Taylor Thompson
@TJThomps
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Director of Lifestyle and Fitness | Exercise Physiologist | Longevity Researcher https://t.co/V8u49rhLTY
Joined September 2021
The physics cellar at @ARDD_Meeting changed my research trajectory into aging. I gave a short impromptu talk during the whiteboard session, which has been published. Thanks @MaxUnfried @UriAlonWeizmann Link 👇
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How do we up-regulate DNA repair mechanisms in humans? Is hormesis the only way?
Bowhead whales live 200+ years with low cancer risk. A new study discovered that it might have to do with their powerful DNA repair abilities. Most animals prevent cancer by detecting DNA damage and killing the cell (apoptosis) or stopping its growth (senescence). Bowhead
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Few understand this. The theory is that increased calcium turnover may pull calcium from the bones to support repeated muscle contraction. Lift weights skinny boys.
Running is high impact, but it’s NOT great at building bone density. Many people get this wrong because it’s counter intuitive. It’s one of the only examples where the body doesn’t directly adapt to the stresses placed on it. The bones stop “listening” to the repeated loading
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Aging is functional decline. Delaying functional decline in elite athletes might be a solution for aging research funding. Every extra year of elite performance generates millions of dollars.
On aging, diseases and fallacy of healthspan
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VO2 Max will change its name to just VO2 now.
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We need more time to work out what is going on. Aging is the weight in the wings.
"Brief is man’s life and small the nook of the Earth where he lives; brief, too, is the longest posthumous fame, buoyed only by a succession of poor human beings who will very soon die and who know little of themselves, much less of someone who died long ago." Marcus Aurelius
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This is an interesting concept. There may be something to the stress of exercise that causes goal orientation again to build muscles, increase vascularization, etc.
I am extremely perplexed why the concepts in this paper is not attracting a wider audience.
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If you or someone you know is interested in zone 2 training and metabolic health I highly recommend checking out my latest episode with Dr Inigo San Milan who has famously coached Tour de France Champion Tadej PogaÄŤar. In this episode we spend considerable time on understanding
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Just sold shovels during the biggest gold rush known to mankind
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Absolutely gorgeous! This is the kind of biological beauty responsible for setting the energy resistance (Ă©R) level in your mitochondria, enabling the transformation of food into the energy that powers your energetic self. ERP: https://t.co/3wr5GFoXe2
https://t.co/vsDGw7SLwX
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We still don’t have a proper theory of aging. That’s remarkable, given how far biology has come. Despite centuries of speculation and decades of data, there is still no unified, quantitative framework that explains how and why living systems age—and how we might stop it. What
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Maybe our energy systems are lazy and trend to the easiest available energy source. Fats are expensive, they cost lots of oxygen to use. Carbs are cheap. We might be willing to "spend" oxygen when carbs are running low. Maybe we should strive for this.
The Cross Over Point (COP) during exercise of increasing intensity has been recognized since the 1980s. It's often used to justify the doctrine that carbohydrate, muscle glycogen in particular, is the obligatory fuel for exercise of high intensity. We've recently identified the
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Be the steak you'd want to eat. 🥩
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Vigorous exercise is more valuable than we originally thought. New: 1 min Vig = 9.4 min Moderate Old: 1 min Vig = 2 min Mod Go hard.
New paper, health value of each minute of different physical activity intensities against 6 health outcomes. https://t.co/zXdmBzsBNM Pretty much the whole industry (incl. @Google Fit @Apple Fitness+) assume that 1 minute of vigorous activity = 2 minutes of moderate
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"Net muscle glycogen utilization is determined by muscle glycogen content at the start of exercise, even during hyperglycemia." This matters, but im not exactly sure how to fully integrate this into action. 1. How does the body know and set fuel substrate utilization rates?
Also persistently high muscle glycogen content = persistent fat burning. It's muscle glycogen content which directs what fuels you burn both at rest and during exercise. That's the way God/evolution designed us. https://t.co/toAi5eUtof
https://t.co/mJFMqiN7jw
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"We can assume that more than one of us here at the Stockholm Concert Hall has sometimes thought it might be desirable to once again be young, wild and maybe a little crazy – and perhaps be offered the opportunity to grow up another time and try a different path than the one we
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