Vasilis Samelis
@VSamelis
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PhD student at The Francis Crick Institute, Wack lab 👨🏻🔬
Joined October 2012
Explore the world of Shigella infections with our latest review! From historical challenges to recent breakthroughs, we delve into the story of animal models in Shigellosis research 🐭🐰🐵🐹🐟 Thank you @COdendall for writing it with me! https://t.co/ivA0eWlI0G
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We each do our best to reduce our environmental impact at home and in the workplace, but meanwhile the government approves a new oilfield. How can this possibly be justified to meet climate targets?! Appalling leadership. https://t.co/vdwLG4lzeH
#StopRosebank
action.greenpeace.org.uk
Big Oil is fueling the climate crisis and leaving us to pay the price - Sign the Polluters Pay Pact.
The Tories’ huge new oilfield is a moral obscenity – but Rosebank can still be stopped | Caroline Lucas | The Guardian
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❗️BREAKING❗️ ‼️new class of interferons‼️ 🏃🏽♂️The Sprinter-ferons🏃🏽♀️ 5 family members identified! Fighting cancer but also very much engaged in host-pathogen interactions! @BenWiggins_093 @CIliakis @kfibu @VSamelis Get the scoop?! @CellCellPress @ScienceMagazine @Nature
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https://t.co/gXq31Jww2O This month, the Sprinter-ferons (@BenWiggins_093 , @CIliakis , @kfibu , @sandpiper_89 and I) are running 60 miles (~96km) to help raise money for Cancer Research UK! Visit the link to donate!
fundraise.cancerresearchuk.org
Cancer is happening right now, which is why we're fundraising right now for Cancer Research UK. There’s no time to lose! Donate today and help bring forward the day when all cancers are cured....
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Influenza-induced lasting changes to lung immunity: Emergence of reactive bone marrow monocyte-derived AMs or training of embryonically-derived AMs? Check out our discussion with the Yao lab on the identification and distinction of these phenomena here! https://t.co/HiXDLOIOeR
nature.com
Nature Immunology - The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function
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I'm very happy to share our work, which shows the importance of aryl hydrocarbon receptor signalling in lung endothelial cells to promote tissue tolerance and protection against respiratory virus infection.
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I am delighted to announce our manuscript on aryl hydrocarbon receptor (AHR) ligand sensing by gut endothelial cells is now out in @Nature! This has been a lot of collective hard work over the last 3 years, and I am proud to see this work across the line!
nature.com
Nature - Single-cell transcriptomics and in vivo challenge models establish a key role for the aryl hydrocarbon receptor in regulating the function of enteric endothelial cells in response to...
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Delighted to share our latest work on the molecular signals that drive steady-state and emergency bone marrow exit of #DendriticCell progenitors, led by @MarianaPdCosta, out now in @CellReports ! A 🧵... (1/x) https://t.co/Xj0qsvXYZp
cell.com
Pereira da Costa et al. identify retention and dispersal signals from CXCR4 and CCR2, respectively, as regulators of the ability of dendritic cell progenitors, pre-cDCs, to leave the bone marrow....
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💥The Minutti lab is recruiting a #postdoc and a research assistant @Neuro_CF to study dendritic cell #DC function and development in infection🦠🪱 and cancer If you are interested in #Immunology, apply here: https://t.co/8uXCjsdMd8
https://t.co/lIDXmZUUYB
euraxess.ec.europa.eu
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.
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How is the network of #DendriticCells in tissues maintained and expanded during inflammation? Very happy and proud to share our work identifying the molecular cues driving pre-cDC bone marrow exit during virus infection 🦠🫁 @CellReports @ReiseSousaLab
https://t.co/0FUOZ0PXFI
cell.com
Pereira da Costa et al. identify retention and dispersal signals from CXCR4 and CCR2, respectively, as regulators of the ability of dendritic cell progenitors, pre-cDCs, to leave the bone marrow....
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And it is out! Fantastic work from @lopix81. MAITs, type I IFN and bacterial infection… check it out! https://t.co/TlWbHxosL9
@JExpMed Thanks to our collaborators and funders @josebengoechea @BBSRC @TheCrick @KCLImmunoMicro @KCL_CIBCI
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Latest from the Lab @TheCrick. The transition from IgM to affinity-matured IgG #antibodies is vital for effective humoral immunity. @LZhang1807 identified a unique transcriptional mechanism required for IgG1+ B cell positive selection in #germinalcenters
https://t.co/tEwn88ENbH
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How are antigens retained in germinal centres after immunisation? Our paper is out in @NatImmunol. We show that antigens centralise on the FDC network concomitantly with the formation of the GC. https://t.co/Enj7WqEwTB
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Andreas Wack and his team have figured out how the ability for cells lining the lungs to become specialised, and thus their ability to help repair the lungs after injury or infection, is dependent on the specific nutrients they use https://t.co/Xz3n23H6cZ
crick.ac.uk
Scientists at the Francis Crick Institute have uncovered how cells lining the lung airways change their metabolism, and how this process is key to helping the lungs heal after infection or damage.
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Excited to share our review for the @theNCI Ras Initiative on the rationale, progress and challenges of combining KRAS inhibitors with immunotherapy in lung cancer!
frederick.cancer.gov
The National Cancer Institute RAS Initiative endeavors to better understand the RAS oncogene and discover its vulnerabilities to treat RAS-related cancers. About one-third of all human cancers are...
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Paper accepted! A new function for CD1d controlling lipid metabolism in macrophages. Check it out! Excellent work from Phil and @lauren_v_evans and thanks to collaborators @cardiffuni
@KCL_CIBCI @KCLImmunoMicro @TheCrick @NatureComms @BBSRC
https://t.co/mDXiDPBCqB
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Excited to share our latest work with @sdecarne where we developed a novel preclinical immunogenic model of KRAS-mutant lung cancer which can be used for the evaluation of targeted and immunotherapy combinations. Out now in @CR_AACR ✨
aacrjournals.org
This study develops a mouse model of immunogenic KRAS-mutant lung cancer to facilitate the investigation of optimal combinations of targeted therapies with immunotherapies.
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Our work with @philipeast and @JulianDownward on #KRAS oncogenic signalling and resistance to therapy in lung adenocarcinoma (#LUAD) is out in @NatureComms! Tweetorial 🧵 Please share 🙂 https://t.co/oZAIAcOukO
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Our study showing that severe COVID-19 in the aged organism is caused by an age-dependently impaired type I and type II interferon response, is now available in @JExpMed! Congrats and thanks to all collaborators, especially to first author Julius Beer! @MartinSchwemmle
Advanced age is the most critical risk factor for severe #COVID19. Beer, @MartinSchwemmle, @sandpiper_89 et al demonstrate that the age-dependent exacerbation of disease is driven by a diminished innate & adaptive immune response https://t.co/jDcxnMWcL9
@Uniklinik_Fr @UniFreiburg
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