Ivan Palaia
@IvnPla
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Lecturer in Biological Physics @KCL_Physics Previously @SaricLab @ISTAustria, @LMCB_UCL and @LPTMS 🦋 [email protected]
Vienna
Joined April 2019
Collagen-IV networks rule the #mechanics of our epithelia, but we know little about how they reshape. Our new preprint (with the 1st coarse-grained MD models of #collagen-IV!) shows how consuming energy during remodelling might make the difference: 📑 https://t.co/yTRbg87fRn 🧵
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Very happy to be a part of this story, connecting like-charge attraction, condensates and cell division 🤩 Check out @v_sorichetti's beautiful tweet-skeetorial! 📃 https://t.co/usF1E6q5jm
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Did you know there are more than bilayer #membranes in nature? Meet the #archaeal monolayer and its surprising mechanical properties! New #preprint! (1/7)
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Thus energy consumption unlocks forbidden parts of the mechanical phase space. Life might use this to tune tissue mechanics over time simply via enzyme concentration, without needing to modify the binding sites of collagen-IV molecules or the network structure.
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As bond remodelling mechanisms are unknown, we test 2 protocols: passive🧍♀️and active💃. With passive (equilibrium) remodelling, networks can only relax by compromising structural integrity. But with active (enzymatic) remodelling, relaxation is independent of connectivity✨
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We present 2 models, at different scales, both respecting collagen-IV molecular binding specificity. We use them to probe the self-assembly and mechanics of networks under high strain. Networks are viscoelastic and they break/remake bonds to relax stress.
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New PhD in the family!: Chris Vanhille Campos @vainhilla96 🍸🥂🧉🧁. Chris was our stellar ☄️💫 student with many passions — from bacterial division, to vesicle reshaping, condensates, self-assembly, guitar, icey Danube 🧊, braving bears, to making softies @ISTAustria happy 🍧
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The actin #cortex is attached to the #membrane via linking proteins. When these linkers get trapped in the cortex meshes, actin jams🚧, #contractility stops🛑 and cells polarise☄️Exciting collaboration (+ real fun!) with @diz_lab @TesoroRuben @SaricLab 📑 https://t.co/MsQac80tYM
New Preprint! How can cells polarize in the absence of a stimulus? We suggest a surprising biophysical mechanism, protein caging! We reveal how the complex mechanical interactions at the cell surface lead to symmetry breaking. https://t.co/BOwbtxlago
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First manuscript of the PhD in @biorxivpreprint ! Congrats to all co-authors and specially Srishti,@IvnPla ,@diz_lab ! I think we bring forward some cool concepts and questions to the field! (Slightly biased statement😜) Check it out and stay tuned for more things to come! 🤗
New Preprint! How can cells polarize in the absence of a stimulus? We suggest a surprising biophysical mechanism, protein caging! We reveal how the complex mechanical interactions at the cell surface lead to symmetry breaking. https://t.co/BOwbtxlago
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Did you know cell filaments love to treadmill? 🔄 They grow and shrink on opposite ends and burn energy doing it! But why? How does it drive self-organisation and bacterial division? Dive into our new publication ft. @SaricLab @nartimsoole @seamus_holden labs to find out! 🧫🔬🖥️
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Researchers at @ISTAustria have discovered a previously unknown mechanism of active matter #SelfOrganization, crucial for bacterial #CellDivision: Misaligned filaments spontaneously "die" to create a well-organized ring structure at the center of a dividing cell.
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Ready to hear our PIVOTING story? The preprint "Microtubule pivoting driven by spindle elongation rescues polar chromosomes to ensure faithful mitosis" led by @isabella__k and @Stimac_V is out. Here's a tweetorial for you! https://t.co/M1sJjNmaMm
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Discussing vesicles and microgravity with @LauraAlvarez_F: turns out it *is* rocket science after all! 🚀👩🚀 @SaricLab @miggral @b_maitane @sciFelixFrey
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We are very pleased to announce that Qian Chen and Andela Saric are the joint winners of the 2023 Soft Matter lectureship!
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Pompare il cv di articoli scientifici mediocri e pubblicare articoli ogni 5 giorni sono metodi comuni in diverse nazioni. E sta cominciando a creare molti dubbi. Il primo posto va all'Arabia Saudita. Al secondo posto di questo ranking? l'Italia......
nature.com
Nature - Some researchers publish a new paper every five days, on average. Data trackers suspect not all their manuscripts were produced through honest labour.
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2 beautiful days of our group retreat in the Alps. We hiked, we enjoyed silence ❄️, we enjoyed science, we cooked, we planned, we played, we 🛁 at 🌡️.
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