KorolchukLab
@VIKorolchuk
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Cell biology lab, molecular mechanisms of nutrient sensing and autophagy, ageing and age-related disease 🇺🇦
Newcastle University, UK
Joined May 2011
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Pinned Tweet
For an academic there’s nothing more meaningless and wasteful than writing grants. Whomever claims to like the opportunity to spend months writing deliverables and risk mitigations should be shamed as a liar and a cheat. The right question should be sufficient for funding.
3
9
39
Today I have to give two undergrad lectures while my home town and many cities in
#Ukraine
are being bombed, not even sure how to begin processing it.
38
28
614
Our paper
#Autophagy
promotes cell survival by maintaining
#NAD
levels is not published in
@Dev_Cell
.
Congratulations to all the authors and a big Thanks to the Editors and Reviewers!
Also on the cover thanks to an amazing design by
@HSalmonowicz
!
41
107
497
I have a 2-year fully funded postdoc position and looking for an enthusiastic person with an expertise in molecular cell biology, confocal microscopy, biochemistry and an interest in autophagy.
Please RT.
Interested candidates, email me your CV and we’ll take it from there.
6
296
285
The next paper from our lab is out in
@embojournal
!
We show that
#autophagy
machinery evolved in humans to sense
#ROS
and efficiently remove damaged
#mitochondria
.
Congrats to the team and a massive thanks to Collaborators, Reviewers and the Editor!
15
62
247
Our pre-print "mTORC1 activity is supported by spatial association with focal adhesions" is now published in
@JCellBiol
!
Congratulation to to all the authors!
Out latest preprint clearly demonstrates that
#mTOR
and
#lysosomes
are very pretty under the microscope! A big thank you to our amazing collaborators
@adambyron
, Ponimaskin Lab,
@RalitsaMadsen
and
@bernimcarroll
!
4
22
139
20
41
211
Our first preprint from the lab is out:
#Autophagy
promotes cell and organismal survival by maintaining
#NAD
pools. Six years of fun science, many dead ends and breakthroughs, fantastic collaborations all finally boiled down to a four-figure paper!
4
41
163
Our paper is on the cover of the new
@embojournal
issue!
A huge thank you to
@HSalmonowicz
for an amazing design illustrating damaged mitochondria being removed by redox-sensitive mitophagy receptors!
9
27
160
Our saga about an intimate relationship between
#autophagy
and
#NAD
metabolism co-produced with
@SarkarSovan
lab continues and I present you the next chapter, this time showing an essential role of these processes in human ESC-derived
#neurons
. Enjoy!
8
43
156
mTOR substrate phosphorylation in growth control
1
29
147
Out latest preprint clearly demonstrates that
#mTOR
and
#lysosomes
are very pretty under the microscope! A big thank you to our amazing collaborators
@adambyron
, Ponimaskin Lab,
@RalitsaMadsen
and
@bernimcarroll
!
4
22
139
Our review paper discussing the two pillars of longevity,
#autophagy
and
#NAD
, is now out in
@TrendsCellBio
!
Thank you to the Editor, Reviewers, and congrats on the great team work
@niall_wilson
@ringa_AR
@SarkarSovan
et al!
6
37
139
A new hypothesis paper from our lab proposing a concept very close to our heart: selective
#autophagy
evolved in humans as a mechanism of oxidative stress response promoting
#longevity
Congrats to the authors!
Open access for everyone to dive in!
2
29
131
From a new mechanism of
#Autophagy
decline with ageing to the evidence of
#mTOR
activation in
#focal
#adhesions
in vivo, there is lots of exciting stuff in this week’s
@Biomednew
report. Don’t miss it!
1
32
125
It’s shameful that the UK still requires visas for women and children running from war in
#Ukraine
. I have received many requests from friends fighting back home and asking to house their families, yet I’m powerless until they have been granted entry.
@UKhomeoffice
, act now!
4
28
123
#mTOR
and
#Autophagy
papers from last week, covering the role of these processes in everything from neuronal function to planarian regeneration, enjoy thanks to
@BiomedNew
!
