laboute thibaut
@ThibautLaboute
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orphan GPCR, pharmacology, nanobodies postdoctoral associate at @scrippsresearch
Joined September 2012
RT @KLabGPCR: We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It….
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Interested in orphan GPCR signaling? 🧠✨.Nanobody development? 🚀.You want to know more about mGlyR (AKA GPR158) ? 🔬.Just stop by my poster (038) this morning at #FENS2024 ! @KLabGPCR @iBrain_Inserm
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RT @UngDevinaC: Let’s meet us this afternoon: #270 on FUNCTIONAL.CHARACTERIZATION OF DPYSL5 .GENE VARIANTS INVOLVED IN.NEURODEVELOPMENTAL.D….
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Voting has begun ! I need everyone : vote for me ! Spread the word ! 😊 .#promega.#prixjeunechercheur2023
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Incredible amount of work for this must read paper! Profiling hundreds of GPCR first and second coupling with an assay using natives G alpha is groundbreaking. A Reference in GPCR field ! .Congrats @KLabGPCR & Ikuo Masuho!.
Our systematic investigation of G protein coupling profiles of 100+ #GPCRs driven by the one and only Ikuo Masuho is out after ~10 years of work. We see many interesting patterns with the help of AI. Check it out- there is a useful reference table.
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Very excited to share this great discovery ! 🎉 At @KLabGPCR we finally found the metabotropic receptor for glycine in the brain! Amazing work of @_stezucca_ and @Dipak_P_tsri in collaboration with @ForliLab.
Happy to report that we found what we believe the first ever #GPCR for neurotransmitter glycine. It is an unusual receptor - an orphan GPR158 which couples to RGS proteins instead of G proteins. Thus it is also the first ligand-regulated RGS! Check it out.
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Can’t wait to see this amazing discovery out! Exciting team work!.
Such a wonderful start of the day! Hang on as we are about to tell a story about #GPCR for neurotransmitter glycine. Happy Friday everybody! Work of the incredible scientist @ThibautLaboute.
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RT @KLabGPCR: Our paper is out today @NatureNeuro. We find a new player controlling mu-opioid receptor trafficking via effects on cholester….
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RT @KLabGPCR: Our paper by @subhimarwari and @CodyKowalski is out today in @BrJPharmacol. We find that pharmacological blockade of Gq/11 s….
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Are you interested in neuronal orphan GPCR? Stop by at the S02-362 #FENS2022. I can’t wait to have interning discussions!.
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RT @Structure_CP: #Llamanade! Open-source software from @Proteomics_Shi and colleagues @CarnegieMellon and @PittTweet that facilitates rati….
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RT @scrippsresearch: Prof. Kirill Martemyanov’s lab have determined the near-atomic-scale structure of an unusual brain-cell receptor (GPR1….
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Wow ! The orphan GPCR GPR158's structure is out ! Congratulation to everybody involved ! Special congrats to @Dipak_P_tsri ! I'm proud to work with you guys at @KLabGPCR lab !.
Can a #GPCR structure still surprise you? Happy to present #CryoEM structure of an orphan receptor GPR158. Couples to RGS instead of G proteins. Features an extracellular Cache domain for ligand binding.Forms a unique tight dimer stapled by phospholipids
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RT @EmmanuelMacron: Quelle course et quelle année de @FabioQ20 ! Bravo à lui, il devient le premier Français à obtenir le titre de champion….
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RT @scrippsresearch: Congratulations to Scripps Research’s Ardem Patapoutian, who has been awarded the 2021 #NobelPrize for Physiology or M….
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