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6) The deep dorsal horn plays an important role in sensory-evoked inhibition of motor networks. Without this inhibition, the timing and magnitude of the sensory cues that guide motor output go awry, reducing the ability for smooth motor performance.

5) Reducing this inhibition resulted in altered limb kinematics (hyperflexion at swing-to-stance), altered gait (preference for ‘fast’ walking), and reduced transitions between sub-movements during spontaneous behavior.

4) By inhibiting an array of premotor and motor circuits, these cells play an important role in gating cutaneous-evoked muscle activity.

3) We identified a population of PV+ glycinergic inhibitory interneurons that receive cutaneous, proprioceptive, and cortical inputs that shape their activity patterns.

2) We characterized excitatory and inhibitory neurons within the deep dorsal horn and show inhibitory neurons are ‘more excitable’ than their excitatory counterparts, and are more likely to be recruited during locomotion.

1) We corroborate previous work highlighting the medial deep dorsal horn as a region of cutaneous and proprioceptive convergence and show that individual neurons in this region receive both types of input.

Firstly, a huge thank you to @PrescottLab and Turgay Akay's lab for their invaluable contributions!.

Check out new work from @VAbraira lab examining how inhibitory neurons in the deep dorsal horn integrate sensory inputs to inform motor outputs. 🧵.

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RT @PrescottLab: Excited to be part of this incredible work by @SpinalCordMark and @VAbraira, out now in @NeuroCellPress! 🎉. .

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