0
19
119
Mitochondrial-derived vesicles in metabolism, disease, and aging: Cell Metabolism
0
32
112
Finally an explanation for an increased lysosomal content in
#senescent
cells which is the basis for decades-old Sen-B-Gal assay. Great work Carroll lab! 👏
TFEB‐dependent lysosome biogenesis is required for senescence
0
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111
Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration | Science Advances
0
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106
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes | Nature Cell Biology
0
22
101
The “civilised” world should be ashamed of itself for ignoring what is happening in
#Ukraine
right now. But not standing up to a bully now will just make him stronger, we’ll all suffer at the end.
6
7
96
#Autophagy
and
#mTOR
papers from last week! Looks like the field is focussing on
#mitophagy
at the moment, perhaps unsurprisingly considering how cool the topic is. Enjoy browsing thanks to
@Biomednew
!
2
22
89
Autophagy and autophagy-related pathways in cancer | Nature Reviews Molecular Cell Biology
0
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84
We are pleased to announce that the next Autophagy UK Network meeting will take place on 19-20th June 2023 at the University of Birmingham! Organised by
@SarkarSovan
and
@VIKorolchuk
, lots of slots for selected talks and a DJ party. Apply by 22 April 👇👇
2
37
84
Great talk by
@Juanaloca2002
on the mechanisms of Batten’s disease, linking lysosomal and mitochondrial dysfunction
@autophagyuk
#WAutophagy
2
7
80
#Autophagy
and
#mTOR
in
#ageing
and autophagy as a mechanism of oxidative stress response are among the topics of this week’s curated selection of papers from
@BiomedNew
, enjoy!
0
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79
#Autophagy
and
#mTOR
papers from last week, happy reading and self-eating! Thanks to
@BiomedNew
for pre-selection!
1
16
73
Catching up with
#autophagy
and
#mTOR
literature after six weeks of war in my home country 🇺🇦, great science gives hope for the future!
1
19
72
A CRISPR view on autophagy
0
13
72
Over these horrible past eight days I’ve noticed how much more emphatic women are compared to men. If all the rulers in the world were women there would be no dictators, no wars. It’s as simple as that. Can we make this a law?
#SupportUkraine
8
4
72
Macroautophagy in quiescent and senescent cells: a pathway to longevity?
1
17
71
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome | Nature Cell Biology
1
10
70
Phospholipid imbalance impairs autophagosome completion
1
18
67
#Autophagy
and
#mTOR
papers last week, plenty of interesting stuff to dive into! Thanks to
@BiomedNew
for pre-selection!
0
10
69
Greateful for this opportunity to work with the
@vita_dao
community and
@Molecule_to
and pursue our joint aim to identify new interventions for healthy ageing, exciting times ahead!
The Korolchuk Lab will be the 2nd research organisation to fund their longevity research via IP-NFT. This historic moment needs to be celebrated properly! 🎉
Join VitaDAO's IP-NFT Transfer Ceremony with
@Molecule_to
&
@VIKorolchuk
⏲️Dec 23 4pm CET
▶️
0
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7
7
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Cool new
#autophagy
study from the lab of David Rubinsztein, phagophore is a hand-like structure grasping substrates, needs to be seen to believe!
Mammalian autophagosomes form from finger-like phagophores
0
20
68
The last non-sciency tweet today if I may, it’s not OK to bomb neighbouring countries, then send tanks and kill thousands to occupy them? Also, can we stop pretending that nothing is happening and business is as usual, because once Kiev falls who’s capital is next?
2
8
69
Happy New Year to all
#Autophagy
and
#mTOR
fans! Here is the first selection of papers from 2023, enjoy!
Let this day be the start of new happiness, success and peace around the world!
0
15
69
A long awaited (since morning) selection of latest papers on
#autophagy
and
#mTOR
. Don’t fight over it, one reader at the time 🧐
0
16
60
Just wrote to the local MP, if you feel the same please feel free to speak up and put pressure on your governments wherever you are. Last non-sciency tweet today, promise.
