SpruijtLab
@SpruijtLab
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Our lab uses coacervate based materials to investigate protocells, synthetic cells, and biomolecular condensates. Also on Bluesky *Operated by the lab
Radboud University, Nijmegen
Joined February 2019
Curious about the open questions in the field of liquid-liquid phase separation? Check out our latest paper in Communications Chemistry for a discussion of current insights and open questions. Read here:
nature.com
Communications Chemistry - Liquid-liquid phase separation (LLPS) underlies the formation of intracellular membraneless compartments in biology and may have played a role in the formation of...
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Still looking 👀 for a suitable candidate. Please retweet
📢 Open PhD position as part of #MSCA network of 17 students @ComeInCell Interested in exploring membrane stability/repair & #condensates ? Check out & apply: 👉 https://t.co/5C2V9dKZQU The project will include secondments at @SaricLab, @MarquesLab & @NatureComms
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Curious how biocondensates localize ions? We found that condensates selectively bind and localize both chaotropic anions and kosmotropic cations. This alters the condensate composition, interface potential and RNA duplex stability inside. By @IrisSmokers
https://t.co/AinHRInNqE
biorxiv.org
Biomolecular condensates modulate various ion-dependent cellular processes and can regulate subcellular ion distributions by selective uptake of ions. However, the molecular grammar governing...
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Selective ion binding and uptake shape the microenvironment of biomolecular condensates https://t.co/QQY08FpsZm
biorxiv.org
Biomolecular condensates modulate various ion-dependent cellular processes and can regulate subcellular ion distributions by selective uptake of ions. However, the molecular grammar governing...
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We are #hiring! For more information about our 17 #PhDposition and our #membrane and #membranecondensate projects , please check our website
🚀 Exciting News! Today marks the official launch of the ComeInCell MSCA Doctoral Network! 🎉 Join us as we embark on a journey to advance cellular research and innovation. Check the press release:
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We're thrilled to announce an open PhD position on exploring controlling condensate membrane attachment and exocytosis! Collaborate across Europe in the ComeInCell EU network. Apply now! Details: https://t.co/NA0GigKB2p &
ru.nl
Come work at Radboud University. Take a look at our scientific and non-scientific vacancies.
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Ever wondered when coacervates appeared on early Earth and what they looked like? Think no more and have a look at our new preprint! Incredibly proud of @karinakinuyo and @mihoubi_nina for their incredible work, dedication and patience! 🤩 https://t.co/1K7h169OKQ
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#ChemSystemsChem Phase-separated Droplets Can Direct the Kinetics of Chemical Reactions Including Polymerization, Self-replication and Oscillating Networks (Evan Spruijt and co-workers) #openaccess
chemistry-europe.onlinelibrary.wiley.com
Using a numerical model, we study how phase-separated compartments can influence chemical reactions. We show how the volume ratio (R) and partition coefficient (Kp) affect reaction rates in bimolec...
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Our latest preprint is now live on bioRxiv! We demonstrate how to control α-synuclein adsorption, desorption, and aggregation at charged biomolecular condensate interfaces. Check it out here:
biorxiv.org
The aggregation of amyloidogenic proteins is linked to age-related diseases. The presence of interfaces can affect their aggregation mechanism, often speeding up aggregation. α-Synuclein (αSyn) can...
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Check out a new @NaturePortfolio article collection on Liquid–liquid phase separation in cells. https://t.co/CY0YWdpnGA As part of the many great articles, you will find a Review from the @SpruijtLab published recently in Nat. Rev. Chem. https://t.co/233B8uJRfQ
nature.com
Nature Reviews Chemistry - Biomolecular condensates help organize cell components under normal conditions but can also be involved in pathological protein aggregation when condensate proteins carry...
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Want to measure the volume fraction of biocondensates or coacervates? We present easy and accurate methods, with which we found that upon destabilization, condensates can either shrink or swell, giving insight in condensate volume regulation in cells. https://t.co/gsHxwr0j9P
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The role of biomolecular condensates in protein aggregation https://t.co/pncYOtORI8 A review by Brent Visser, Wojciech Lipiński & Evan Spruijt from @SpruijtLab @Radboud_Uni
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We are thrilled to announce that our latest review on the role of biomolecular condensates in protein aggregation is now published in @NatRevChem! Many thanks to the reviewers for their valuable suggestions and feedback. Open access here:
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Our latest article in @J_A_C_S on Myelin Surfactant Assemblies as Dynamic Pathways Guiding the Growth of Electrodeposited Copper Dendrites: https://t.co/hVSCNDIaW6
#selfassembly #selforganization #lifelikematerials #systemschemistry #amphiphiles
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Coacervates can accelerate (bio)chemical reactions and direct their outcome. In our new review by @IrisSmokers we detail how their unique properties allow them to function as catalytic microcompartments at the origins of life. Have a look here: https://t.co/6QFvtva5rR
pubs.acs.org
ConspectusCoacervates are droplets formed by liquid–liquid phase separation (LLPS) and are often used as model protocells–primitive cell-like compartments that could have aided the emergence of life....
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How Droplets Can Accelerate Reactions─Coacervate Protocells as Catalytic Microcompartments
pubmed.ncbi.nlm.nih.gov
Coacervates are droplets formed by liquid-liquid phase separation (LLPS) and are often used as model protocells-primitive cell-like compartments that could have aided the emergence of life. Their...
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In our new paper, now published in @Nature, we report on the discovery and implementation of a chemical reservoir computer based on the prebiotic formose reaction. Congrats to Mathieu, Thijs, @quentin_duez , @robn_will and Wilhelm!🥳 Read the paper 👇 https://t.co/14MsWzXFDR
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The Many-Chemicals Problem of Systems Chemistry by Oliver R. Maguire @oliver_maguire
chemistry-europe.onlinelibrary.wiley.com
An E. coli cell contains ~2500 different chemicals that form a biochemical system from which a happy living bacterium emerges. A chemist combining together 2500 different chemicals from a laboratory...
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Exciting lab news! How can machine learning help us understand and predict #biomolecular #condensates? Thrilled to start my postdoc in @ProteinMagnus lab with this perspective led by Maria (@mcd_611) in @JMolBiol. Check it out! https://t.co/Uf14BuPkak
#Biophysics #MolBiol #LLPS
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An E. coli cell contains ~2500 different chemicals. A chemist combining 2500 different chemicals in a lab will result in an explosion. This is the Many-Chemicals Problem of Systems Chemistry. I explain how to overcome this key obstacle to creating more complex systems.
The Many-Chemicals Problem of Systems Chemistry by Oliver R. Maguire @oliver_maguire
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Over the weekend our publication on studying the surface charge of condensates on a single droplet level was published in @NatureComms! You can read it now here:
nature.com
Nature Communications - The surface charge and ζ-potential of biomolecular condensates is key to their interactions with membranes and proteins. Here, the authors developed a method to...
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