Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 https://t.co/E2fZXw2Pom

Evaluation of Alphafold modeling for elucidation of nanobody-peptide epitope interactions

https://t.co/V3gCexpZT6

Here to put the “boo” in boo-orthogonal click chemistry—and maybe pull a few tricks (or treats)! 🎃🧪 Happy #Halloween from the lab! #SpookyScience #LabHalloween

Degrader Tac-opedia 🔘PROTAC: E3 ligase-targeted proteolysis 🔘DUBTAC: Deubiquitinase stabilization 🔘LYTAC: Lysosome-targeted degradation 🔘Trivalent PROTAC: Multivalent E3 ligase 🔘AUTAC: Autophagy-targeted degradation 🔘RIBOTAC: RNA-targeted degradation 🔘RNA-PROTAC:

Nobel Prize is NOT about h-index or citations. It is about the emergence of big new fields. So many posts discuss Nobel awardees. And so many misunderstand the Nobel Prize. 📍 A bit of clarification from my side: 1⃣ Nobel Prize is NOT about how useful your work is. It’s about

Congratulations to the 2024 #NobelPrize in Chemistry winners, Drs. David Baker, Demis Hassabis and John M. Jumper! Dr. Baker’s #NIH-supported work at @UWMedicine building new kinds of proteins is an incredible example of the value of taxpayer investment in biomedical research.

So she was first author on his key paper - in fact she's on most of his key papers, yet she didn't get the Nobel Prize, in spite of the fact they could have given 3 awards, not just 2. Explain to me how STEM is not institutionally sexist.

Excited to share new work from our lab led by Uyen Pham – “Location-biased β-arrestin conformations direct GPCR signaling.” We demonstrate that b-arrestins display distinct conformations in different subcellular locations in regulating ERK MAP kinases.

Cryo-EM structure of GPR179, a GPCR crucial for visual signalin, reveals how its dimer architecture fits curved membranes . @KLabGPCR https://t.co/EUUUOBPWeh

👩‍🔬 👨‍🔬 Join us for the 4th Transatlantic ECI GPCR Symposium this Thursday and Friday! Come for science done by ECIs, ask about current & future trends in lunch sessions, hear career panel discussion, and network! Last hours for registration: https://t.co/HHCAx1avGh

Now published in @PLOSBiology: How GRK kinases control #GPCR signaling in the #Hedgehog transduction cascade in primary #cilia. https://t.co/BRi7tOMZ4A

My lab has multiple openings for those interested in doing some very cool science in beautiful Colorado! Research assistants (tech/lab manager level): https://t.co/cf30hlFdzT Postdoctoral fellows: https://t.co/Tg9HlOGZAS DM or email me if interested and 🙏 share broadly 🪃

New from Pharmechanics, a YouTube-based workshop on analyzing kinetic signaling data for GPCRs. Watch and learn how to do curve fitting on GPCR time course signaling data.

Had an amazing last week in NH at #GRC phosphorylation and G-protein mediated signaling networks. Great science, engaging talks, and new research ideas. A huge thank you to the #NIH Fellows Award for Research Excellence and the Cheloha Group at #NIDDK for making this possible!!!

Wow--mind blown! "Computational design of soluble and functional membrane protein analogues" @BShoichet @RothLabUNC https://t.co/o6xRH3LixM

Not my usual outside the🪟view!!! Enjoying amazing talks and stunning views at #GRC phosphorylation and G-protein signaling networks 🧪🏞️

Authors @rche54, @shivdoesscience and colleagues demonstrate that tethering ligands to GPCR receptors via conjugation with binding nanobodies enables pathway-specific signaling https://t.co/Wok0OKbyWr

Super excited to see this out!!! Published in @NatureComms (and open access!)🔥 Highly Pathway Selective #GPCR Signaling via Nanobody Tethering🦙💊 A 🧵