Sumera Perveen, PhD
@Sumera_Perveen
Followers
54
Following
1K
Media
0
Statuses
28
Scientist / Discoverer, University of Toronto @thesgconline
Toronto, Ontario
Joined September 2017
All participants to CACHE challenges are invited to join the overview paper. https://t.co/mvPwayM8kD CACHE#1 learnings: -Workflows were diverse. -Most top methods included some ML. -Hits were weak: lots of room for improvement. @thesgconline @consciencemeds #compchem
0
6
16
Announcing CACHE2 results! Crowdsourcing and conventional methods did as well as novel ML. Teams started from 4 fragments in the PDB. We tested their predictions and found double-digit µM hits. This is the state-of-the-art. @thesgconline @consciencemeds
https://t.co/Fbut1xK0yQ
0
24
88
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2 #Docking
https://t.co/m4ggXNTpoq
@CherylArrowsmi1 @HalabelianLab @Sumera_Perveen @mattschap @thesgconline
#JCIM Vol64 Issue13 #Bioinformatics
pubs.acs.org
We herewith applied a priori a generic hit identification method (POEM) for difficult targets of known three-dimensional structure, relying on the simple knowledge of physicochemical and topological...
1
15
32
All participants to CACHE #1 who agreed to be de-anonymized were invited to join the overview manuscript. The first of a long series to serve as a resource for future developments in virtual screening workflows. https://t.co/ZArbyTvIgi
@thesgconline @consciencemeds #compchem
1
15
57
CACHE symposium happening right now, alot of learning…
Take home messages from D3R and ongoing SAMPL challenges outlined by Michael Gilson.
0
0
0
Over the past 4 years, we applied machine learning to DEL screening data from 20 unprecedented targets. We found verified hits for half. Have a read!
A combination of experimental and computational methods identified ligands for WDR proteins. Learn how we used this resource in a hit-finding pilot, which involved DEL-ML and led to the discovery of first-in-class, drug-like ligands. https://t.co/n9MCtF4D3s
0
1
16
Read my latest #research on #HistonePosttransationalModifications, published with @wiley in @AdvancedScnce
https://t.co/EhWSfN5y5S
advanced.onlinelibrary.wiley.com
A range of light-responsive inorganic biomaterials, including carbon-based nanomaterials, gold nanoparticles, graphite carbon nitride, transition metal dichalcogenides, and up-conversion nanopartic...
A collaborative effort with @MSKCancerCenter has led to the development of a pair of complementary photo-arginine/δ-photo-lysine #probes to capture and explore the interactomes of Arg and Lys histone post-translational modifications. Read more:
0
0
6
Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intermolecular glue mechanism locking the protein in an inactive state: https://t.co/e8q9SAA9kV
@HalabelianLab @thesgconline
nature.com
Communications Biology - Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intramolecular glue mechanism locking the protein in an inactive state.
0
2
2
As Ramadan is near, I first and foremost seek anyone's forgiveness that I may have offended in person or online at any point. I pray Allah unites us all in that which is pleasing to Him. To my brothers and sisters who share the noble vocation of Dawah with whom there may have
239
2K
10K
Kicking off the SGC's 20th Anniversary Symposium with Dafydd Owen presenting the discovery and characterization of PAXLOVID, an orally bioavailable SARS-CoV-2 main protease inhibitor with in vitro pan-human coronavirus antiviral activity. #20yearsSGC
0
3
18
Computational chemistry postdoc position open in my group at @thesgconline, University of Toronto, co-supervised by John Irwin @chem4biology at UCSF to enumerate and screen new areas of the chemical space: https://t.co/wnNE0SBpJu Please re-tweet!
0
26
41
Very happy to be the editor for the first of the Ciulli Lab Journal Club! Check it out on what’s new in the #PROTAC field! #realtimechem #chemtwitter
The July edition of the Ciulli Lab Journal Club is now available, covering TPD and other exciting publications in June and July. Kudos to @jeff940317, Suzanne and Selma for putting together this fantastic issue! #TargetedProteinDegradation #OpenAccess #JournalClub @alessiociulli
0
2
18
Hey everyone, I’m Sumera Perveen a Postdoctoral fellow in Molecular Biophysics at University of Toronto. I’m here to connect with my colleagues and mentors. @thesgconline @MBPatUofT @UofT #medtwitter @UWaterloo @uwaterlooalumni @WaterlooBio
1
1
9
Cureus | Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Presenting as Migraine
0
1
1
12 yo girl with nodule on dorsal finger. Your diagnosis? WSI digital slide: https://t.co/2xwPkGEQBT. Answer & video: https://t.co/hRgIyxNdX4.
#Pathology #dermpath #dermatology #dermatologia #dermtwitter #BSTpath
1
13
29
More open access #COVID19 research available from SLAS Discovery. Read A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19 from researchers at @thesgconline: https://t.co/OJFC08f1RY.
journals.sagepub.com
SARS-CoV-2, the coronavirus that causes COVID-19, evades the human immune system by capping its RNA. This process protects the viral RNA and is essential for it...
0
4
1
Modesty comes in more than just our physical appearance. Our entire bodies, personalities, and thoughts should emanate modesty. #Haya
20
472
3K