Peter Fedichev
@fedichev
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A physicist in drug discovery land. On a mission to significantly extend human lifespan. Founder of Gero (@hacking_aging)
Singapore
Joined April 2009
BREAKING: Gero Signs Potential Multi-Billion-$ Deal to Fuel Our Mission to Stop Aging -- A few years ago, my son, aged five at the time, asked what happened to the dinosaurs. After learning their sad story, he told me he wanted to fly to the Moon and defend Earth from falling
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We’re optimizing for safety, not discovery -- producing endless variations of the same drug. @fedichev explains how Pharma's risk aversion is dangerous for innovation.
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let's thank the concerned reader (@DrPatrickE) for a good question. z0 is the leading organism level stress response - in higher animal likely body composition/wound healing + components of innate immunity (aka inflammaging, see our https://t.co/UZtHASPJo1). The biological
@fedichev Hi Peter, I'm trying to get a better grasp on the meaning of the math in your preprint. Do you have an intuitive explanation of what z0 represents physiologically? Visualizing it with a simulation would go a long way. Also, how does your model explain lifespan scaling laws?
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You're asking and answering the question "why do we age?" — we're answering the question "how do we age?" (in the sense of what causes it on a mechanistic level in an individual). These are two very different questions. Your argument explains why aging might be beneficial for
@fedichev Isn't the "why living systems age" quite obvious? To make space for offspring with genetic variants to have a better chance adapting to an ever changing environment.
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We still don’t have a proper theory of aging. That’s remarkable, given how far biology has come. Despite centuries of speculation and decades of data, there is still no unified, quantitative framework that explains how and why living systems age—and how we might stop it. What
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The hackathon kicks off on October 7 (9 AM SF / 6 PM CET) with @DeryaTR_’s inspiring opening speech and the presentation of challenges. Join the army of good — now over 700 participants strong. ✨ Late registration is still open @ https://t.co/cxUITzVLjb!
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And another time soon
🔥Thrilled to spotlight our Featured Talk “Engineering the Path to Radical Life Extension”at The Scaling Summit during @token2049 Singapore! 🔗 https://t.co/PAFrDfxG3Q 🎙️Panelists: Peter Fedichev @fedichev , Co Founder, https://t.co/rozHdQRBEy
@hacking_aging 🕒Date and Time:
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ProtoBind-Diff generated molecules showed activity in enzymatic assays against a tough target — with hit rates apparently higher than among DEL hits tested off-DNA against the same target.
Designing small molecules to hit protein targets is the holy grail of drug discovery, but it’s a beast of a problem. For years, I’ve been obsessed with finding a practical way to crack it. Coming from a physics background, my gut always leaned toward modeling—think docking +
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Looking forward to talk about the @TTIScience approach to Life Extension at the Draper House in Singapore on 2nd of October. Thanks for hosting @infinitacity
@fedichev from Gero will continue and talk about their physics approach to longevity Join us: https://t.co/MMLPeUaUfd
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Join the hackathon - join the forces to solve this and other challenges! please repost!
Simon @ZdarovaAll is spearheading an Aging Theory challenge. His ML drug-discovery benchmark paper was accepted by @NeurIPSConf in 2023. Why is it of utmost importance? We still lack a strong, predictive aging theory, let us fix it together. Simon is one of the smartest and
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our preprint - https://t.co/KUlC9BIW3Z relevant work https://t.co/KlRSWzxuZs (first published on the arXiv in 2022)
agingcelljournal.org
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Our concerned reader, @LidskyPeter , makes a sharp point: "Classic models, damage accumulation, antagonistic pleiotropy, and disposable soma were found incompatible with rejuvenation, and we can prove it mathematically. As such, it is a bad piece of news for all of us if these
Is biological rejuvenation possible? Our recent preprint strives answering this question! Samir Aisin @Doc579923596039, my dad Boris Lidskii and me, investigated rejuvenation through the evolutionary lens. We found that the theoretical possibility of rejuvenation depends on
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In physics, area increases. In Twitter, maybe reach does too. Reposting to test the Hawking–@LidskyPeter theorem. For those who did not see my original post, please follow Peter's bait - the Second Law is a very interesting topic with lots of developments since its now-ancient
Cool reading on the entropic views on aging that I enjoy to fundamentally disagree with 😉.
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There’s a fascinating new paper on aging in planarians — these worms must divide to control accumulated damage. If they don’t, they start showing strange morphological features (like extra eyes). But we should remember: when we look at ‘immortal’ species, we’re only seeing
@fedichev Some organisms (e.g. flatworms) are basically ships of theseus, they can replace every cell in their bodies with a new one, and in theory can live indefinitely. So biology is capable of doing this in principle, it just decided not to do it for every organism.
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the paper: GW250114: Testing Hawking’s Area Law and the Kerr Nature of Black Holes https://t.co/IcwNLu9cyJ our preprint - https://t.co/EOHvBBH6TT another relevant work https://t.co/KlRSWzwX9U (first published on the arXiv in 2022) 2/2
agingcelljournal.org
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As you may know, we are writing a lot on relation between the Second Law of Thermodynamics and aging. The working hypothesis: a substantial part of what we call “biological age” in long-lived species (like humans) is nothing else but configurational entropy — the gradual
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🚀 Help spread the news, folks — registration is OPEN for the Agentic AI Against Aging (AAAA!) Hackathon! Gero @hackingaging and a bunch of other good folks are helping make it happen. We’re seeking adventurous developers (follow the link in the @OpenLongevity post below), jury
docs.google.com
LLMs — and especially agentic AI built on them — may be on the brink of real practical importance, with recent advances showing exponential growth in the complexity and duration of tasks they can...
Agentic AI vs Aging Hackathon Make an impact or shift your career into longevity with @RetroBio_, @hacking_aging, @nebiusai, @BioProtocol, @athena_DAO_, @vita_dao Turn two weeks into a job, collaboration, or company. Details 🧵👇
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@jangruber467 the preprint is at https://t.co/EOHvBBH6TT This is academic companion work to our previous https://t.co/vdYfQtQYuA 2/2
lifespan.io
For most of the history of human civilization, humanity expanded at an astonishing pace: faster than exponential, nearly hyperbolic. This trend was famously described in a 1960 paper by Heinz von...
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