurine deficiency as a driver of aging. https://t.co/lVd5w4SoEr
https://t.co/eqx9F8hXdE I thank all the collaborators and funders as well as my present and past institutions in USA, UK and India for supporting my team.
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Happy to share my students’ study @CellReports Parvalbumin interneurons in the insular cortex control social familiarity and emotion recognition: Cell Reports
cell.com
Fujima et al. employed microendoscopic calcium imaging and chemogenetic manipulation to elucidate the pivotal role of parvalbumin-positive interneurons in the agranular insular cortex. These neurons...
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Tried my hands on making, in a healthy way, Bhuna Gosht (Goat meat) for Saturday dinner. My son enjoyed it with rice and home made roti and said it is the best meat he has ever had, which made up for all the efforts!!
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Taurine levels correlate with thyroid function in humans and taurine supplementation shows beneficial effects on thyroid functions in animal models. Will it do the same in humans? https://t.co/rg17yBUlUm
https://t.co/pRvr8hfTag
pubmed.ncbi.nlm.nih.gov
There is a growing global interest in hypertension due to its associated complications including renal dysfunction in patients. The thyroid system reportedly regulates renal function in both animal...
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A Rutgers study finds people use 100+ chemicals daily through personal care products, some linked to cancer & hormone disruption. The good news? Safer choices = lower exposure. Learn how to reduce your risk:
rutgers.edu
A Rutgers study reveals average consumers are exposed to hundreds of chemicals daily, but awareness can lead to safer choices.
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#Taurine as a potential #prophylactic or #therapeutic agent to reduce symptomatic #malaria
https://t.co/NpmjkD0XI5
biorxiv.org
The prolonged dry season in malaria-endemic regions of sub-Saharan Africa can be divided into periods of high and low transmission. The majority of symptomatic malaria cases are restricted to the...
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#Nonuniversality of #inflammaging across #human populations. Wonderful work from Alan Cohen @ColumbiaAging
nature.com
Nature Aging - Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in...
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Long road from #animal research to #humans. #Taurine was first noted as beneficial for stroke and #cardiovascular diseases prevention in stroke-prone spontaneously #hypertensiverats. Okamoto K et al., Jpn Circ J. 1963, 27: 282-293. For further read:
jbiomedsci.biomedcentral.com
Taurine (T) was first noted as beneficial for stroke and cardiovascular diseases (CVD) prevention in genetic rat models, stroke-prone spontaneously hypertensive rats (SHRSP). The preventive mechani...
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#Taurine ameliorates #blood pressure and #vascular function in patients with type 2 #diabetes: Randomized, double-blind, placebo-controlled clinical trial. https://t.co/zQJkMAaReO
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For further read please see:
A reccent important study in the area of taurine biology by De Cabo's group provides new insight into changes in blood taurine levels in humans. In response to requests and tags I thought I will provide my point of view. @NirBarzilaiMD @davidasinclair @EricTopol @mkaeberlein
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Nice to see some media outlets stay with available scientific evidences when writing news articles.
verywellhealth.com
Taurine has been lauded as a promising way to slow down the aging process, but is this supplement really all it's cracked up to be?
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For further details see:
science.org
Taurine supplementation extends healthy lifespan in worms, rodents, and non-human primates.
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These results are consistent with taurine's role in senescence. We showed that taurine deficiency increases, and taurine supplementation in aged mice decreases, abundance of senescent cells. Taurine reduced accumulation of senescent cells in telomerase deficient zebra fishes.
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Low intracellular levels of #taurine is a common metabolic feature of several #senescence induction conditions (#Etoposide, #irradiation, #cell passage, #hydroxyurea)—Can it be a new marker for senscence? is taurine a #senolytic, #senomorphic or both? https://t.co/HgGHbdBgdl
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#Aging leads to depletion of #taurine in the mouse somatosensory cortex and taurine supplementation mitigates aging-related plasticity #decline. https://t.co/Ve2rfRZ7F2
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Tissue depletion of #taurine accelerates skeletal muscle #senescence and leads to early death in mice. https://t.co/AQrjQVXryp
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Structural basis of #taurine regulation of #aging hallmarks and cellular #senescence through its transporter. This work offers new avenues for developing #interventions to combat cellular aging. https://t.co/VUkKKD3Nqf
https://t.co/Mamled0EY9
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With research papers becoming increasingly free to read and use, understanding #OpenAccess licenses is key.
science.org
With research papers becoming increasingly free to read and use, understanding open-access licenses is key
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However, taurine blood levels are highly variable in adults and thus at the present time taurine cannot be used a biomarker to predict health or aging.
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In summary, taurine deficiency accelerates the pace of aging because if you supplement animals (worms, mice, monkeys) they live longer and healthier, and conversely if you make animals taurine-deficient they have poor health and have 40% shorter lifespan.
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