Farnaby Group
@FarnabyLab
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Farnaby lab is on twitter now! We work on discovery of #molecularglues and #PROTACs to better understand and address CNS diseases. We are based in @UoDCeTPD and part of @UoDLifeSciences at @dundeeuni.
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Highly recommend this post doc opportunity in the Mehta lab @mrcppu.
Postdocs invited to apply to join an exciting project involving kinome-wide CRISPR screening in iPSC-derived motor neurons co-cultured with microglia to uncover novel targets for C9ORF72 motor neuron disease. #MND #ALS #CRISPR #neuron #postdoc .Visit:.
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RT @alessiociulli: Excited to share our discovery of ACBI4: VHL PROTAC degrader of KRAS(on) mutant e.g. G12R. High ternary-complex cooperat….
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Check out the latest edition of the CeTPD journal club.
The April–May CeTPD Journal Club is out! Catch up on cool new #TPD papers. Thanks Alejandro, Giulia, Mhairi & Ryan! @UoDLifeSciences .
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RT @mrcppu: Day 1 of the UK #Autophagy and #Proteostasis Conference at @UoDLifeSciences with opening remarks from Prof Ian Ganley. https://….
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RT @alessiociulli: A privilege to be a part of @CancerGrand Team-KOODAC that is called out in this nice @Nature Feature by Ken Garber as a….
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RT @MariaRRios3: I am delighted to share the story that we've been crafting at the @UoDCeTPD in collaboration with @Tocris @biotechne for….
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Special mentions to @nurkocaturk and @Holmqvist89 for driving this project, key collaborators Calum Sutherland and Kevin Read and their groups in Dundee and our awesome collaborators and supporters at @biotechne and @UoDCeTPD.
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A key learning: modest brain penetration combined with rapid on-target degradation kinetics was sufficient for activity in brain, highlighting opportunities for those who want to degrade proteins in the CNS and perhaps cautions for those who don’t. 6/7.
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Further profiling validated our best hits as cellular and in vivo quality degrader probes that we hope will help researchers further understand this target implicated in several neurodegenerative disease related pathways. 5/7.
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Once we had the assay, method and linker toolbox established we synthesised, screened and analysed data, from scratch, in 5 days, to identify potential hits. 4/7.
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We used a new approach we called ‘orthogonally reactive linker screening’, to vary all elements of a bifunctional via multi-step synthesis in a well: E3 binder, POI binder, linker and conjugation chemistry. We did this in context of discovering GSK3 degraders. 3/7.
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If you like TPD, direct-to-biology approaches, new chemical probe methods, induced proximity or Central Nervous System drug discovery then this is for you! 2/7.
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Excited to share the Farnaby Group’s first pre-print, detailing our approach to plate-based bifunctional chemical probe discovery, identifying a brain active PROTAC directly from a single screen. 1/7.
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RT @LabGanley: Registration for the joint Autophagy UK & Proteostasis UK meeting is now open. Going to be a great meeting and we look forwa….
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RT @UoDCeTPD: A team from CeTPD have released an excellent review that examines patents involving VHL ligand and PROTAC modifications from….
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We have a fully funded PhD position in the lab! Looking forward to finding excellent talents to work with! Deadline is 17th Jan! Check out the link for more information!
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Couple more days left to apply for our PhD studentship with Promega. .
@FarnabyLab, @promegauk have teamed up on a PhD studentship with co-supervision from Prof. Kevin Read of @DDU_Dundee. If you're interested in targeted protein degradation and would like to do a PhD at the world class @UoDCeTPD then take a look below.
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RT @PromegaChris: @FarnabyLab, @promegauk have teamed up on a PhD studentship with co-supervision from Prof. Kevin Read of @DDU_Dundee. If….
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We are super excited to be part of this new partnership between @UoDCeTPD and @BioAscent , also supported by @innovateuk developing novel methods for high-throughput degrader synthesis and screening.
⭐️The KTP between @BioAscent and @dundeeuni is aiming to foster #innovation that will transform the drug development landscape. @IUK_KTP @innovateuk @IUK_Connect @UoDRIS.
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