Santos Franco
@TheFrancoLab
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I used to do science. I still do, but I used to, too. // Assoc. Prof. @ CU-Anschutz // New Mexican // Chicano // he/him
Denver, CO
Joined December 2017
My two new year’s resolutions, found on these boxes at H Mart.
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BRAIN EVODEVO ALERT! So thrilled to share our newest articles about brain evolution, published by @ScienceMagazine! Briefly, we have found that pallial circuits are formed by different developmental programs and comprise different neurons. Not all brains are the same!
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Excited to share our work published this week! Led by myself and world class co-first @gdfnunes working in the @EthanHughesLab in collaboration with Dan Denman: https://t.co/HH9RKGY4ar. A short 🧵
nature.com
Nature Communications - Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination...
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Check our new results showing that loss of Elongator activity impairs the maturation tempo of ependymal cells bioRxiv
biorxiv.org
Conditional deletion of Elp3 in the mouse forebrain leads to microcephaly at birth. In this study, we demonstrate that these mice also develop postnatal hydrocephalus, associated with an enlargement...
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I need a Spotify Wrapped but for articles I never read this year, ranked by how many weeks I had the tab open without reading it.
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With all the amazing glia researchers on campus we recently expanded our “Myelin Meeting” to a “Glia Gathering”. Keep an eye out here for all the cool #glia science 🧪 coming out from our groups! You should be seeing some preprints from several of us very soon…
The #GliaGathering @CUAnschutz growing! Excited to hear one of the "OGs" @TheFrancoLab talk today about glia in brain development.
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🚨 The lab's first preprint is out! Led by rockstar graduate student @LaurynHigginson, we present the first cell-specific transcriptome analysis of the RNA exosome, a conserved RNase, in a fully developed Drosophila brain! #RNABiology #Neuroscience 🪰🧠 🧵
biorxiv.org
Intracellular ribonucleases (RNases) are essential in all aspects of RNA metabolism, including maintaining accurate RNA levels. Inherited mutations in genes encoding ubiquitous RNases are associated...
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It begins today! Excited to start welcoming over 5,500 attendees to #2024NDiSTEM, kicking off a week of learning, mentorship, and community building. #Science #Culture #Community Learn more about @SACNAS in this recent piece shared with @Divinaction: https://t.co/RoEl5PXwI6
mydigitalpublication.com
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I am thrilled and honored to receive this Javits Award from @NIH_NINDS, and incredibly grateful to all past and present members of my lab, as well as my mentors and colleagues in the field! @DukeMGM @DukeNeuro @DukeCellBiology #radialglia
Debra Silver, PhD, has been honored with the 2024 Javits Award from @NIH for her groundbreaking work on intellectual disability and autism. Her research on radial glia cells continues to illuminate the complexities of neurological disorders. @TheSilverLab
https://t.co/OaaUM7ukAj
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Gonçalo @GoCasteloBranco and I are so excited to share our work on mapping spatial dynamics of brain development & neuroinflammation! 🤩🤩🤩Kudos to amazing postdocs Di Zhang and Leslie Kirby! 👍👍👍 @YaleEngineering @karolinskainst
biorxiv.org
The ability to spatially map multiple layers of the omics information over different time points allows for exploring the mechanisms driving brain development, differentiation, arealization, and...
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I am excited to share our most recent story led by our fantastic postdoc Lucas Serdar. How is steady state gene expression of the developing cerebral cortex controlled? The answer lies beyond transcription.... https://t.co/qVpWBKF8Pr 1/
biorxiv.org
RNA expression levels are controlled by the complementary processes of synthesis and degradation. Although mis-regulation of RNA turnover is linked to neurodevelopmental disorders, how it contributes...
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I am super excited to share our paper published today in @NatureComms! Have you heard about heart-brain axis? Here we asked why heart defects are prevalent in children with neurodevelopmental disorders, such as the rare KBG syndrome. https://t.co/cTXI2aEGly 1/9
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Very cool paper! Congrats @BorrellLab
Gene regulatory landscape of cerebral cortex folding | Science Advances
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Exciting news! We'll be re-opening our application cycle one last time for our final FIRST hire! We plan on opening this week (week of May 20) so keep an eye out and help spread the word! #academictwitter #academichiring #unmfirst #nihfirst
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Extremely excited to share our review on mature myelin dynamics out today! @EthanHughesLab and I discuss myelin remodeling and turnover, mechanisms and functional implications. I hope folks will enjoy diving into this fascinating emerging field with us! https://t.co/kb6RWAWFjM
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this might be the first time we’ve seen an I SHOULD’VE WON MVP revenge game from a guy who actually won the mvp lol
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I am very happy to share that our work demonstrating that without Sst-Inhibitory interneurons many L4 excitatory projecting neurons mature as callosal neurons is out. It was a great collaboration with @FelixFelxfel and G. Perea lab.
science.org
Timely maturation of early inhibition ensures the elimination of developmental S1L4 callosal axons and fine-tuned somatosensation.
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“There are 800,000 incarcerated workers in the US, and they do roughly $10 billion worth of work a year” Modern day slavery.
Inmates do billions of dollars of work for companies and governments each year. A landmark trafficking lawsuit alleges many are being kept in prison because the business is just too good. The suit says it seeks “to abolish a modern day form of slavery”
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Our paper is finally out in it's final form!
Online Now: The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics https://t.co/M8SDKeMgCJ
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