Prescott Lab
@PrescottLab
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Prescott Lab at SickKids and @UofT. Investigating the biophysical basis of #computation & the computational basis of #pain. š§ ā” Tweets by Steve & lab.
Toronto, ON
Joined September 2022
Our latest work uses @RAMalgoTheRobot to investigate the role of different somatosensory afferents in pain sensitivity š¢.
Quantifying the contribution of somatosensory afferent types and changes therein to pain sensitivity using transcutaneous . #biorxiv_neursci.
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Our latest work led by @laurmedlock on touch encoding in rodents is out now and featured by @SfNtweets! . š Read it here:
www.jneurosci.org
Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in the rodent glabrous skin has received...
Out now in @SfNJournals! š Our latest work on touch and vibration sensing in rodent mechanoreceptors. A beautiful experimental and modelling collaboration thanks to Dhekra Al-Basha, @Chris_Dedek, @AHalawa99 and the whole @PrescottLab team.
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Interested in Na+ channels and pain? . Come talk to Stephanie at #SfN2024 about our recent work showing that different Nav channel combinations can yield similar excitability in nociceptors! . š” Monday 8-12pm at 165.18
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RT @laurmedlock: Iām at #SfN2024 presenting my latest work on spinal receptive fields and pain. We show that spatially and temporally disoā¦.
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RT @GeoffroyLaumet: First in-person #RitaAllenFoundation meeting since the pandemic! It was fantastic to learn about so much great scienceā¦.
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RT @camp_course: We thank Dr Steven Prescott @PrescottLab for being with us at IISER Pune and sharing his expertise .
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Inconvenient but trueā¦ different Nav channel combinations can yield similar excitability in nociceptors ā”ļø. Thanks for sharing @KhannaLabUF!.
HOWZAT!!!."Degeneracy makes it impossible to claim w/o reservation that one NaV subtype is uniquely responsible for pathological pain" š¤Æ.@eLife: Similar excitability through different NaV channels & implications for analgesic efficacy of selective drugs
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RT @laurmedlock: Iām presenting on spatiotemporal processing and spinal receptive fields tomorrow at #CAN2024 š. Stop by P3-D-439 for a lilā¦.
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The Prescott Lab is at #CAN2024 in beautiful Vancouver šļø. Stop by @Chris_Dedekās poster today to meet @RAMalgoTheRobot and see our latest work in robotics, machine learning, and pain.
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If you are interested in @RAMalgoTheRobot for your lab, please get in contact! š¤.
www.thetransmitter.org
Two new devices take experimenter variation out of the equation, the lead investigators say.
This just in: There are better ways to perform nociceptive behaviour tests! Read the latest @_TheTransmitter article highlighting the importance of reducing variability, including our work in the @PrescottLab!.
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Congratulations to the team! Very exciting work.
1. Excited to share our improvement of pain testing in rodents. No more back-breaking inconsistent poking of mouse paws. We present the ARM (Automated Reproducible Mechano-stimulator). 1/7 .
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Excited to be part of this incredible work by @SpinalCordMark and @VAbraira, out now in @NeuroCellPress! š. In this work, @laurmedlock uses a network model to show how PV+ inhibitory neurons in the deep dorsal horn gate cutaneous-evoked muscle activity.
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Check out this great summary of our latest work in @NeuroCellPress on high-frequency #SpinalCordStimulation. ā”ļø Thanks @MCapogrosso and @scott_lempka!.
Together with an Evan Roger and @scott_lempka we published today a preview to the beautiful work from @PrescottLab detailing the effects of High-Frequency spinal cord stimulation on sensory axons! We need more of these works in the field! #neurotech
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RT @laurmedlock: Our latest #preprint on touch encoding in rodent mechanoreceptors is out now! š. š Many thanks toā¦.
www.biorxiv.org
Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in rodent glabrous skin has received scant...
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RT @AnnemarieDedek: Check it out!!! @RAMalgoTheRobot is going to change the game for measuring #pain in rodent models!.Huge congratulationsā¦.
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RT @RAMalgoTheRobot: Want to learn more about me? š¤ My instructions and impressive capabilities are now published in @CellRepMethods. Prouā¦.
www.cell.com
Preclinical pain testing traditionally utilizes techniquesāsuch as stimulating by hand and measuring responses by eyeāthat limit reproducibility. Dedek etĀ al. describe a device for consistent...
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Plus, follow @RAMalgoTheRobot for all the latest updates!. . #ReproducibilityInScience #MouseBehavior #Painresearch.
Want to learn more about me? š¤ My instructions and impressive capabilities are now published in @CellRepMethods. Proudly created by @Chris_Dedek and the @PrescottLab. #PainResearchForum #Pain #RodentBehavior .
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20 years ago, Chesler et al. showed that the greatest source of variability in evoked pain responses was the experimenter. This is at the core of poor reproducibility. @chris_dedek built @RAMalgoTheRobot to fix that. š¤ . Out now in @CellReportsMethods!.
www.cell.com
Preclinical pain testing traditionally utilizes techniquesāsuch as stimulating by hand and measuring responses by eyeāthat limit reproducibility. Dedek etĀ al. describe a device for consistent...
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