2
16
66
A new
#PhD
opportunity in biochemistry and cell biology of an
#autophagy
protein p62 under joint supervision of
@TheYueLab
and
@VIKorolchuk
. Application through the link below👇
2
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65
Non-canonical mTORC1 signaling at the lysosome
0
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63
We are grateful to Reviewers for their constructive comments
2
8
61
Mitochondrial DNA quality control in the female germline requires a unique programmed mitophagy
0
14
61
It’s been a great first day of the
@autophagyUK
network meeting, culminated with a beautiful keynote lecture by
@Carmine21678
Next is the keynote dance by
@Jon_D_Lane
#AtgUK23
3
4
62
#Autophagy
and
#mTOR
papers from last week, my Birthday edition of
@Bims_BiomedNews
report, 49 papers for every year of staying alive so far, and naturally starting with our paper as an extra present. Enjoy! 🥳
12
17
62
The authors should demonstrate the relevance of their findings using human models.
Rebuttal:
2
10
61
I’m somewhere between bargaining and depression but definitely haven’t yet reached acceptance. Please don’t accept, deny and speak up, we are supposed to be living in a democracy, don’t let your government to turn a blind eye. Support
#Ukraine
by demanding to ostracise Russia!
2
11
59
TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
1
18
60
#Autophagy
and
#mTOR
papers from last week highlight importance of these processes in a wide range of models and diseases, lots of interesting stuff to read on a quiet Sunday. Enjoy, thanks to
@BiomedNew
!
1
17
59
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
0
14
60
#Autophagy
and
#mTOR
papers from last week, the field was busy with 70 brand new reports to browse through, enjoy thanks to
@BiomedNew
!
0
12
56
Latest papers on
#autophagy
and
#mTOR
, the field is going from strength to strength and there’s lots of exciting stuff happening, enjoy thanks to
@BiomedNew
!
1
16
55
#Autophagy
and
#mTOR
papers from last week, plenty of reasons to eat yourself healthy, enjoy! Thanks to
@BiomedNew
for keeping us informed!
1
13
56
1
17
55
Our latest review on
#lipids
,
#lysosomes
,
#mitochondria
,
#autophagy
and Lewy body formation is out in Acta Neuropathologica
0
14
56
mTORC1 activity negatively regulates human hair follicle growth and pigmentation | EMBO reports
2
16
54
Looks like quite a few people have unfollowed me recently, presumably coinciding with tweets in support of 🇺🇦 in its struggle for survival. Must be those who think that science is beyond politics, or worse still those defending the aggression, so happily unfollowed back 👋🏼
1
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55
#Autophagy
and
#mTOR
papers have taken over several journals last week, a very rich selection that can’t be missed! 👇🏼👇🏼👇🏼
0
18
54
An exciting new paper in
@CellCellPress
describing a novel player in
#mTOR
#lysosome
signalling. Thrilled to be a part of this collaborative effort led by
@ThedieckLab
and
@LabOpitz
. Congratulations to all the authors!
1
16
53
Amazing work from
@DemetriadesLab
, what an exciting development for the
#mTOR
field! Congrats to the authors!
Looking forward to seeing how lysosome-independent nutrient sensing concept develops and links with other mTOR locations like plasma membrane!
2
12
53
Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence | Nature Cell Biology
0
13
53
Poster and short talk winners of the 2022
@autophagyuk
meeting!
Thank you and congratulations
@NezisLab
for organising an amazing conference!
2
11
52
A new
#PhD
position is available in my lab in collaboration with
@MPapamichos
to work on
#autophagy
and
#metabolism
, we are looking for exceptional candidates to be competitive for the selection committee, please apply via the link below 👇🏼
0
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50
#Autophagy
and
#mTOR
literature published last week, if you are interested in nutrient sensing and response pathways it's worth having a look!
0
11
50
Parkin coordinates mitochondrial lipid remodeling to execute mitophagy
1
12
49
Lots of excellent papers on
#autophagy
and
#mTOR
this week, enjoy! And as always, thanks to
@BiomedNew
for the selection!
1
14
49
#Autophagy
and
#mTOR
papers from last week, lots of goodies as always, don’t miss this exciting selection!
1
14
49
Happy to report the first vaccination, even if it gives away my advanced age
4
0
50
Latest reports on
#autophagy
and
#mTOR
, my personal favourite is the comparison between Mt-Keima and mito-QC sensitivity in PINK-PRKN mitophagy. Enjoy!
2
15
49
Latest collection of papers on
#autophagy
and
#mTOR
, there’s lots of interesting stuff going on, have a look!
0
14
47
Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
0
15
49
Our next book in Biochemistry and Cell Biology of
#Ageing
series just published by
@SpringerNature
, check it out!
1
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48