Cells live and interact in 3D tissues but pathology and spatial omics typically rely on 2D sections. Excited to share our latest efforts in @N_Rajewsky lab to generate a 3D, multimodal atlas of a human tumor!. Find out what we learned: video + 🧵!.🔗

Many thanks to whole @N_Rajewsky, our institutions @BIMSB_MDC @MDC_Berlin @Charite and personally to @BSIO_Berlin & Joachim-Herz-Stiftung for the support!!.

6/ That’s a wrap! The potential of ST to revolutionize clinical practice is huge, but we still have work to do to unlock its full impact. Stay tuned as the field evolves! 🚀.

5/ As large-scale clinical studies are urgently needed to link spatial biomarkers with patient outcomes, we discuss key considerations for the design of clinical ST projects from sample preservation and method choice to panel design and power analysis.

4/ Several challenges exist to their swift clincal translation: What is the ‘best’ ST method? How do we turn complex molecular data into meaningful insights for patient care? How do we integrate in clinical routines?

3/ In the clinic, spatial biomarkers and patient-specific molecular mechanisms identified by ST hold great potential to inform patient care and help the discovery of novel drug targets, as showcased in early preclinical studies

2/ With high-resolution ST we can study tissue organization in 2D and 3D virtual tissue blocks, analyzing the organization of cells in multicellular niches and identifying which receptor–ligand interactions orchestrate their function in situ.

1/ High-resolution ST omics work as molecular microscopes, digitalizing gene expression and tissue morphology at subcellular resolution. This enables the interactive exploration of millions of transcripts and their comparison with routine histology and pathologist annotations.

Check our review on the 'Challenges & Opportunities in Clinical Translation of High-Resolution Spatial Transcriptomics (ST)' now online ahead of publication!! .

#Spatialtranscriptomics is revolutionizing gene expression profiling at subcellular resolution!. 🔬These 'molecular microscopes' can unlock disease mechanisms & guide therapies. but how to bring ST to the clinic?. Our thoughts w @N_Rajewsky & @nu_karaiskos out @AnnualReviews🧵👇.

RT @danilexn: Our #OpenST paper is now online @CellCellPress!. Very cool updates ahead🧵⬇️. @L_Marie_Schott @_Elena….

RT @N_Rajewsky: i am so excited about our open source inexpensive, sub-cellular capture, do-it-yourself Open-ST that transforms tissues int….

RT @arturman_sl: We would like to thank everybody who showed up yesterday to the talks of @TMPentimalli and @danilexn for this meeting of B….

RT @ILegnini: 1/8 We are hiring!!! 🐣🐣🐣.Fully funded PhD position in my group!

RT @mfgrp: How to pick a problem. Today in @CellCellPress. 1/53.

RT @ggargiul_2020: How do cell states contribute to the aberrant homeostasis of a tumor tissue? We propose a functional classification as D….

RT @satijalab: Beautiful new work from @N_Rajewsky lab on DIY high-resolution and 3D spatial transcriptomics. Learn more at .

RT @danilexn: Join us on Friday, 3/29! . We will let you know more about Open-ST 😉.

RT @whitefishlab: Cells can switch phenotype states, but we've long wondered what triggers that switch. In @mrndhntr's new paper, she shows….

RT @ILegnini: I'm looking for an intern! 🐣.If you just finished your master or are about to and want to do a 6 months+ project working with….

RT @NatureProtocols: Our #FeaturedProtocol this week: #Lightsheet fluorescence #microscopy to analyse the spatial distribution of #immunece….