Andela Saric
@SaricLab
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Prof of Bio & Soft Matter Physics. Living @ISTAustria; Associated @UCL Physics & @LMCB_UCL. Simulations not animations.
Vienna, Austria
Joined September 2019
Relaxing #beachread 🏝️: filaments that grow and shrink by burning energy🔥, death💀, assembly, division ring formation 💍, and more in our new paper in @NaturePhysics
https://t.co/a6sOiIVp0B. Great collab with @nartimsoole & @seamus_holden , led by soon-doctor @vainhilla96. ⤵️
nature.com
Nature Physics - Treadmilling of cytoskeletal filaments is crucial for their functional self-organization. Now the mechanism underpinning this collective organization is shown to be the dissolution...
Did you know cell filaments love to treadmill? 🔄 They grow and shrink on opposite ends and burn energy doing it! But why? How does it drive self-organisation and bacterial division? Dive into our new publication ft. @SaricLab @nartimsoole @seamus_holden labs to find out! 🧫🔬🖥️
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Registration is open for the 2025 iteration of the wonderful @EMBOevents workshop on cell polarity and membrane dynamics #EMBOcellPolarity25 I am organizing with Ed Munro! Wonderful lineup wonderful please sign up and RT
meetings.embo.org
The ability of cells to polarize is essential for organismal development and physiology, and its impairment underlies numerous diseases. The establishment and maintenance of cell polarity requires a …
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Are you a fan of #ComputationalBiophysics?🖥️ The @SaricLab at the #ISTA is seeking a talented #PhDcandidate to investigate the fascinating interplay between #MolecularCondensates and #CellMembranes. Check our #PhDposition: https://t.co/iFMTFLeTWQ
#MSCA #ComeInCell
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New edition of Interdisciplinary challenges (IntCha25) on physics of complexity and life will take place at Heidelberg in 2025 https://t.co/X5paR0Fxv7
@embl So proud the event keeps gathering ECR for rich exchanges @Dmichiel1 ready for the 10th anniversaire? Previous Editions👇
embl.org
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Thank you @AllenInstitute for seeing the magic in #membranebiophysics 🪄✨ We’re thrilled happy to be a part of this cohort!
Using simulations, synthetic cells, and live archaeal cell communities, @SaricLab, @KGoepfrich, and Buzz Baum are challenging the assumption that the cell membrane is passive and only changes shape when acted upon. #FrontierScience
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Congratulations to Anđela Šarić @SaricLab on being named an Allen Distinguished Investigator by @PGAFamilyFdn! She will lead an international collaboration, funded with $1.5 million, to investigate how chemically active membranes influence cell shape. 🔗 https://t.co/CCpzyiwwaI
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🤩 Exciting milestone for the #MSCA Doctoral Network #ComeInCell! Today we held our kickoff meeting to drive this groundbreaking project forward. Stay tuned for insights into #SyntheticBiology, #MembraneCondensates, #NeurodegenerativeDiseases, #MembraneTrafficking & more! 🔬✨
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📢 Open PhD position as part of #MSCA network of 17 students @ComeInCell Interested in exploring membrane stability/repair & #condensates ? Check out & apply: 👉 https://t.co/5C2V9dKZQU The project will include secondments at @SaricLab, @MarquesLab & @NatureComms
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We're hiring for a MSCA PhD position! @ComeInCell We're curious about how biological condensates can be actively targeted to membrane surfaces with the thoroughly mastered self-assembling protein machinery. Check out the project at
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The ITN ComeInCell 🧫 https://t.co/BXdX44l5Px is UP sand running! Interested in synthesizing life-like systems from the bottom up? 🔊Apply now to the 2 PhD positions that we offer @ciqus within an outstanding network!! RT is highly appreciated! ⏰👉 https://t.co/eN8I0na1Jv
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We're super excited to launch ComeInCell- a doctoral network aimed to develop advanced cellular mimics that integrate functional membrane structures and biomolecular condensates. With a team of 14 PIs and 13 associated partners, this will be an exciting journey!
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Archeal monolayer membrane properties. Interesting work from @SaricLab. Are there implications for origin of life? https://t.co/8Aez4hyVTb
biorxiv.org
Across the tree of life, distinct designs of cellular membranes have evolved that are both stable and flexible. In bacteria and eukaryotes this trade-off is accomplished by single-headed lipids that...
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Taken together, we find membrane tradeoff design principles evolved in extremophiles - stability vs reshapeability - that can be valuable for (bio)technological applications. (7/7) 🙏 @sciFelixFrey , @xiuyun_jiang , @BaumBuzz @SaricLab preprint →
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Did you know there are more than bilayer #membranes in nature? Meet the #archaeal monolayer and its surprising mechanical properties! New #preprint! (1/7)
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A great 🇬🇧-🇦🇹team of @BillieMeadowcr1 (currently cycling 🚴♀️ across 🇺🇸) @IvnPla @v_sorichetti and Eryk teamed up with with @NargessKGharibi and @YanlanMao to simulate collagen-iv remodelling under strain and enzymatic activity. @ISTAustria
@LMCB_UCL @UCL_IPLS More ⬇️
Collagen-IV networks rule the #mechanics of our epithelia, but we know little about how they reshape. Our new preprint (with the 1st coarse-grained MD models of #collagen-IV!) shows how consuming energy during remodelling might make the difference: 📑 https://t.co/yTRbg87fRn 🧵
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Apply! 📝
Take your career to the next level: #FacultyCall @ISTAustria is open! We're seeking exceptional group leaders in #chemistry, #ComputerScience, #DataScience, #EarthScience, #LifeSciences, #mathematics, and #SoftMatterPhysics to join our institute. Apply 🔗 https://t.co/6HZ4KAtAkN
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He’s currently travelling around South Korea 🇰🇷🍜 before continuing his research path. ⛰️Huge thanks to Karsten Kruse and Philip Pearce @pearce_maths for being on his committee @UCL_IPLS , and looking forward to all the great things he’ll do in the future.
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New PhD in the family!: Chris Vanhille Campos @vainhilla96 🍸🥂🧉🧁. Chris was our stellar ☄️💫 student with many passions — from bacterial division, to vesicle reshaping, condensates, self-assembly, guitar, icey Danube 🧊, braving bears, to making softies @ISTAustria happy 🍧
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The actin #cortex is attached to the #membrane via linking proteins. When these linkers get trapped in the cortex meshes, actin jams🚧, #contractility stops🛑 and cells polarise☄️Exciting collaboration (+ real fun!) with @diz_lab @TesoroRuben @SaricLab 📑 https://t.co/MsQac80tYM
New Preprint! How can cells polarize in the absence of a stimulus? We suggest a surprising biophysical mechanism, protein caging! We reveal how the complex mechanical interactions at the cell surface lead to symmetry breaking. https://t.co/BOwbtxlago
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New Preprint! How can cells polarize in the absence of a stimulus? We suggest a surprising biophysical mechanism, protein caging! We reveal how the complex mechanical interactions at the cell surface lead to symmetry breaking. https://t.co/BOwbtxlago
biorxiv.org
To migrate, divide, and change shape, cells must regulate the mechanics of their periphery. The cell surface is a complex structure that consists of a thin, contractile cortical actin network...
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